Novel biocompatible phosphorylcholine-based self-assembled nanoparticles for drug delivery

Self-assembling systems based on diquaternized derivatives of 1,4-diazabicyclo[2.2.2]octane

“…This method is widely used not only for the detection of the micelle formation and cmc values, but also for the characterization of the solubilization power of aggregates based on the absorbance of the dyes at ca. 500 nm [49][50][51][52].…”

Multifunctional Nanoparticulate Polyelectrolyte Complexes

“…These vesicles then undergo a complex series of fusion events directing the internalized cargo to an appropriate intracellular compartment (uptake of fluids, macromolecules, particles and other ligands that sort to cellular processing pathways). Intracellular uptake studies have largely focused on liposome (75)(76)(77) and polymer delivery systems (20,78,79). Kinetically, three specific modes of endocytosis have been implicated in the context of delivery systems: fluid-phase, adsorptive, and receptor-mediated endocytosis (80).…”

Polymerisation of 2-acrylamido-2-methylpropane sulfonic acid sodium salt (NaAMPS) and acryloyl phosphatidylcholine (APC) via aqueous Cu(0)-mediated radical polymerisation

“…[11][12][13][14][15][16] Likewise, both ATRP and RAFT have been exploited for the controlled polymerisation of betaine monomers. [17][18][19][20][21][22] The resulting polymers have found use in protein/peptide conjugation 23 and surface modification technologies 24,25 as well as in the fabrication of polymer nanoparticles [26][27][28][29][30] decorated in, and possessing the desirable properties of polyzwitterionic constituents.…”