Novel binuclear μ-oxo diruthenium complexes combined with ibuprofen and ketoprofen: Interaction with relevant target biomolecules and anti-allergic potential

Seuanes, Gabriela Campos; Moreira, Mariete Barbosa; Petta, Tânia; Lama, Maria Perpétua Freire de Moraes Del; Moraes, Luiz Alberto Beraldo de; Oliveira, Anderson Rodrigo Moraes de; Naal, Rose Mary Zumstein Georgetto; Nikolaou, Sofia

doi:10.1016/j.jinorgbio.2015.08.004

Cited by 13 publications

(12 citation statements)

References 44 publications

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“…; they exert their therapeutic effects by inhibiting the release of prostaglandin and thromboxane hormone produced in human body by enzymatic transformation. [1][2][3] However, beyond certain limit, the use of NSAIDs is associated with various side effects such as kidney failure and gastrointestinal problems. [4] Synthesis, physicochemical and structural investigations of metal complexes with active pharmaceuticals NSAIDs in which the drug molecules play a role of ligand when deprotonated (i.e., as anion) have been regarded as a research area of increasing interest for inorganic, pharmaceutical and medicinal chemistry.…”

Section: Introductionmentioning

confidence: 99%

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New copper(ii) complexes of the anti-inflammatory drug mefenamic acid: a concerted study including synthesis, physicochemical characterization and their biological evaluation

et al. 2016

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Section: Introductionmentioning

confidence: 99%

“…1 Various possible coordination modes of carboxylate group in NSAIDs towards metal center. Out of these most commonly observed are monodentate (1), bidentate chelating (2) and bidentate bridging (all others).…”

Section: Introductionmentioning

confidence: 99%

New copper(ii) complexes of the anti-inflammatory drug mefenamic acid: a concerted study including synthesis, physicochemical characterization and their biological evaluation

et al. 2016

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“…The traditional form of K has no anti-allergic properties. Saunas et al synthesized a novel binuclear μ-oxo diruthenium complex combined with K: [Ru 2 O(K) 2 (pie) 6 ](PF 6 ) 2 where py = pyridine [15], and then used rat basophilic leukemia (RBL-2H3) cells to study mast cell degranulation. According to the results of the study, allergens stimulated degranulation of mast cells and the new drug inhibited mast cell activation and degranulation.…”

Section: Anti-allergic Potentialmentioning

confidence: 99%

New uses of ketoprofen – a review of studies from 2015 to 2021

Kuczyńska

Nieradko-Iwanicka

2022

Current Issues in Pharmacy and Medical Sciences

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Ketoprofen (K) belongs to the family of nonsteroidal anti-inflammatory drugs (NSAIDs) and demonstrates analgesic, anti-inflammatory and antipyretic properties. K is one of the most commonly used NSAIDs because of the speed and effectiveness of its activity. K is currently used for the treatment of pain and treatment of symptoms in rheumatic diseases, however, many researchers are looking for new uses of K. The aim of the review was to present the possible applications of K as indicated in current literature. We searched research literature and compiled all the reports (2015 onwards) we could find about new possible employments of K in health practices. Many studies have been aimed at obtaining new uses of K. This article describes the use of ketoprofen lysine salt for treating injured gastric mucosa, the anti-allergic potential of K, the employment of K in treating nonalcoholic fatty liver disease, human lymphedema and seizures, as well as the antidepressant and anxiolytic effects of K, prospects for the use of K in oncology and transplantology. The findings of the review confirm that K, its derivatives and complexes have many newly discovered effects. It is likely that in the future, K will have more indications than it has today.

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“…A conhecida ativação antígeno-mastocítica desencadeia uma cascata de sinalização responsável pelos sintomas de inflamação alérgica, segundo Seuanes et al (2015). A liberação de muitos mediadores químicos, como mediadores lipídicos, prostaglandinas e leucotrienos, citocinas, IL-4, TNF-α e conteúdo de grânulos citoplasmáticos, histamina, β-hexosaminidase e serotonina estão relacionados a esse processo (GALI; TSAI; PILIPONSKY, 2008).…”

Section: Liberação De β-Hexosaminidade E Citotoxicidade Em Mastócitosunclassified

Nanopartículas lipídicas sólidas encapsulando curcuminoides (NLS-CT): estudos in vitro e in vivo

Zamarioli¹

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DEDICATÓRIA À Deus, que com seus trabalhadores incansáveis, conspirou para a realização de uma pesquisa como esta, partindo de uma aparente "tábula rasa". À todos que poderão ser beneficiados pelo produto que está sendo desenvolvido, podendo ser um alívio nas vidas tão sofridas como as dos pacientes oncológicos. Aos meus pais, que com muito empenho, amor e dedicação permitiram meu retorno ao lar e a minha permanência em tempos difíceis. Meu eterno amor e respeito. Sem vocês nada disto teria sido possível!!!!! Ao meu irmão querido e minha sobrinha tão minha. Família é a alma da gente se expressando através do outro. Muitos dias não pude compartilhar da presença de vocês. Só tenho que pedir desculpas por isso! À enfermagem que, com muita garra, tem tentado melhorar a qualidade de vida dos pacientes contando, por vezes, com um arsenal pequeno numa guerra tão grande. Ao grupo de pesquisa Enfermagem e Comunicação que tem se empenhado em pesquisar temas alternativos, com ousadia e dedicação.

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Novel binuclear μ-oxo diruthenium complexes combined with ibuprofen and ketoprofen: Interaction with relevant target biomolecules and anti-allergic potential

Cited by 13 publications

References 44 publications

New copper(ii) complexes of the anti-inflammatory drug mefenamic acid: a concerted study including synthesis, physicochemical characterization and their biological evaluation

New copper(ii) complexes of the anti-inflammatory drug mefenamic acid: a concerted study including synthesis, physicochemical characterization and their biological evaluation

New uses of ketoprofen – a review of studies from 2015 to 2021

Nanopartículas lipídicas sólidas encapsulando curcuminoides (NLS-CT): estudos in vitro e in vivo

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