Novel berberine triazoles: Synthesis, antimicrobial evaluation and competitive interactions with metal ions to Human Serum Albumin

Antioxidant Effect of Berberine and its Phenolic Derivatives Against Human Fibrosarcoma Cells

“…The antioxidant capacity of berberine has demonstrated both direct (Jang et al, 2009;Bashir and Gilani, 2011) and indirect activities (Hwang et al, 2002;Tan et al, 2007). Recently, berberine has been structurally modified to yield new derivatives which are able to improve their biological functions: antibacterial (Zuo et al, 2012;Zhang et al, 2013), antifungal (Liu et al, 2014), antiprotozoal (Bahar et al, 2011), and anticancer activities (Zhang et al, 2012;Lo et al, 2013).…”

Design, synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents

“…Ethyl berberine A3 was an effective anti-tubercular agent (MIC = 0.125 mg/mL) and exhibited more potent effect against rifampicin (RIF)-and isoniazid (INH)-resistant mycobacterium tuberculosis strains than both RIF and INH, suggesting a new mechanism of action [5]. In recent years, the introduction of heterocycles into berberine as antimicrobial agents has also attracted extensive interest [6][7][8]. Berberine-triazole A4 showed potent antibacterial activity especially against Escherichia coli DH52, Shigella dysenteriae, Pseudomonas aeruginosa and Proteus vulgaris with low MIC values ranging from 2 to 64 µg/mL, which were comparable to or even better than the reference drugs berberine, chloromycin, norfloxacin and fluconazole [6,7].…”

In vitro and in vivo antifungal activity, liver profile test, and mutagenic activity of five plants used in traditional Mexican medicine

“…Recent studies have found that berberine azoles exhibited good antimicrobial activity against Candida mycoderma (Zhang et al, 2013c), andberberine triazoles has good activity against C. mycoderma and C. albicans. This activity was comparable or better than the reference drugs berberine, norfloxacin and fluconazole (Zhang et al, 2013b). Thus, the antifungal activity observed in B. hartwegii could be due to the presence of berberine.…”