Novel benzoylthiourea derivatives had differential anti-inflammatory photodynamic therapy potentials on in vitro stimulated mammalian macrophages

Emen, Fatih Mehmet; Kutlu, Emine; Karaçolak, Ali İhsan; Ali, Muhammad Asım; Demirdöğen, Ruken Esra; Yeşilkaynak, Tuncay; Erat, Selma; Ayaz, Furkan

doi:10.1016/j.pdpdt.2021.102685

Cited by 8 publications

(5 citation statements)

References 41 publications

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“…After these procedures, TMB (100 µL—BD OptEIA) was added to each of the wells, and sulfuric acid (50 µL 1 M) was added to stop the reaction. Their absorbance was measured at 450 nm [ 29 , 30 ]. Calculations were made for each sample (TNF-α, IL-6, IL12p40, and GM-CSF) using cytokine concentrations with known standards.…”

Section: Methodsmentioning

confidence: 99%

Immunostimulatory activity of fluoxetine in macrophages via regulation of the PI3K and P38 signaling pathways

2022

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Fluoxetine is an antidepressant drug that is heavily preferred in the cure of depression, which is from the selective serotonin reuptake inhibitor (SSRI) group. There are many reports on the effect of fluoxetine on the immune system, and its effect on the macrophage cells has never been looked at before. We aimed to demonstrate the cytokine production potential of fluoxetine antidepressant, which is widely used in the clinic, in the J774.2 cell line and its effect on PI3K and P38 pathways. The use of fluoxetine alone in J774.2 macrophage cells showed immunostimulatory properties by inducing the production of tumor necrosis factor-α (TNF-α), interleukin (IL) IL-6, IL-12p40, and granulocyte–macrophage colony-stimulating factor (GM-CSF) cytokines. It showed anti-inflammatory properties by completely stopping the production of cytokines (IL-6, IL12p40, TNF-α, and GM-CSF) at all concentrations where LPS and fluoxetine were used together. While PI3K and P38 pathways were not effective in the immunostimulatory effect in the presence of the drug agent, we found that the PI3K and P38 pathways were influenced during their anti-inflammatory activity.

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Section: Methodsmentioning

confidence: 99%

Immunostimulatory activity of fluoxetine in macrophages via regulation of the PI3K and P38 signaling pathways

2022

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“…61). 67 Novel acyl thiourea derivative (44) was synthesized and characterized by Khalid et al, single Crystal XRD analysis showed that the compound crystallized in a monoclinic crystal system with a P2 1 /n space group. Two planar aromatic rings of the compound were present at a dihedral angle of 33.32(6)°to one another.…”

Section: Molecular and Crystal Structurementioning

confidence: 99%

“…61). 67 The anti-inammatory activity of seven novel 1,4-naphthoquinone acyl thiourea hybrids (135a-g) was investigated by evaluation of the production of 4 different cytokines (TNFa, IL6, IL12p40, GM-CSF) and was performed in presence and absence of LPS (Fig. 62).…”

Section: Biological Aspectsmentioning

confidence: 99%

Exploring the latest trends in chemistry, structure, coordination, and diverse applications of 1-acyl-3-substituted thioureas: a comprehensive review

Ullah,

Saeed,

Azeem

et al. 2024

RSC Adv.

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“…These compounds are interesting in pharmacy, medicine, and agriculture as potential biologically active substances. Acylated thioureas are known to exhibit anticancer [2], anti‐inflammatory [3], antibacterial [4], antioxidant [5], antifungal [6], larvicidal [7], and herbicidal [8] activity. Polymerizable acyl thioureas have been proposed to be used as hardeners to create compositions for dental materials [9].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral characteristics and molecular structure of 2H‐1,3,5‐oxadiazine‐2,4(3H)‐diimine derivatives

Pokotylo

Zadorozhnii

Kiselev

et al. 2023

Journal of Heterocyclic Chem

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In this work, we report the synthesis of 2H‐1,3,5‐oxadiazine‐2,4(3H)‐diimine derivatives based on acylated thioureas. The method for the preparation of 1,3,5‐oxadiazine derivatives is based on the reaction of dehydrosulfurization of the starting acylated thioureas under the action of dicyclohexylcarbodiimide (DCC) followed by the [4 + 2] cycloaddition reaction of another DCC molecule to the resulting intermediate carbodiimide. The structure of the obtained derivatives of 1,3,5‐oxadiazine was confirmed by 1H, 13C NMR, IR spectroscopy, mass spectrometry, and x‐ray diffraction analysis.

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Novel benzoylthiourea derivatives had differential anti-inflammatory photodynamic therapy potentials on in vitro stimulated mammalian macrophages

Cited by 8 publications

References 41 publications

Immunostimulatory activity of fluoxetine in macrophages via regulation of the PI3K and P38 signaling pathways

Immunostimulatory activity of fluoxetine in macrophages via regulation of the PI3K and P38 signaling pathways

Exploring the latest trends in chemistry, structure, coordination, and diverse applications of 1-acyl-3-substituted thioureas: a comprehensive review

Synthesis, spectral characteristics and molecular structure of 2H‐1,3,5‐oxadiazine‐2,4(3H)‐diimine derivatives

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