Novel benzoxazole-based thiosemicarbazide derivatives as new inhibitors of urease and β-Glucuronidase: Synthesis, in vivo anti-nematodal activity and ADMET prediction along with in silico study

Synthetic transformation of 6-Fluoroimidazo[1,2-a]Pyridine-3-carbaldehyde into 6-Fluoroimidazo[1,2-a]Pyridine-Oxazole Derivatives: In vitro urease inhibition and in silico study

“…However, the analogues 4c bearing phenyl group at para -position (IC 50 = 81.49 ± 7.18 μM) and 4f bearing toluene moiety on para -position (IC 50 = 71.69 ± 6.13 μM) were found to be three-fold least potent of urease inhibitor as compared to the standard drug thiourea (IC 50 = 21.37 ± 1.76 μM). Because the phenyl, toluene, -N(CH 3 ) 2 have bulky nature present at para -position of the aryl part of the oxazole ( Gattu et al, 2023 , Khan et al, 2023 , Vanjare et al, 2023 ) resulted to reduced inhibitory potentials against urease inhibitor. The analogue 4c bearing para -phenyl moiety at aryl part and analogue 4f having para -toluene moiety at the same para -position were showing least potent competitor against urease inhibitor.…”