Novel Aspects of the Renal Renin-Angiotensin System: Angiotensin-(1-7),ACE2 and Blood Pressure Regulation

Chappell, Mark C.; Modrall, J. Gregory; Diz, Debra I.; Ferrario, Carlos M.

doi:10.1159/000078713

Cited by 78 publications

(113 citation statements)

References 56 publications

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“…The combination of physiologic and pharmacological approaches with molecular biology techniques has led to the identification of novel RAS components: Ang III, Ang IV and Ang-(1-7) (7,8,9); the Ang IV binding site insulin-regulated aminopeptidase (10); angiotensin-converting enzyme 2 (ACE2), an homologue of the "classic" angiotensin-converting enzyme (ACE) (11,12,13); and the Ang-(1-7) G protein-coupled receptor Mas (14). Among the novel RAS metabolites, Ang-(1-7) is particularly interesting.…”

Section: Hronic Renal Failure (Crf) In Childhood Frequently Resultsmentioning

confidence: 99%

“…This heptapeptide is functionally linked to mechanisms that intrinsically regulate the function of the RAS (7,8,9,15). Ang-(1-7) is formed from Ang II by prolylendopeptidase, prolyl-carboxipeptidase or ACE2 (11,12,13) or directly from Ang I through hydrolysis by prolylendopeptidase and endopeptidase24.11 and metabolized by ACE to Ang-(1-5) (7,9). ACEi elevate Ang-(1-7) concentrations (16) by both increasing Ang I, the substrate for Ang-(1-7), as well as by preventing Ang-(1-7) degradation.…”

Section: Hronic Renal Failure (Crf) In Childhood Frequently Resultsmentioning

confidence: 99%

“…ACEi elevate Ang-(1-7) concentrations (16) by both increasing Ang I, the substrate for Ang-(1-7), as well as by preventing Ang-(1-7) degradation. Ang-(1-7) opposes the vascular and proliferative effects of Ang II and exerts complex renal actions (7,8,9,15). Recent studies suggest that, at least in part, the beneficial effects of ACEi in heart and kidney diseases may be attributed to Ang-(1-7) (17).…”

Section: Hronic Renal Failure (Crf) In Childhood Frequently Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Circulating Renin Angiotensin System in Childhood Chronic Renal Failure: Marked Increase of Angiotensin-(1–7) in End-Stage Renal Disease

et al. 2006

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Section: Hronic Renal Failure (Crf) In Childhood Frequently Resultsmentioning

confidence: 99%

Section: Hronic Renal Failure (Crf) In Childhood Frequently Resultsmentioning

confidence: 99%

Section: Hronic Renal Failure (Crf) In Childhood Frequently Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Circulating Renin Angiotensin System in Childhood Chronic Renal Failure: Marked Increase of Angiotensin-(1–7) in End-Stage Renal Disease

et al. 2006

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“…Inhibition of ACE decreases Ang II production and increases Ang-(1-7) because of the following: (1) increased Ang-(1-7) formation from elevated levels of Ang I; and (2) inhibition of Ang-(1-7) metabolism by ACE. 19,42,[52][53][54][55][56] On the other hand, blockade of AT 1 receptors with its attendant elevation in both Ang I and Ang II stimulates ACE2 activity while facilitating an increase in Ang-(1-7) formation through the other Ang-(1-7)-forming enzymes. 20,48,49 …”

Section: Exploring the Significance Of The Ace Ace2 And Ang-(1-7) Axismentioning

confidence: 99%

Angiotensin-Converting Enzyme 2 and Angiotensin-(1-7)

2006

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Abstract-This lecture summarizes the chronology and rationale that led to the discovery of angiotensin-(1-7) as a hormone that, in its own right, opposes the vasoconstrictor and proliferative actions of angiotensin II. The work discussed here additionally analyzes the newest findings on angiotensin-converting enzyme 2, the angiotensin-converting enzyme homologue that efficiently hydrolyzes angiotensin II into angiotensin-(1-7). Both components of this system may significantly influence our future perspective of the role of the renin-angiotensin system, not just in terms of its role in the regulation of cardiovascular and renal function but, moreover, as regulators of a vast array of disease processes in which inflammation and immune mechanisms play a role.

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“…In isolated, perfused rat kidneys and anesthetized animals [172,173], ANG-(1-7) has been shown to increase sodium and water excretion and the glomerular filtration rate (GFR) without affecting renovascular resistance. Hence, it is also possible that ANG-(1-7) induces diuresis and natriuresis by inhibiting renal tubular Na+/K+-ATPase [174,175]. However, ANG-(1-7) also induced antidiuresis in water-loaded rodents (258) and increased renal tubular sodium reabsorption in rats [176].…”

Section: Actions Of Ang-(1-7) In the Kidneymentioning

confidence: 99%

ANG II, ANG-(1-7), ALDO and AVP biphasic effects on Na+/H+ transport: the role of cellular calcium

Mello-Aires¹,

Dellova²,

Castelo‐Branco³

et al. 2017

Nephrol Renal Dis

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This article reviews the main body of knowledge regarding NHE1 and NHE3 exchangers and their interaction with Angiotensin II, Angiotensin-(1-7), Aldosterone and Arginine Vasopressin, particularly their renal actions. This work addresses the biphasic effects of different hormonal doses on NHE1 or NHE3 in proximal tubule in Wistar, SHR (hypertensives) and their control WKY (normotensives) rats or MDCK cells (which share similarities with the collecting duct). The hormones were applied alone, with their inhibitors or plus agents that change the [Ca 2+ ]i. The data are compatible with hormonal stimulation of these exchangers by increases of [Ca 2+ ]i in lower range, and inhibition at high [Ca 2+ ]i. In MDCK cells and Wistar rats, low doses of ANG II, ALDO or AVP stimulated the exchangers, while high doses inhibited them. ANG-(1-7), in Wistar or WKY rats has inverse, dose-dependent effects. In SHR rats, the biphasic effects of ANG-(1-7) were similar to the effects of ANG II, ALDO or AVP in Wistar rats. The interactions between these effects may represent a mechanism that regulates extracellular volume. In hypertensives animals, a high plasma level of ANG-(1-7) inhibited NHE3 in the proximal tubule, which mitigated hypertension. Figure 6 shows a schematic model to describe these biphasic hormonal effects.

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Novel Aspects of the Renal Renin-Angiotensin System: Angiotensin-(1-7),ACE2 and Blood Pressure Regulation

Cited by 78 publications

References 56 publications

Circulating Renin Angiotensin System in Childhood Chronic Renal Failure: Marked Increase of Angiotensin-(1–7) in End-Stage Renal Disease

Circulating Renin Angiotensin System in Childhood Chronic Renal Failure: Marked Increase of Angiotensin-(1–7) in End-Stage Renal Disease

Angiotensin-Converting Enzyme 2 and Angiotensin-(1-7)

ANG II, ANG-(1-7), ALDO and AVP biphasic effects on Na+/H+ transport: the role of cellular calcium

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