Novel aspects of pathogenesis and regeneration mechanisms in COPD

Bagdonas, Edvardas; Raudoniūtė, Jovilė; Bružauskaitė, Ieva; Aldonytė, Rūta

doi:10.2147/copd.s82518

Cited by 112 publications

(95 citation statements)

References 214 publications

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“…It has been proven that occupational exposure to VGDF can initiate a local inflammatory process in the airways 11) . In our study, the assessment of induced sputum revealed that IL-1β, IL-6, TNF-α, and MMP-9 are involved in a local inflammatory process in the airways of COPD patients although their serum concentrations were not increased.…”

Section: Discussionmentioning

confidence: 99%

Comparison of biomarkers in serum and induced sputum of patients with occupational asthma and chronic obstructive pulmonary disease

Kleniewska

Walusiak‐Skorupa

Piotrowski

et al. 2016

Journal of Occupational Health

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Objectives: Occupational asthma and chronic obstructive pulmonary disease (COPD) are associated with the airway inflammatory process. The aim of this study was to compare the sputum and serum markers of inflammation in patients with occupational asthma and COPD. Methods: The study group included 20 patients with stable COPD, 24 patients with asthma, and 22 healthy subjects. Interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, matrix metalloproteinase (MMP)-9 levels in serum and induced sputum as well as fibrinogen and CRP in serum were determined in all the subjects. Results: Higher concentrations of IL-1β, IL-6, TNF-α, and MMP-9 in induced sputum and an increased concentration of acute-phase proteins in serum were observed in COPD patients compared with healthy subjects. Higher concentrations of IL-1β and MMP-9 in induced sputum and a higher concentration of C-reactive protein (CRP) were detected in COPD patients than in asthmatic subjects. Never smokers with COPD had significantly higher levels of IL-1β and MMP-9 in induced sputum than never smoker controls. There was no significant difference between the serum and sputum levels of cytokines and MMP-9 of never smokers and smokers with COPD. Conclusions: Higher concentrations of IL-1β and MMP-9 in induced sputum and a higher concentration of CRP in serum allow distinguishing between biomarker profiles of COPD patients and asthmatic patients. Occupational exposure induces a systemic proinflammatory state with increased levels of acute-phase proteins in stable COPD patients. MMP-9 and IL-1β concentrations are increased in induced sputum of never smokers with COPD, which is associated with occupational exposure.

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Section: Discussionmentioning

confidence: 99%

Comparison of biomarkers in serum and induced sputum of patients with occupational asthma and chronic obstructive pulmonary disease

Kleniewska

Walusiak‐Skorupa

Piotrowski

et al. 2016

Journal of Occupational Health

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“…e severity of COPD is of serious concern relative to the age of society, as the rate of occurrence is higher in older individuals than in younger individuals, and globally, the average age of societies is increasing. In particular, there are many opportunities through which people can come into contact with the COPD irritants, such as tobacco smoke, air pollution, and occupational dusts and fumes; subsequently, COPD onset in the pulmonary system is irreversible [6] and this disease leads to severe problems. At present, the drugs for COPD treatment, including bronchodilators and corticosteroids, have many adverse effects [19,20].…”

Section: Discussionmentioning

confidence: 99%

“…In December 2017, the World Health Organization (WHO) reported that chronic obstructive pulmonary disease (COPD) was the third most common cause of death globally, responsible for approximately 5% of total deaths [1]. Patients with COPD typically undergo changes in the respiratory system, such as neutrophil infiltration near bronchoalveolar spaces [2,3], mucous hypersecretion [4], fibrosis around the small airways [5], and alveolar wall destruction (emphysema) [6]; these changes can lead to gas exchange abnormalities, apnea, and, ultimately, death [7].…”

Section: Introductionmentioning

confidence: 99%

“…As COPD is an incurable disease in which the patients' lungs are irreversibly damaged [6], conventional therapies that suppress the symptoms of COPD are commonly used. However, these result in severe adverse effects, such as airway wall thickness through bronchodilation [19], growth suppression in children, hypertension, and peptic ulcers, because of the use of corticosteroids [20].…”

Section: Introductionmentioning

confidence: 99%

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Herbal Medication, Macmoondong Decoction, Attenuates LPS‐Induced COPD in Small Airways via TGF‐β, CCL‐2, and CXCL1

Lee

Kang

Bae

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Chronic obstructive pulmonary disease (COPD) is an incurable disease related to the respiratory system. A 2017 report by the World Health Organization stated that it was the third most common cause of death in 2015. Macmoondong decoction is a prescription that has been used widely in Korea for the treatment of respiratory diseases, but there have been few investigations into the therapeutic mechanism. To investigate the anti-COPD effect of macmoondong decoction, the animals were divided into five treatment groups: control; COPD-induced control; Spiriva; 150 mg/kg macmoondong decoction; and 1500 mg/kg macmoondong decoction. Changes typically observed in COPD, such as the populations of WBC and neutrophils in BALF, the level of IgE in serum, morphological changes, the DNA levels, and the protein expression of cytokines and chemokines (TGF-β, CCL-2, CXCL1, and CXCL11) in the pulmonary system, were evaluated. Macmoondong decoction inhibited the populations of WBC and neutrophils in BALF and the level of IgE in serum. Dose-dependent prevention of the pulmonary morphological changes, such as emphysema and airway fibrosis, was observed. Macmoondong decoction suppressed the expression of DNA and proteins related to the occurrence of COPD, such as TGF-β, CCL-2, CXCL1, and CXCL11. In particular, the expression of TGF-β, CCL-2, and CXCL1 was significantly suppressed by 1500 mg/kg macmoondong decoction treatment compared with Spiriva treatment. Macmoondong decoction exerted an anti-COPD effect, and the mechanism of its action may be the suppression of TGF-β, CCL-2, CXCL1, and CXCL11 expression, which occurred in a dose-dependent manner. The mechanism of action of macmoondong decoction may be the dose-dependent suppression of TGF-β, CCL-2, CXCL1, and CXCL11, with TGF-β, CCL-2, and CXCL1 as the potential key factors involved in COPD suppression.

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“…Entre de las principales quimiocinas: CCL2, CXCL1, CXCL2, CXCL3, CXCL5, CXCL8, CXCL9, CXCL10 (esta última inducida por INFγ), CXCL11, CCL20, CXCR3, CCR3, CXCR1, CXCR5 y CXCR8 10,16,21 En monocitos y células epiteliales, la participación de IL-32 inducida por INFγ activa 2 vías: la de NFκB y la de p38 MAPK, con producción de TNFα, IL-8 y MIP-2, involucradas en la progresión de la EPOC. La IL-32/TNFα tiene un papel clave en la progresión de la respuesta inmune inflamatoria y obstrucción en la EPOC.…”

Section: Atrofia Muscularunclassified

Inmunopatología de la enfermedad pulmonar obstructiva crónica

Martínez-Aguilar

Vargas-Camaño

Hernandez-Pliego

et al. 2017

RAM

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Este artículo debe citarse como: Martínez-Aguilar NE, Vargas-Camaño ME, Hernández-Pliego RR, ChaiaSemerena GM, Pérez-Chavira MR. Inmunopatología de la enfermedad pulmonar obstructiva crónica. Rev Alerg Mex. 2017;64(3):327-346 AbstractChronic obstructive pulmonary disease (COPD) is a common, preventable and treatable condition that has a complex pathophysiology and an even more complex immunopathological process. The purpose of this review was to analyze COPD immunopathological aspects, which was addressed by undertaking a literature search for the most relevant documents indexed in the PubMed database over the last 10 years. Different conclusions could be drawn: in COPD immunopathology there are immune and non-immune inflammatory changes with oxidative stress imbalance, there are alterations in the protease/anti-protease ratio caused by direct and indirect genetic and epigeneticenvironmental defects; COPD produces irreversible tissue damage and chronic inflammation with tissue repair alteration, which induces chronic obstruction of the airway, bronchitis and systemic damage. Most common resulting comorbidities include cardiovascular disease, metabolic syndrome, osteoporosis, depression, musculoskeletal dysfunction, increased biological age, lung cancer and other types of malignancies. In the conception of COPD, recognizing that it is a nontransmittable and preventable disease is indispensable.

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Novel aspects of pathogenesis and regeneration mechanisms in COPD

Cited by 112 publications

References 214 publications

Comparison of biomarkers in serum and induced sputum of patients with occupational asthma and chronic obstructive pulmonary disease

Comparison of biomarkers in serum and induced sputum of patients with occupational asthma and chronic obstructive pulmonary disease

Herbal Medication, Macmoondong Decoction, Attenuates LPS‐Induced COPD in Small Airways via TGF‐β, CCL‐2, and CXCL1

Inmunopatología de la enfermedad pulmonar obstructiva crónica

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