Novel aspects of muscle involvement in immune-mediated inflammatory arthropathies and connective tissue diseases

Mogyoróssy, Sándor; Nagy‐Vincze, Melinda; Griger, Zoltán; Dankó, Katalin; Szabó, Nóra Anna; Szekanecz, Zoltán; Szűcs, Gabriella; Szántó, Antónia; Bodoki, Levente

doi:10.1016/j.autrev.2023.103311

Cited by 3 publications

(2 citation statements)

References 78 publications

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“…[1,2] The inflammatory response is redness, pain, swelling, and organ dysfunction. [3,4] Thus, controlling the development of inflammation processes as early as possible is a promising strategy for treatment IDs. However, traditional treatment is based on anti-inflammatory and immunosuppressive drugs, which are palliative and provide short-term relief with serious side effects.…”

Section: Introductionmentioning

confidence: 99%

Triple Cross‐linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF‐κB and MAPK Signaling Pathways

Wang,

Liu,

Sun

et al. 2023

Advanced Science

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Modulating the inflammatory microenvironment can inhibit the process of inflammatory diseases (IDs). A tri‐cross‐linked inflammatory microenvironment‐responsive hydrogel with ideal mechanical properties achieves triggerable and sustained drug delivery and regulates the inflammatory microenvironment. Here, this study develops an inflammatory microenvironment‐responsive hydrogel (OD‐PP@SeNPs) composed of phenylboronic acid grafted polylysine (PP), oxidized dextran (OD), and selenium nanoparticles (SeNPs). The introduction of SeNPs as initiators and nano‐fillers into the hydrogel results in extra cross‐linking of the polymer network through hydrogen bonding. Based on Schiff base bonds, Phenylboronate ester bonds, and hydrogen bonds, a reactive oxygen species (ROS)/pH dual responsive hydrogel with a triple‐network is achieved. The hydrogel has injectable, self‐healing, adhesion, outstanding flexibility, suitable swelling capacity, optimal biodegradability, excellent stimuli‐responsive active substance release performance, and prominent biocompatibility. Most importantly, the hydrogel with ROS scavenging and pH‐regulating ability protects cells from oxidative stress and induces macrophages into M2 polarization to reduce inflammatory cytokines through PI3K/AKT/NF‐κB and MAPK pathways, exerting anti‐inflammatory effects and reshaping the inflammatory microenvironment, thereby effectively treating typical IDs, including S. aureus infected wound and rheumatoid arthritis in rats. In conclusion, this dynamically responsive injectable hydrogel with a triple‐network structure provides an effective strategy to treat IDs, holding great promise in clinical application.

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Section: Introductionmentioning

confidence: 99%

Triple Cross‐linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF‐κB and MAPK Signaling Pathways

Wang,

Liu,

Sun

et al. 2023

Advanced Science

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show abstract

“…The pathogenic role of anti-cN1A in sIBM remains elusive, though lately attempts have been made to assess its impending pathogenicity [1]. How myopathy is also initiated in autoimmune rheumatic diseases and whether common pathophysiologic mechanisms do really exist are not yet clear [3][4][5][6]. Very recently, Yamashita et al [7] injected wild-type C57BL6 mice with three of the immunodominant cN1A peptides.…”

mentioning

confidence: 99%

On the role of anti-cN1A antibodies in sporadic inclusion body myositis and beyond: a challenging task full of surprises

Patrikiou,

Liaskos,

Bogdanos

2024

Reumatologia

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Isoliquiritigenin inhibits apoptosis and ameliorates oxidative stress in rheumatoid arthritis chondrocytes through the Nrf2/HO-1-mediated pathway

Hung,

Chen,

et al. 2024

Biomedicine & Pharmacotherapy

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Novel aspects of muscle involvement in immune-mediated inflammatory arthropathies and connective tissue diseases

Cited by 3 publications

References 78 publications

Triple Cross‐linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF‐κB and MAPK Signaling Pathways

Triple Cross‐linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF‐κB and MAPK Signaling Pathways

On the role of anti-cN1A antibodies in sporadic inclusion body myositis and beyond: a challenging task full of surprises

Isoliquiritigenin inhibits apoptosis and ameliorates oxidative stress in rheumatoid arthritis chondrocytes through the Nrf2/HO-1-mediated pathway

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