Novel archetype in cancer therapeutics: exploring prospective of phytonanocarriers

Yadav, Nisha; Singh, Deependra; Rawat, Mamta; Sangwan, Rajender Singh

doi:10.1007/s13205-022-03372-3

Cited by 5 publications

(5 citation statements)

References 158 publications

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“…There is a large body of information and scientific validation of activities reported for various plants parts of W. somnifera . Several activities including neuroprotection (Ahmad, Samuel, e al, 2016, Ahmad, Arya, et al, 2016), inflammatory (Chauhan et al, 2022), bone health (Khedgikar et al, 2013) anti‐cancer (Siddique et al, 2014; Sivasankarapillai et al, 2020; Yadav et al, 2022), antioxidant and, anti‐diabetic (Mikulska et al 2023) anti‐viral specially in Covid management (Kasarla et al, 2022) have been illustrated earlier wherein plant has shown promising effect (Fig. 1).…”

Section: Withania Somnifera: Therapeutically Potential Activitiesmentioning

confidence: 99%

Phyto‐therapeutic potential of Withania somnifera: Molecular mechanism and health implications

Yadav,

Tripathi,

Sangwan

2024

Phytotherapy Research

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Withania somnifera, the plant named Indian ginseng, Ashwagandha, or winter cherry, has been used since ancient times to cure various health ailments. Withania somnifera is rich in constituents belonging to chemical classes like alkaloids, saponins, flavonoids, phenolic acids, and withanolides. Several chemotypes were identified based on their phytochemical composition and credited for their multiple bioactivities. Besides, exhibiting neuroprotective, immunomodulatory, adaptogenic, anti‐stress, bone health, plant has shown promising anti‐cancer properties. Several withanolides have been reported to play a crucial role in cancer; they target cancer cells by different mechanisms such as modulating the expression of tumor suppressor genes, apoptosis, telomerase expression, and regulating cell signaling pathway. Though, many treatments are available for cancer; however, to date, no assured reliable cure for cancer is made available. Additionally, synthetic drugs may lead to development of resistance in time; therefore, focus on new and natural drugs for cancer therapeutics may prove a longtime effective alternative. This current report is a comprehensive combined analysis upto 2023 with articles focused on bio‐activities of plant Withania somnifera from various sources, including national and international government sources. This review focuses on understanding of various mechanisms and pathways to inhibit uncontrolled cell growth by W. somnifera bioactives, as reported in literature. This review provides a recent updated status of the W. somnifera on pharmacological properties in general and anti‐cancer in particular and may provide a guiding resource for researchers associated with natural product‐based cancer research and healthcare management.

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Section: Withania Somnifera: Therapeutically Potential Activitiesmentioning

confidence: 99%

Phyto‐therapeutic potential of Withania somnifera: Molecular mechanism and health implications

Yadav,

Tripathi,

Sangwan

2024

Phytotherapy Research

Self Cite

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“…Recently, natural products in medicinal plants, such as alkaloids, flavonoids, terpenoids, carotenoids, and glycosides, possess therapeutic effects and are used as new therapeutic drugs. 716 – 718 In clinic, herbal products are combined with conventional drugs to improve pharmacological effects. Active ingredients or drug leads from natural products have been a key source but their identification is always a challenge due to their complexity.…”

Section: Active Ingredients Discoverymentioning

confidence: 99%

Small molecule metabolites: discovery of biomarkers and therapeutic targets

Qiu

Cai

et al. 2023

Sig Transduct Target Ther

154

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Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject’s phenotypic informative dimension, are useful for predicting diagnosis and prognosis of diseases as well as monitoring treatments. The lack of early biomarkers could lead to poor diagnosis and serious outcomes. Therefore, noninvasive diagnosis and monitoring methods with high specificity and selectivity are desperately needed. Small molecule metabolites-based metabolomics has become a specialized tool for metabolic biomarker and pathway analysis, for revealing possible mechanisms of human various diseases and deciphering therapeutic potentials. It could help identify functional biomarkers related to phenotypic variation and delineate biochemical pathways changes as early indicators of pathological dysfunction and damage prior to disease development. Recently, scientists have established a large number of metabolic profiles to reveal the underlying mechanisms and metabolic networks for therapeutic target exploration in biomedicine. This review summarized the metabolic analysis on the potential value of small-molecule candidate metabolites as biomarkers with clinical events, which may lead to better diagnosis, prognosis, drug screening and treatment. We also discuss challenges that need to be addressed to fuel the next wave of breakthroughs.

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“…Humans rely heavily on plants as a source of food, feed, traditional medicine, and medication. According to current statistics, at least 35 -40 thousand different plant species have been utilized for medical purposes [1]. As there are safety concerns with the adverse effects of synthetic chemicals and their medications, the demand for herbal therapies is steadily expanding.…”

Section: Introductionmentioning

confidence: 99%

Exploring Natural Medicinal Resources: Comparative Study on Antioxidant and Cytotoxicity Potential

2024

Curr Res Cmpl Alt Med

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Background: Plants have served as the foundation of traditional medicines. The myriad of compounds belonging to chemical classes found in plants have been associated with various therapeutic potential. Recent research reports showed that plant-derived phenolic compounds possess great antioxidant properties and exhibit cytotoxic potential as well. Southern Haryana has a rich diversity of plants many of which remained under-explored for their therapeutic properties. Objective: In the present study, selected widely growing plants in the region were evaluated for their antioxidant and cytotoxicity potential. Methods: The antioxidant activity was evaluated using (2,2-dyphenyl-1-picrylhydrazyl (DPPH) scavenging, ferric reducing antioxidant power (FRAP) assay, and cytotoxic potential was evaluated using (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) (MTT) assay. Results: Glycyrrhiza glabra showed maximum radical scavenging activity whereas Cinnamomum verum was found to have maximum antioxidant potential as estimated by FRAP assay i.e., range from 0.8 to 1 mg FSE/g DW. Tectona grandis has maximum phenolic content with a range of 30 to 35 ± 3.01 mg GAE/g DW). The maximum flavonoid content was found in the Saraca asoca. The highest antioxidant potential was shown by Fraxinus excelsior and Cinnamon verum. Conclusion: This study demonstrated that the widely growing plants could be a potential source of natural antioxidants and selected plants may further prove beneficial in targeting diseases associated with oxidative stress. Plants have the potential to be a long-term sustainable resource of bioactive chemicals. The present study also exhibited that the therapeutic potential of plants is highly reliant on the type of plant material used.

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Novel archetype in cancer therapeutics: exploring prospective of phytonanocarriers

Cited by 5 publications

References 158 publications

Phyto‐therapeutic potential of Withania somnifera: Molecular mechanism and health implications

Phyto‐therapeutic potential of Withania somnifera: Molecular mechanism and health implications

Small molecule metabolites: discovery of biomarkers and therapeutic targets

Exploring Natural Medicinal Resources: Comparative Study on Antioxidant and Cytotoxicity Potential

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