Novel approaches using mesenchymal stem cells for curing peripheral nerve injuries

Yousefi, Farzad; Arab, Fahimeh Lavi; Nikkhah, Karim; Amiri, Houshang; Mahmoudi, Mahmoud

doi:10.1016/j.lfs.2019.01.052

Cited by 48 publications

(62 citation statements)

References 129 publications

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“…Current peripheral nerve stem cell literature exhibits wide variability in animal models, nerve injury type, stem cell source, differentiation protocols, cell‐delivery methods, and assessment of nerve regeneration. In particular, variations in the timing of diverse outcome measures between different stem cell treatment modalities make specific treatments difficult to assess . These inconsistencies make it extremely difficult to establish clear conclusions about efficacy or safety in a clinical population.…”

Section: Current State Of Clinical Translationmentioning

confidence: 99%

“…In particular, variations in the timing of diverse outcome measures between different stem cell treatment modalities make specific treatments difficult to assess. 35,37 These inconsistencies make it extremely difficult to establish clear conclusions about efficacy or safety in a clinical population. In addition, ethical considerations are a necessity when translating research from the bench to bedside.…”

Section: Current State Of Clinical Translationmentioning

confidence: 99%

“…We are also cognizant of the fact that embryonic stem cells generally have a higher regenerative capacity and are less lineage committed than adult precursor and/or stem cells . There is a growing body of evidence in preclinical animal studies showing that stem cells play a positive role in the regeneration of peripheral nerves after injury . These effects are thought to be based on the ability of transplanted stem cells to promote regeneration by cell differentiation into tissue‐specific cell types, signaling through cell‐to‐cell contact, and/or sustained release of neurotrophic factors .…”

Section: Introductionmentioning

confidence: 99%

“…30,31 There is a growing body of evidence in preclinical animal studies showing that stem cells play a positive role in the regeneration of peripheral nerves after injury. [32][33][34][35][36][37] These effects are thought to be based on the ability of transplanted stem cells to promote regeneration by cell differentiation into tissuespecific cell types, [38][39][40] signaling through cell-to-cell contact, and/or sustained release of neurotrophic factors. 27,41,42 A number of stem cell types with varying phenotypic and gene expression profiles have been investigated.…”

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confidence: 99%

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Stem‐cell–based therapies to enhance peripheral nerve regeneration

et al. 2019

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Peripheral nerve injury remains a major cause of morbidity in trauma patients. Despite advances in microsurgical techniques and improved understanding of nerve regeneration, obtaining satisfactory outcomes after peripheral nerve injury remains a difficult clinical problem. There is a growing body of evidence in preclinical animal studies demonstrating the supportive role of stem cells in peripheral nerve regeneration after injury. The characteristics of both mesoderm‐derived and ectoderm‐derived stem cell types and their role in peripheral nerve regeneration are discussed, specifically focusing on the presentation of both foundational laboratory studies and translational applications. The current state of clinical translation is presented, with an emphasis on both ethical considerations of using stems cells in humans and current governmental regulatory policies. Current advancements in cell‐based therapies represent a promising future with regard to supporting nerve regeneration and achieving significant functional recovery after debilitating nerve injuries.

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Section: Current State Of Clinical Translationmentioning

confidence: 99%

Section: Current State Of Clinical Translationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Stem‐cell–based therapies to enhance peripheral nerve regeneration

et al. 2019

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“…Stem cell transplantation is another promising strategy for nerve repair. Among various types of stem cells, mesenchymal stem cells (MSCs) have been used widely as tissue‐engineering seed cells to repair nerve injury in preclinical research 16,17 . MSCs can promote nerve regeneration after transplantation 1,18–20 .…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging of enhanced nerve repair with mesenchymal stem cells combined with microenvironment immunomodulation in neurotmesis

et al. 2020

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Introduction:The immuno-microenvironment of injured nerves adversely affects mesenchymal stem cell (MSC) therapy for neurotmesis. Magnetic resonance imaging (MRI) can be used noninvasively to monitor nerve degeneration and regeneration. The aim of this study was to investigate nerve repair after MSC transplantation combined with microenvironment immunomodulation in neurotmesis by using multiparametric MRI.Methods: Rats with sciatic nerve transection and surgical coaptation were treated with MSCs combined with immunomodulation or MSCs alone. Serial multiparametric MRI examinations were performed over an 8-week period after surgery.Results: Nerves treated with MSCs combined with immunomodulation showed better functional recovery, rapid recovery of nerve T2, fractional anisotropy and radial diffusivity values, and more rapid restoration of the fiber tracks than nerves treated with MSCs alone.Discussion: Transplantation of MSCs in combination with immunomodulation can exert a synergistic repair effect on neurotmesis, which can be monitored by multiparametric MRI. K E Y W O R D Simmunomodulation, magnetic resonance imaging, mesenchymal stem cells, peripheral nerve injuries, tacrolimus, toll-like receptors Abbreviations: AD, axial diffusivity; BDNF, brain-derived neurotrophic factor; DTI, diffusion tensor imaging; DTT, diffusion tensor tractography; ELISA, enzyme-linked immunosorbent assay; FA, fractional anisotropy; FKBP, FK-binding protein; GDNF, glial cell-derived neurotrophic factor; GFP, green fluorescent protein; LPS, lipopolysaccharide; MD, mean diffusivity; MRI, magnetic resonance imaging; MSC, mesenchymal stem cell; PBS, phosphate-buffered saline; RD, radial diffusivity; SD, Sprague-Dawley; SFI, sciatic nerve function index; SPRR1A, small proline-rich protein 1A; TLR4, toll-like receptor 4; TNF-α, tumor necrosis factor-α.Zehong Yang and Chushan Zheng contributed equally to this work.

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