Novel approaches to microfluidic components in high-end medical applications

Goettsche, T.; Kohnle, J.; Willmann, Michael; Ernst, H.; Messner, S.; Steger, R.; Storz, M.; Lang, Walter; Zengerle, Roland; Sandmaier, H.

doi:10.1109/sensor.2003.1215550

Cited by 4 publications

(4 citation statements)

References 2 publications

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“…In the second approach, the flow direction is controlled by injecting additional streams of fluid into the channel, which changes the lateral position of the stream within the channel on which flow direction depends. Goettsche et al [37] developed an active control method where they used a piezoactuated micromachined silicone microvalve to control flow rate with a high degree of precision for drug delivery applications. Centrifugal platforms have been considered as elegant means to transport fluids in these labs-on-a-chip.…”

Section: Flow Control In Microchannelsmentioning

confidence: 99%

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Characterization of liquid flows in microfluidic systems

Bayraktar¹,

Pidugu²

2006

International Journal of Heat and Mass Transfer

194

106

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Section: Flow Control In Microchannelsmentioning

confidence: 99%

“…Use of flexible materials 2. Flow control in microchannels (a) Flow control and separation [4,37] Leaks in microfluidic valves. Low separation efficiencies (b) Flow mixing [4,41] Enhancing mixing at micro scales, modeling of active mixtures 3.…”

Section: Velocimetry Techniques Using Dye Tracersmentioning

confidence: 99%

Characterization of liquid flows in microfluidic systems

Bayraktar¹,

Pidugu²

2006

International Journal of Heat and Mass Transfer

194

106

View full text Add to dashboard Cite

“…Secondly, a noticeable large number of micropumps-perhaps even the majority-are designed for life science applications. Here, small volumes have to be displaced for applications such as drug delivery systems, micro-total-analysis systems (µTAS) or biochips [9,[13][14][15][16][17][18][19][20][25][26][27][28][29][30][31][32][33][34][35]. For these applications, micropumps are predestinated due to their small size, precise metering capability, small power consumption and ability of system integration.…”

Section: Introductionmentioning

confidence: 99%

A novel two-stage backpressure-independent micropump: modeling and characterization

Geipel

Doll

Jantscheff

et al. 2007

J. Micromech. Microeng.

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A novel design of a piezoelectric silicon micropump is proposed, which provides a constant flow rate over a wide backpressure range of up to 30 kPa. This highly appreciable feature is based on a new serial arrangement of two active valves and relies on both an appropriate electrical actuation sequence of the piezo-actuators and an immanent limitation of the membrane deflection by the valve seats. The design is optimized for the low flow regime ranging from 0.1 to 50 µl min−1. A detailed lumped-parameter model is derived in order to reveal the physics behind this pumping principle and to identify the optimum control scheme. For the fabrication of our device, a comparably simple and robust 2-wafer process is utilized. A thorough experimental investigation demonstrates the high performance of the micropump. The backpressure independence of the flow rate enables high-resolution volumetric dosing within the aforementioned flow range. The stroke volume and hence the resolution of the micropump is adjustable via the upstroke voltage of the actuator between 50 and 200 nl. Depending on this setting typical actuation frequencies range from 0.05 to 5 Hz and the flow rate scales proportional to the frequency within that frequency range.

show abstract

Section: Introductionmentioning

confidence: 99%

Geophysical turbulence

Monin¹

1983

Russ. Math. Surv.

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A novel design of a piezoelectric silicon micropump is proposed, which provides a constant flow rate over a wide backpressure range of up to 30 kPa. This highly appreciable feature is based on a new serial arrangement of two active valves and relies on both an appropriate electrical actuation sequence of the piezo-actuators and an immanent limitation of the membrane deflection by the valve seats. The design is optimized for the low flow regime ranging from 0.1 to 50 µl min −1 . A detailed lumped-parameter model is derived in order to reveal the physics behind this pumping principle and to identify the optimum control scheme. For the fabrication of our device, a comparably simple and robust 2-wafer process is utilized. A thorough experimental investigation demonstrates the high performance of the micropump. The backpressure independence of the flow rate enables high-resolution volumetric dosing within the aforementioned flow range. The stroke volume and hence the resolution of the micropump is adjustable via the upstroke voltage of the actuator between 50 and 200 nl. Depending on this setting typical actuation frequencies range from 0.05 to 5 Hz and the flow rate scales proportional to the frequency within that frequency range.

show abstract

Novel approaches to microfluidic components in high-end medical applications

Cited by 4 publications

References 2 publications

Characterization of liquid flows in microfluidic systems

Characterization of liquid flows in microfluidic systems

A novel two-stage backpressure-independent micropump: modeling and characterization

Geophysical turbulence

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