Novel approaches to glioma drug design and drug screening

Patil, Shivaputra A.; Hosni-Ahmed, Amira; Jones, Terreia S.; Patil, Renukadevi; Pfeffer, Lawrence M.; Miller, Duane D.

doi:10.1517/17460441.2013.807248

Cited by 41 publications

(42 citation statements)

References 115 publications

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“…1 Temozolomide (TMZ), the most commonly used chemotherapy for glioma, and other current anti-glioma drugs are associated with strong side effects, poor drug delivery, and persistent chemoresistance. 2 There is therefore a need to develop novel anti-glioma agents for the treatment of malignant glioma. Natural products are highly significant sources of novel drug leads, especially the anticancer drugs.…”

mentioning

confidence: 99%

Bioactive triterpenoid saponins and phenolic compounds against glioma cells

Liang

et al. 2014

Bioorganic & Medicinal Chemistry Letters

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confidence: 99%

Bioactive triterpenoid saponins and phenolic compounds against glioma cells

Liang

et al. 2014

Bioorganic & Medicinal Chemistry Letters

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“…Chemotherapy is an important adjunctive therapy for treating gliomas and temozolomide (TMZ) is the only drug that has been independently used for the treatment of gliomas. The efficacy of the currently used anticancer drugs including TMZ is limited (Chamberlain 2010;Patil et al 2013). There is therefore a need to discover lead compounds for the development of novel anti-glioma drugs.…”

Section: Introductionmentioning

confidence: 99%

A new curvularin glycoside and its cytotoxic and antibacterial analogues from marine actinomycete Pseudonocardia sp. HS7

Anjum

Song

et al. 2015

Natural Product Research

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Five curvularin macrolides (1-5) were isolated from the cultured broth of marine actinomycete Pseudonocardia sp. HS7 that was obtained from the cloacal aperture of sea cucumber Holothuria moebii. The structures of these isolates were characterized as (11S,15R)-11-hydroxycurvularin (1), (11R,15R)-11-hydroxycurvularin (2), curvularin-7-O-α-D-glucopyranoside (3), trans-dehydrocurvularin (4) and curvularin (5) based on their NMR and HRESIMS data as well as chemical degradation. Compound 3 is a new macrolide with a rare α-D-glucopyranose substituent. Compounds 1-4, 5a and 5c (the acyl products of 5), suppressed the proliferation of all six tested cancer cell lines and 4 is the most active compound with IC50 values ranging from 0.59 to 3.39 μM. The 11-hydroxycurvularins 1 and 2 also showed antibacterial activity inhibiting the growth of Escherichia coli.

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“…1 While chemotherapy has played an important role in treating gliomas, temozolomide (TMZ) is the only drug that has been alone used for the treatment of gliomas, and the efficacy of TMZ, as well as other current drugs remains limited. 1,2 There is a need to discover lead compounds for the development of novel anti-glioma drugs. Natural products are significant sources of new drug leads.…”

Section: Introductionmentioning

confidence: 99%