Novel Approaches in Pilonidal Sinus Treatment

Işık, Arda; İdiz, Oğuz; Fırat, Deniz

doi:10.14712/23362936.2016.15

Cited by 49 publications

(40 citation statements)

References 41 publications

(45 reference statements)

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“…Studies have shown that chemokines play an important role in tumor growth and angiogenesis. 33,34 Studies have shown that calcium signaling pathways are associated with the development and progression of various cancers, such as lung adenocarcinoma, 35 breast cancer, 36 colorectal cancer, 37 Burkitt's lymphoma, 38 and others. 2 genes were upregulated genes and 3 genes were downregulated genes.…”

Section: Discussionmentioning

confidence: 99%

Developing DNA methylation‐based prognostic biomarkers of acute myeloid leukemia

Gao

Zhuang

Zhou

et al. 2018

J of Cellular Biochemistry

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Acute myeloid leukemia (AML) is a heterogeneous clonal neoplasm characterized by complex genomic alterations. The incidence of AML increases with age, and most cases experience serious illness and poor prognosis. To explore the relationship between abnormal DNA methylation and the occurrence and development of AML based on the Gene Expression Database (GEO), this study extracted data related to methylation in AML and identified a methylated CpG site that was significantly different in terms of expression and distribution between the primary cells of AML patients, and hematopoietic stem/progenitor cells from normal bone marrow. To further investigate the differences caused by the dysfunction of methylation sites, bioinformatics analysis was used to screen methylation-related biomarkers, and the potential prognostic genes were selected by univariate and multivariate Cox proportional hazards regressions. Finally, five independent prognostic indicators were identified. In addition, these results provide new insight into the molecular mechanisms of methylation.

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Section: Discussionmentioning

confidence: 99%

Developing DNA methylation‐based prognostic biomarkers of acute myeloid leukemia

Gao

Zhuang

Zhou

et al. 2018

J of Cellular Biochemistry

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“…The drainage of pilonidal sinus abscess should be acknowledged as an essential part of therapy to eliminate the primary focus of the infection 14 18. Several surgical methods are used to treat pilonidal sinus, such as primary suture, lay open and the flap plasty techniques 19. Each method has a certain recurrence rate and, therefore, no standard treatment approach has been determined, despite the high incidence of pilonidal disease affecting young population 19…”

Section: Discussionmentioning

confidence: 99%

Teenage boy with high fever and rash: what could we be missing?

Oliveira

Costa²,

Costa³

et al. 2018

BMJ Case Reports

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A 15-year-old boy was admitted to a local hospital with high fever, generalised rash and a mild sore throat. He was started on intravenous flucloxacillin and 12 hours later develops a sustained low diastolic blood pressure (DBP), unresponsive to fluid volume expansion and cardiovascular support with dopamine. Intravenous clindamycin was added and transportation to paediatric intensive care unit arranged. Dopamine dosing was increased and norepinephrine infusion was added subsequently with immediate stabilisation of DBP. A sacrococcygeal pilonidal abscess was identified, requiring prompt surgical drainage. The microbiological culture of abscess material was positive for an enterotoxin-producing He was free of symptoms after 4 days. This case report summarises a potential severe complication of the pilonidal disease.

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“…In patients with extensive perianal disease or rectal involvement, transperineal completion proctectomy is often feasible, thereby avoiding relaparotomy. By using a close rectal intersphincteric resection, damage to the pelvic autonomic nerves is avoided [19,[53][54][55][56][57][58][59].…”

Section: New Developmentsmentioning

confidence: 99%

Surgical Management of Primary Crohn’s Disease

Makni¹

2017

Austin J Gastroenterol

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Inflammatory bowel disease is a chronic gastrointestinal condition that is characterized by chronic gastrointestinal inflammation. The management of Crohn's disease is complex and requires skill, knowledge and experience with current advances in the field. Over the past several years, there have been a number of achievements and progress made in the care and management of this disorder. The diagnostic tools have greatly improved. The therapeutic armamentarium has expanded. The genetics of IBD has become more detailed and the role of the gut microbiome has been better defined. The evolution of biological agents has revolutionized the way we approach this disease. However, surgery is still required in more than 80% of patients with Crohn's disease (CD). This article aims to study the epidemiological, anatomical and therapeutic principles of surgical forms of CD. Keywords:Crohn's disease; Surgery; Recurrence; Stricture; Fistula IntroductionSurgery is required in more than 80% of patients with Crohn's disease (CD) [1]. The aim of surgery is not to cure the disease, which evolves in most cases to the recurrence of the remaining intestine [2]. Surgical treatment of intestinal lesions caused by CD is guided by two main criteria: operate only complicated forms, and refractory to medical treatment, and perform an intestinal resection as limited as possible, removing only lesions responsible for the symptoms observed. Indeed, perineal CD is problematic as regards to the diagnostic, prognostic and specific management. Over the past several years, there have been a number of achievements and progress made in the care and management of this disorder. However, surgery is still required in more than 80% of patients with Crohn's disease (CD). This article aims to study the epidemiological, anatomical and therapeutic principles of surgical forms of CD. The indications of surgical managementMultidisciplinary approach is now mandatory to discuss the therapeutic strategy and the time for surgery. The indication for surgery in CD depends on a number of factors-complications, clinical course, relapse and location. We could say that surgery is timely in any of the following situations: failure of medical treatment, onset of specific complications related to the disease or to pharmacological treatment, dysplasia or cancer and stagnated or retarded growth in children [3,4]. Chronic complications of Crohn's diseaseSurgery in the era of medical management: Today's, medical management (immunosuppressants, biological therapies) has been used increasingly and was initiated much earlier during the course of CD. However, this evolving therapeutic strategy was not associated with a decrease in the need for surgery or in a decrease of the occurrence of intestinal complications. The real benefit is that large intestinal resections became more unusual [5].Time for surgery: Identifying the best time for surgery is not always an easy task. In order to determine the best time for surgery

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Novel Approaches in Pilonidal Sinus Treatment

Cited by 49 publications

References 41 publications

Developing DNA methylation‐based prognostic biomarkers of acute myeloid leukemia

Developing DNA methylation‐based prognostic biomarkers of acute myeloid leukemia

Teenage boy with high fever and rash: what could we be missing?

Surgical Management of Primary Crohn’s Disease

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