Novel Approaches in Ocular Drug Delivery-a Revolution

KAUSHIK, AYUSHI; Mazumder, Rupa; Padhi, Swarupanjali; Mazumder, Avijit; BUDHORI, RAJAT; MANORMA,; Paul, Swarnali Das

doi:10.22159/ijap.2022v14i3.44045

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…55 Also, Kaushika et al, showed the effect of the development of cubosomes, adopted to combat various ocular diseases. 56 Cubosome formulation increases the permeability coefficient of loaded dexamethasone via excised rabbit corneas. Gan L et al demonstrated the effect that cubosomes resulting in an increase in dexamethasone amount in compared to eye drops, in aqueous humor during a pharmacokinetic study.…”

Section: Ocular Applicationsmentioning

confidence: 98%

Cubosomes: Recent Developments and Applications from a Global Perspective

Mishra,

Aher,

Nandgude

et al. 2023

IJDDT

View full text Add to dashboard Cite

Liquid crystalline cubosomes are self-assembly of aqueous lipid and surfactant mixture. They are discrete and sub-micron in size. It is an innovative lipid-based nanosystem resembling well-known vesicular systems including niosomes and liposomes. Cubic phases incorporate lipophobic, amphiphilic and hydrophilic, components through the utilization of a rounded bi-continuous lipid bilayer and water channels. Cubosomes contain lipids such as phytantriol (PHYT) and glycerol monooleate (GMO) which are amphiphilic in nature that are diffused in water and structured in 3-D as a “honeycomb” structure with suitable stabilizer (Poloxamer 407). Cubosomes are generated by mostly two techniques i.e., top-down, bottom-up methods. UV spectrophotometer, X-ray scattering, transmission electron microscopy, and photon correlation spectroscopy are used to characterize and evaluate cubosomes. They are commonly used in the administration of oral, ophthalmic, transdermal, and chemotherapeutic drugs. The liquid crystalline phase and bicontinuous cubic form nanoparticles are thoroughly discussed in this paper. In the current review search criterion used parameters affecting cubosomes bi-continuous lipid bilayer by top-down and bottom-up methods mostly. The sources referred from peer-reviewed recognized journals. Keywords used as filters were cubosomes, amphiphilic lipids, top-down, bottom-up, bicontinuous, GMO, and phytantriol (PHYT). For the purpose of a comprehensive update literature review over a range (1976–2023) has been conducted on the recent developments cubosomes system.

show abstract

Section: Ocular Applicationsmentioning

confidence: 98%

Cubosomes: Recent Developments and Applications from a Global Perspective

Mishra,

Aher,

Nandgude

et al. 2023

IJDDT

View full text Add to dashboard Cite

show abstract

“…The uses of these techniques for evaluation of herbal medicines has grown, as well as many herbal pharmacopoeias, now involves these techniques for the identification and standardization of phytoconstituents and phytoproducts. These techniques tells the quality and quantity of the phytoconstituents in plant medicine 10,11 . Structures of Quantified compounds (Gallic acid and Quercetin) are available in Figure 8.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of Gallic acid and Quercetin by HPTLC and In vitro Antioxidant activity of Averrhoa carambola Linn

2023

View full text Add to dashboard Cite

The preliminary phytochemical screening of ethanolic extracts of Averrhoa carambola (A. carambola) leaves were done using the standard protocol. The findings of phytochemical analysis exhibited the occurrence of Carbohydrates, Alkaloids, Steroids, Tannins, Vitamin C and flavonoids by using the Folin-Ciocalteu technique and the aluminum chloride colorimetric technique, respectively, the whole phenolic or flavonoid amounts were evaluated and were found 194.48±0.723 mg/g of dry extract as equivalent to gallic acid and 54.83±0.108 mg/g of dry extract as equivalent to quercetin respectively. In vitro, antioxidant activity was evaluated using 2,2-diphenlyl-1-picrylhydrazyl (DPPH), Hydrogen peroxide (H2O2), and Nitric oxide (NO) method. Ethanolic extract of A. carambola leaves showed good In vitro antioxidant action. Thin layer chromatography (TLC) of the ethanolic extract was carried out with gallic acid and quercetin as the reference biomarkers. HPTLC (High-Performance Thin Layer Chromatography technique was applied to detect spots and quantification for gallic acid and quercetin. The Rf values of gallic acid and quercetin were found 0.25 and 0.53 respectively. The amounts of gallic acid and quercetin were found to be 502.7 µg and 458.3 µg/100 mg of the ethanolic extract of A. carambola leaves separately.

show abstract

“…The most promising type of drug delivery technologies for ophthalmic applications is polymeric ophthalmic nanoparticles because they improve medication absorption [6,7]. The advantages of suggested nanomedicine in the treatment of diabetic retinopathy are highlighted by the employment of innovative nanoparticle-based drug delivery systems in conjunction with established therapeutic modalities [8].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Aspirin-Loaded Plga Nanoparticles for Ophthalmic Use

Pethe

SHANBHAG

SHERJE³

et al. 2023

Int J App Pharm

View full text Add to dashboard Cite

Objective: The objective of this work was to increase the bioavailability of Aspirin to the retina by increasing its bioavailability to blood. This was achieved by forming aspirin-loaded PLGA nanoparticles Methods: Aspirin-loaded PLGA nanoparticles were prepared by a solvent evaporation process. The PLGA was dissolved in the proper solvent and added dropwise to the Aspirin-albumin solution revolving at 3000 rpm. Glutaraldehyde was used as a cross-linker at 20% concentration. The nanoparticles were obtained after passing the solution through HPH and subsequent centrifugation. Results: The prepared nanoparticles were found to be spherical with the smooth surface as seen in SEM. and with a size of 160.9 nm. Aspirin-loaded PLGA nanoparticles showed in vitro drug release of 71.4 % and ex-vivo permeation of 66.2 %. The formulation was found to be stable for six months. Conclusion: The developed aspirin-loaded polymeric nanoparticles could be effective for the controlled delivery of aspirin in the early prevention of diabetic retinopathy.

show abstract

Novel Approaches in Ocular Drug Delivery-a Revolution

Cited by 3 publications

References 0 publications

Cubosomes: Recent Developments and Applications from a Global Perspective

Cubosomes: Recent Developments and Applications from a Global Perspective

Quantitative Analysis of Gallic acid and Quercetin by HPTLC and In vitro Antioxidant activity of Averrhoa carambola Linn

Formulation and Evaluation of Aspirin-Loaded Plga Nanoparticles for Ophthalmic Use

Contact Info

Product

Resources

About