Novel Approaches in Molecular Imaging and Neuroimaging of Fibromyalgia

Ricci, Marcos Desídérío; Cimini, Andrea; Fojaja, Maria Rosaria Grivet; Ullo, Mariacristina; Carabellese, Bruno; Frantellizzi, Viviana; Lubrano, Ennio

doi:10.3390/ijms232415519

Cited by 8 publications

(6 citation statements)

References 72 publications

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“…Brain imaging research supports the structural and functional similarities between FM and BD. Specifically, MRI in FM patients reveals reduced gray matter density in brain areas linked to pain transmission and processing ( 42 ), while functional MRI studies show enhanced activation in the pain matrix regions of their brains ( 43 ). In contrast, imaging studies in BD patients indicate certain structural and functional abnormalities in the prefrontal cortex, and an increased volume of the amygdala, which is associated with high activity levels during mood elevation phases ( 44 ).…”

Section: Discussionmentioning

confidence: 99%

Global trends and hotspots in pain associated with bipolar disorder in the last 20 years: a bibliometric analysis

Zhao,

Zhou,

Jiang

et al. 2024

Front. Neurol.

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PurposeThe prevalence of comorbid pain and Bipolar Disorder in clinical practice continues to be high, with an increasing number of related publications. However, no study has used bibliometric methods to analyze the research progress and knowledge structure in this field. Our research is dedicated to systematically exploring the global trends and focal points in scientific research on pain comorbidity with bipolar disorder from 2003 to 2023, with the goal of contributing to the field.MethodsRelevant publications in this field were retrieved from the Web of Science core collection database (WOSSCC). And we used VOSviewer, CiteSpace, and the R package “Bibliometrix” for bibliometric analysis.ResultsA total of 485 publications (including 360 articles and 125 reviews) from 66 countries, 1019 institutions, were included in this study. Univ Toront and Kings Coll London are the leading research institutions in this field. J Affect Disorders contributed the largest number of articles, and is the most co-cited journal. Of the 2,537 scholars who participated in the study, Stubbs B, Vancampfort D, and Abdin E had the largest number of articles. Stubbs B is the most co-cited author. “chronic pain,” “neuropathic pain,” “psychological pain” are the keywords in the research.ConclusionThis is the first bibliometric analysis of pain-related bipolar disorder. There is growing interest in the area of pain and comorbid bipolar disorder. Focusing on different types of pain in bipolar disorder and emphasizing pain management in bipolar disorder are research hotspots and future trends. The study of pain related bipolar disorder still has significant potential for development, and we look forward to more high-quality research in the future.

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Section: Discussionmentioning

confidence: 99%

Global trends and hotspots in pain associated with bipolar disorder in the last 20 years: a bibliometric analysis

Zhao,

Zhou,

Jiang

et al. 2024

Front. Neurol.

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“…Advancements in understanding supraspinal pain processing mechanisms are being made through a range of neuroimaging techniques. These include structural methods like magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) [ 17 ], molecular approaches such as magnetic resonance spectroscopy (MRS) and positron emission tomography (PET) [ 18 ], and functional imaging modalities such as functional magnetic resonance imaging (fMRI) [ 19 , 20 ]. Through these methods, altered activations in numerous brain regions involved in pain processing have been revealed: Prefrontal Cortex (PFC): Involved in executive functions such as decision-making, attention, and emotional regulation.…”

Section: Pathophysiologymentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation in Fibromyalgia: Exploring the Necessity of Neuronavigation for Targeting New Brain Regions

Velickovic,

Radunovic

2024

JPM

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Fibromyalgia and osteoarthritis are among the most prevalent rheumatic conditions worldwide. Nonpharmacological interventions have gained scientific endorsements as the preferred initial treatments before resorting to pharmacological modalities. Repetitive transcranial magnetic stimulation (rTMS) is among the most widely researched neuromodulation techniques, though it has not yet been officially recommended for fibromyalgia. This review aims to summarize the current evidence supporting rTMS for treating various fibromyalgia symptoms. Recent findings: High-frequency rTMS directed at the primary motor cortex (M1) has the strongest support in the literature for reducing pain intensity, with new research examining its long-term effectiveness. Nonetheless, some individuals may not respond to M1-targeted rTMS, and symptoms beyond pain can be prominent. Ongoing research aims to improve the efficacy of rTMS by exploring new brain targets, using innovative stimulation parameters, incorporating neuronavigation, and better identifying patients likely to benefit from this treatment. Summary: Noninvasive brain stimulation with rTMS over M1 is a well-tolerated treatment that can improve chronic pain and overall quality of life in fibromyalgia patients. However, the data are highly heterogeneous, with a limited level of evidence, posing a significant challenge to the inclusion of rTMS in official treatment guidelines. Research is ongoing to enhance its effectiveness, with future perspectives exploring its impact by targeting additional areas of the brain such as the medial prefrontal cortex, anterior cingulate cortex, and inferior parietal lobe, as well as selecting the right patients who could benefit from this treatment.

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“…A suppressed anterior PFC activity might hint at challenges related to decision-making and cognitive flexibility, potentially accounting for the so-called 'fibro fog' [29]. Meanwhile, the reduced OFC activation, a region pivotal for emotional processing and reward evaluation, may underscore emotional dysregulation observed in many FM patients [30].…”

Section: Subdued Activation In the Apfc And Ofcmentioning

confidence: 99%

Prefrontal Cortex Activation during Diaphragmatic Breathing in Women with Fibromyalgia: An fNIRS Case Report

Kim,

Jung,

Lee

2023

Phys Ther Rehabil Sci

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Objective: The present study is designed to delve deeper into the realm of fibromyalgia (FM) symptom management by investigating the effects of diaphragmatic breathing on the prefrontal cortex (PFC) in women diagnosed with FM. Using functional near-infrared spectroscopy (fNIRS), the study aims to capture real-time PFC activation patterns during the practice of diaphragmatic breathing. The overarching objective is to identify and understand the underlying neural mechanisms that may contribute to the observed clinical benefits of this relaxation technique. Design: A case report Methods: To achieve this, a twofold approach was adopted: First, the patient's breathing patterns were meticulously examined to detect any aberrations. Following this, fNIRS was employed, focusing on the activation dynamics within the PFC. Results: Our examination unveiled a notable breathing pattern disorder inherent to the FM patient. More intriguingly, the fNIRS analysis offered compelling insights: the ventrolateral prefrontal cortex (VLPFC) displayed increased activation. In stark contrast, regions of the anterior prefrontal cortex (aPFC) and orbitofrontal cortex (OFC) manifested decreased activity, especially when benchmarked against typical activations seen in healthy adults. Conclusions: These findings, derived from a nuanced examination of FM, underscore the condition's multifaceted nature. They highlight the imperative to look beyond conventional symptomatology and appreciate the profound neurological and physiological intricacies that define FM.

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Novel Approaches in Molecular Imaging and Neuroimaging of Fibromyalgia

Cited by 8 publications

References 72 publications

Global trends and hotspots in pain associated with bipolar disorder in the last 20 years: a bibliometric analysis

Global trends and hotspots in pain associated with bipolar disorder in the last 20 years: a bibliometric analysis

Repetitive Transcranial Magnetic Stimulation in Fibromyalgia: Exploring the Necessity of Neuronavigation for Targeting New Brain Regions

Prefrontal Cortex Activation during Diaphragmatic Breathing in Women with Fibromyalgia: An fNIRS Case Report

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