Novel approaches for therapy of chronic hepatitis C

Stauber, Rudolf; Stadlbauer, Vanessa

doi:10.1016/j.jcv.2006.02.003

Cited by 20 publications

(13 citation statements)

References 39 publications

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“…The most potent HCV protease inhibitory activity was observed on a dimeric compound (24). [7]. It is urgently needed to develop new agents against liver cancer and hepatitis C infection.…”

Section: Hcv Protease Inhibitionmentioning

confidence: 99%

“…Chronic hepatitis C is the leading cause for several liver diseases including hepatocellular carcinoma. The protease of hepatitis C virus (HCV) is an essential enzyme for the maturation of the virus and represents one of the attractive therapeutic targets for developing anti-HCV agents [7]. Previously, several series of oleanolic acid derivatives were synthesized in our laboratory and were investigated for their inhibitory activity on HIV protease [8,9].…”

Section: Introductionmentioning

confidence: 99%

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HCV Protease Inhibitory, Cytotoxic and Apoptosis-Inducing Effects of Oleanolic Acid Derivatives

Hattori

et al. 2009

J Pharm Pharm Sci

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-Purpose. To evaluate oleanolic acid derivatives on liver disease related bioactivities, 29 oleanolic acid derivatives of several series were tested for their inhibitory activity on hepatitis C viral protease as well as for their cytotoxic and apoptosis-inducing effects on Hep G2 cells. Results. The amino derivatives (17-19) showed potent cytotoxicity. The -amino isomer (18) showed strong apoptosis-inducing effect and exhibited more distinct cytotoxicity than the -isomer.

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“…The most potent HCV protease inhibitory activity was observed on a dimeric compound (24). [7]. It is urgently needed to develop new agents against liver cancer and hepatitis C infection.…”

Section: Hcv Protease Inhibitionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

HCV Protease Inhibitory, Cytotoxic and Apoptosis-Inducing Effects of Oleanolic Acid Derivatives

Hattori

et al. 2009

J Pharm Pharm Sci

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“…The HCV viral enzymes, especially the NS3/4A serine protease and the NS5B RNA-dependent RNA polymerase, offer attractive targets for designing novel viral inhibitors (16,24). Numerous classes of drug molecules targeting these enzymes are currently in various phases of research and development pipelines (15).…”

mentioning

confidence: 99%

Relative Replication Capacity and Selective Advantage Profiles of Protease Inhibitor-Resistant Hepatitis C Virus (HCV) NS3 Protease Mutants in the HCV Genotype 1b Replicon System

King

Kempf

et al. 2008

Antimicrob Agents Chemother

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“…A variety of medicinal herbs were used to treat HCV, especially for patients who are not eligible for IFN/RBV or who fail to respond to IFN [28]. In the United States, milk thistle and glycyrrhizin are the most popular herbal medicines for the treatment of HCV, and they are often used as adjuncts to conventional therapies.…”

Section: Discussionmentioning

confidence: 99%

Triterpenoid Saponins Isolated fromPlatycodon grandiflorumInhibit Hepatitis C Virus Replication

Kim

Park

Lim

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Hepatitis C virus (HCV) infection is a major cause of liver disease, including cirrhosis and hepatocellular carcinoma. Due to significant adverse effects and emergence of resistant strains of currently developed anti-HCV agents, plant extracts have been considered to be potential sources of new bioactive compounds against HCV. The aim of this study was to evaluate the functional effects of triterpenoid saponins contained in the root extract of Platycodon grandiflorum (PG) on viral enzyme activities and replication in both HCV replicon cells and cell culture grown HCV- (HCVcc-) infected cells. Inhibitory activities of triterpenoid saponins from PG were verified by NS5B RNA-dependent RNA polymerase assay and were further confirmed in the context of HCV replication. Six triterpenoid saponins (platycodin D, platycodin D2, platycodin D3, deapioplatycodin D, deapioplatycodin D2, and platyconic acid A), PG saponin mixture (PGSM), were identified as active components exerting anti-HCV activity. Importantly, PGSM exerted synergistic anti-HCV activity in combination with either interferon-α or NS5A inhibitors. We demonstrated that combinatorial treatment of PGSM and IFN-α efficiently suppressed colony formation with significant reduction in drug resistant variant of HCV. These data suggest that triterpenoid saponin may represent a novel anti-HCV therapeutic agent.

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Novel approaches for therapy of chronic hepatitis C

Cited by 20 publications

References 39 publications

HCV Protease Inhibitory, Cytotoxic and Apoptosis-Inducing Effects of Oleanolic Acid Derivatives

HCV Protease Inhibitory, Cytotoxic and Apoptosis-Inducing Effects of Oleanolic Acid Derivatives

Relative Replication Capacity and Selective Advantage Profiles of Protease Inhibitor-Resistant Hepatitis C Virus (HCV) NS3 Protease Mutants in the HCV Genotype 1b Replicon System

Triterpenoid Saponins Isolated fromPlatycodon grandiflorumInhibit Hepatitis C Virus Replication

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