Novel approaches for the design and discovery of quorum-sensing inhibitors

Scutera, Sara; Zucca, Mario; Savoia, Dianella

doi:10.1517/17460441.2014.894974

Cited by 79 publications

(58 citation statements)

References 112 publications

(23 reference statements)

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“…The most recent strategies aimed at discovering new inhibitors that are able to disrupt the different steps of the QS system have focused on targeting signal production, signal molecules, and signal receptors (11) . To overcome the biofi lm formation problem of antibiotic-resistant bacteria, an antipathogenic approach has been recently considered as a viable alternative, and inhibition of QS is a particularly attractive target.…”

Section: Methodsmentioning

confidence: 99%

Antibacterial, anti-swarming and anti-biofilm formation activities of Chamaemelum nobile against Pseudomonas aeruginosa

Kazemian

Ghafourian

Heidari

et al. 2015

Rev. Soc. Bras. Med. Trop.

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Introduction: Chamomile (Chamaemelum nobile) is widely used throughout the world, and has anti-infl ammatory, deodorant, bacteriostatic, antimicrobial, carminative, sedative, antiseptic, anti-catarrhal, and spasmolytic properties. Because of the increasing incidence of drug-resistant bacteria, the development of natural antibacterial sources such as medical herbs for the treatment of infectious diseases is necessary. Extracts from different plant parts such as the leaves, fl owers, fruit, and bark of Combretum albifl orum, Laurus nobilis, and Sonchus oleraceus were found to possess anti-quorum sensing (QS) activities. In this study, we evaluated the effect of C. nobile against Pseudomonas aeruginosa biofi lm formation. Methods: The P. aeruginosa samples were isolated from patients with different types of infection, including wound infection, septicemia, and urinary tract infection. The fl owers of C. nobile were dried and the extract was removed using a rotary device and then dissolved in dimethyl sulfoxide at pH 7.4. The microdilution method was used to evaluate the minimum inhibitory concentration (MIC) of this extract on P. aeruginosa, and biofi lm inhibition was assayed. Results: Eighty percent of the isolated samples (16/20) could form a biofi lm, and most of these were isolated from wound infections. The biofi lm inhibitory concentration of the C. nobile extract was 6.25-25mg/ml, whereas the MIC was 12.5-50mg/ml. Conclusions: The anti-QS property of C. nobile may play an important role in its antibacterial activity, thus offering an additional strategy in the fi ght against bacterial infections. However, molecular investigation is required to explore the exact mechanisms of the antibacterial action and functions of this phytocompound.

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Section: Methodsmentioning

confidence: 99%

Antibacterial, anti-swarming and anti-biofilm formation activities of Chamaemelum nobile against Pseudomonas aeruginosa

Kazemian

Ghafourian

Heidari

et al. 2015

Rev. Soc. Bras. Med. Trop.

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“…Therefore, an alternative strategy, such as quorum-sensing disruption, is one of the most exciting areas in research into multidrug-resistant bacteria [104]. Interestingly, it has been reported that quorum-sensing inhibitors might enhance host immunity by rendering the pathogen avirulent, thus making them incapable of colonizing the host [105].…”

Section: Therapeutic Approachesmentioning

confidence: 99%

“…faecalis , Fsr, and cytolysin quorum-sensing systems (the LuxS system remains under debate) pose a significant medical challenge. To realize a better therapeutic effect, there is a critical need to develop quorum-sensing inhibitors [104]. The three-dimensional structures of quorum-sensing regulating proteins offer molecular-level insights into strategies to treat E .…”

Section: Perspectivesmentioning

confidence: 99%

Molecular Mechanism of Quorum-Sensing in Enterococcus faecalis: Its Role in Virulence and Therapeutic Approaches

Ali

Goraya

Ajmal

et al. 2017

IJMS

121

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Quorum-sensing systems control major virulence determinants in Enterococcus faecalis, which causes nosocomial infections. The E. faecalis quorum-sensing systems include several virulence factors that are regulated by the cytolysin operon, which encodes the cytolysin toxin. In addition, the E. faecalis Fsr regulator system controls the expression of gelatinase, serine protease, and enterocin O16. The cytolysin and Fsr virulence factor systems are linked to enterococcal diseases that affect the health of humans and other host models. Therefore, there is substantial interest in understanding and targeting these regulatory pathways to develop novel therapies for enterococcal infection control. Quorum-sensing inhibitors could be potential therapeutic agents for attenuating the pathogenic effects of E. faecalis. Here, we discuss the regulation of cytolysin, the LuxS system, and the Fsr system, their role in E. faecalis-mediated infections, and possible therapeutic approaches to prevent E. faecalis infection.

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“…According to Defoirdt et al [119], many of the results obtained in experiments that make use of QS signal molecules reporter strains may be questioned, due to the possibility that the tested compounds may be toxic to the reporter strains. Moreover, concerns about the possible emergence of resistance and adverse effects resulting from the alteration of microbiome must be properly addressed in depth [120]. Further research and development is compulsory to examine the suitability and compatibility of quorum quenchers with industrial-scale membrane systems and bioreactors for biofouling control.…”

Section: Do Qs Based Techniques Have Potential To Mitigate Biofouling?mentioning

confidence: 99%

Quorum sensing based membrane biofouling control for water treatment: A review

Siddiqui

Rzechowicz

Winters

et al. 2015

Journal of Water Process Engineering

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Novel approaches for the design and discovery of quorum-sensing inhibitors

Cited by 79 publications

References 112 publications

Antibacterial, anti-swarming and anti-biofilm formation activities of Chamaemelum nobile against Pseudomonas aeruginosa

Antibacterial, anti-swarming and anti-biofilm formation activities of Chamaemelum nobile against Pseudomonas aeruginosa

Molecular Mechanism of Quorum-Sensing in Enterococcus faecalis: Its Role in Virulence and Therapeutic Approaches

Quorum sensing based membrane biofouling control for water treatment: A review

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