Novel approaches for managing aged skin and nonmelanoma skin cancer

Regenerative Wound Dressings for Skin Cancer

“…Retinoids are polyphenolic compounds derived from vitamin A. Among its derivatives, retinol and retinoic acid (Figure 3), also known as tretinoin, are the most commonly used for oral or topical administration to prevent skin cancer [21]. Mechanisms that could be attributed to its anti-tumor effects are based on inhibiting UV-induced phosphorylation of ERK1/2, JNK, and p38 proteins of the and luminosity [108], but also provided protection against UV radiations and UV-induced carcinogenesis by regulating protein activity regarding apoptosis, decreasing reactive oxygen species production, inhibiting tumor incidence and tumorigenesis, and modulating cell cycle molecules and cell signaling pathways [109].…”

“…Retinoids are polyphenolic compounds derived from vitamin A. Among its derivatives, retinol and retinoic acid (Figure 3), also known as tretinoin, are the most commonly used for oral or topical administration to prevent skin cancer [21]. Mechanisms that could be attributed to its anti-tumor effects are based on inhibiting UV-induced phosphorylation of ERK1/2, JNK, and p38 proteins of the Grapes, berries, and red wine [113,114] Pterostilbene and piceatannol, two resveratrol analogs, have also proved anti-cancer activities similar or superior to resveratrol levels [104].…”

“…Generally, the skin plays four fundamental roles, namely body protection against physical, chemical, and bacteriological damages, thermoregulation through skin vasculature and eccrine sweat glands, prevention of dehydration, and conduction of neurosensory information which further contributes to endocrine function and immune surveillance regulations [ 21 , 22 ]. Hence, maintaining its integrity is fundamental.…”

Ultrasound in Sports and Occupational Dermatology

“…Photoaging Chronic exposure to the sun in outdoor sports or ultraviolet light in tanning beds increases the risk of glycosaminoglycan deposits in the upper dermis (papillary dermis), which is called elastosis and has been described on ultrasound imaging by the term "subepidermal low-echogenicity band." [20][21][22] The photodamage of the skin seems to facilitate the development of cutaneous lesions such as actinic keratosis and nonmelanoma skin cancer. 22 On ultrasound imaging, photoaging appears as a hypovascular hypoechoic band in the upper dermis of exposed-to-sun regions such as the face and the dorsum of the forearms, among other corporal regions (Figure 1).…”

“…[20][21][22] The photodamage of the skin seems to facilitate the development of cutaneous lesions such as actinic keratosis and nonmelanoma skin cancer. 22 On ultrasound imaging, photoaging appears as a hypovascular hypoechoic band in the upper dermis of exposed-to-sun regions such as the face and the dorsum of the forearms, among other corporal regions (Figure 1). The subepidermal low-echogenicity band should not be confused with inflammatory or tumoral infiltrations.…”