Abstract:INTRODUCTION:
In the current study, a simple and reliable technique for the synthesis of 2,5-disubstituted 1,3,4-thiadiazoles from ethylbenzimidate and benzothiohydrazides were devised.
METHOD:
This protocol goes via a base-mediated nucleophilic addition elimination process, followed by intramolecular rearrangement
RESULT:
Our method utilizes commonly accessible and non-toxic substrates and a simple workup procedure to produce high to exceptional yields (70-91%) of 2,5-diphenyl 1,3,4-thiadiazoles derivativ… Show more
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