2010
DOI: 10.1021/ac1001178
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Novel Approach for the Separation of Shape-Constrained Isomers with Alternating Copolymer-Grafted Silica in Reversed-Phase Liquid Chromatography

Abstract: This paper describes a novel packing material for high selective reversed-phase high-performance liquid chromatography (RP-HPLC). The organic phase on silica is chemically designed in a way that the weak interaction sites are integrated with high orientation along the polymer main chain and high selectivity can be realized by multiple interactions with solutes. For the above purpose, we synthesized poly(octadecyl acrylate-alt-N-octadecylmaleimide)-grafted silica (Sil-poly(ODA-alt-OMI)) stationary phase. The al… Show more

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Cited by 40 publications
(43 citation statements)
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“…Improvement in approaches used to characterize and design chemically modified surfaces have resulted in increased understanding of stationary-phase morphology, which in turn has permitted development of novel stationary phases with properties tailored for specific applications. Many groups including us have developed various special adsorbents and used in HPLC separation [3][4][5][6][7][8][9][10][11]. However, still the demands of developing new organic phases are necessary for many complex isomer separations.…”
Section: Introductionmentioning
confidence: 99%
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“…Improvement in approaches used to characterize and design chemically modified surfaces have resulted in increased understanding of stationary-phase morphology, which in turn has permitted development of novel stationary phases with properties tailored for specific applications. Many groups including us have developed various special adsorbents and used in HPLC separation [3][4][5][6][7][8][9][10][11]. However, still the demands of developing new organic phases are necessary for many complex isomer separations.…”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, we have been developing polymer or gel forming compound-grafted silica stationary phases based on carbonyl-π interaction mechanism [3,9,10]. Recently, we found that N-substituted maleimide-based alternating copolymer-grafted silica phase showed very good molecular-shape selectivity as well as the enhancement of separation selectivity [10,22,23].…”
Section: Introductionmentioning
confidence: 99%
“…[10] The term "molecular shape selectivity" is commonly used to refer to a chromatographic quality exhibited by certain stationary phases for enhanced separations of geometric isomers, depending on their molecular structure. [11] One successful means to achieve high selectivity for isomers is the use of liquid-crystalline stationary phases. [12] In GC, liquid crystals can be coated directly onto a solid support or capillary wall.…”
Section: Introductionmentioning
confidence: 99%
“…Alternating copolymerization mediated by electron donor-acceptor interactions remains a popular approach for obtaining special materials with different functionalities in a wide range of scientific fields, including nanotechnology [31] and drug delivery [32]. Very recently, we reported the first application of an alternating copolymer, namely poly(ODA-alt-N-octadecylmaleimide (OMI)), grafted on silica for use in HPLC [33]. Here, styrene (ST) (p-electron rich) and N-methylmaleimide (MMI)/OMI (different alkyl chain lengths) monomers were chosen to verify the effect of p-electrons and alkyl chain length on selectivity enhancement in comparison with that of ODA, i.e.…”
Section: Introductionmentioning
confidence: 99%