Novel Application and Serial Evaluation of Tissue-Engineered Portal Vein Grafts in a Murine Model

Maxfield, Mark W.; Stacy, Mitchel R.; Kurobe, Hirotsugu; Tara, Shuhei; Yi, Tai; Cleary, Muriel A.; Zhuang, Zhen W.; Rodríguez-Dávalos, Manuel I.; Emre, Sükrü; Iwakiri, Yasuko; Shinoka, Toshiharu; Breuer, Christopher K.

doi:10.2217/rme-2017-0021

Cited by 4 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, the design of future preclinical studies would better address the clinical relevance, for example, dialysis access ( Gage and Lawson, 2017 ; Ong et al, 2017 ) and meso-Rex bypass ( Maxfield et al, 2017 ), by providing further insight into the mechanisms through experimental designs that are aligned with the purpose and scope of specific clinical applications. In selecting animal models that prematurely terminate adverse remodeling events, the factors that impair vascular regeneration around grafts in clinic may remain largely overlooked.…”

Section: Translation Of Vascular Grafts For Clinics: Success Measuresmentioning

confidence: 99%

Strategies to counteract adverse remodeling of vascular graft: A 3D view of current graft innovations

Tan

Boodagh

Parthiban

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Vascular grafts are widely used for vascular surgeries, to bypass a diseased artery or function as a vascular access for hemodialysis. Bioengineered or tissue-engineered vascular grafts have long been envisioned to take the place of bioinert synthetic grafts and even vein grafts under certain clinical circumstances. However, host responses to a graft device induce adverse remodeling, to varied degrees depending on the graft property and host’s developmental and health conditions. This in turn leads to invention or failure. Herein, we have mapped out the relationship between the design constraints and outcomes for vascular grafts, by analyzing impairment factors involved in the adverse graft remodeling. Strategies to tackle these impairment factors and counteract adverse healing are then summarized by outlining the research landscape of graft innovations in three dimensions—cell technology, scaffold technology and graft translation. Such a comprehensive view of cell and scaffold technological innovations in the translational context may benefit the future advancements in vascular grafts. From this perspective, we conclude the review with recommendations for future design endeavors.

show abstract

Section: Translation Of Vascular Grafts For Clinics: Success Measuresmentioning

confidence: 99%

Strategies to counteract adverse remodeling of vascular graft: A 3D view of current graft innovations

Tan

Boodagh

Parthiban

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

Preclinical In Vivo Assessment of Tissue Engineered Vascular Grafts and Selection of Appropriate Animal Models

Bergmeister¹,

Podesser²

2020

Tissue-Engineered Vascular Grafts

View full text Add to dashboard Cite

Preclinical In-Vivo Assessment of Tissue Engineered Vascular Grafts and Selection of Appropriate Animal Models

Bergmeister

Podesser

2019

Tissue-Engineered Vascular Grafts

View full text Add to dashboard Cite

Novel Application and Serial Evaluation of Tissue-Engineered Portal Vein Grafts in a Murine Model

Abstract: TEVGs are feasible portal vein conduits in a murine model. Further preclinical evaluation of TEVGs may facilitate pediatric clinical translation.

Cited by 4 publications

References 23 publications

Strategies to counteract adverse remodeling of vascular graft: A 3D view of current graft innovations

Strategies to counteract adverse remodeling of vascular graft: A 3D view of current graft innovations

Preclinical In Vivo Assessment of Tissue Engineered Vascular Grafts and Selection of Appropriate Animal Models

Preclinical In-Vivo Assessment of Tissue Engineered Vascular Grafts and Selection of Appropriate Animal Models

Contact Info

Product

Resources

About