Novel antiviral discoveries for Japanese encephalitis virus infections through reporter virus‐based high‐throughput screening
Chunhong Yin,
Peipei Yang,
Qingcui Xiao
et al.
Abstract:Japanese encephalitis (JE) caused by JE virus (JEV), remains a global public health concern. Currently, there is no specific antiviral drug approved for the treatment of JE. While vaccines are available for prevention, they may not cover all at‐risk populations. This underscores the urgent need for prophylaxis and potent anti‐JEV drugs. In this context, a high‐content JEV reporter system expressing Nanoluciferase (Nluc) was developed and utilized for a high‐throughput screening (HTS) of a commercial antiviral … Show more
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