Novel antitumor antibiotics, tetrocarcins.

Tomita, Fusao; Tamaoki, Tatsuya; Shirahata, Kunikatsu; Kasai, Masaji; Morimoto, Makoto; Ohkubo, Shuji; Mineura, Kazuyuki; Ishii, Shinzo

doi:10.7164/antibiotics.33.668

Cited by 96 publications

(57 citation statements)

References 5 publications

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“…The spirotetronate antibiotics comprise of a class of antibacterial and antitumor natural products, such as antlermicin, 13 chlorothricin, 14 kijanimicin, 15 decatromicins, 16 saccharocarcins, 17 tetrocarcins 18 and versipelostatins. 19 A pair of spirotetranate antibiotics lobophorins A (3) and B (4), previously isolated from an alga-associated acintobacterium, were shown to exhibit anti-inflammatory but no antimicrobial activities.…”

Section: Biological Activitymentioning

confidence: 99%

Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127

Niu

Chen

et al. 2011

J Antibiot

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The strain SCSIO 01127, isolated from the South China Sea sediment, was identified as a member of Streptomyces by the 16S rDNA sequence analysis. Two new spirotetronate antibiotics lobophorins E (1) and F (2), along with two known analogs lobophorins A (3) and B (4), were isolated from Streptomyces sp. SCSIO 01127. Their structures were elucidated on the basis of detailed IR, NMR and MS spectroscopic analyses. The new compound lobophorin F (2) showed antibacterial activities against Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 with MIC values of 8 mg ml À1 for both the strains, better than that of lobophorin B (4). Lobophorin F (2) also displayed better cytotoxic activities than lobophorin B (4), with IC 50 of 6.82, 2.93 and 3.16 mM against SF-268, MCF-7 and NCI-H460, respectively.

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Section: Biological Activitymentioning

confidence: 99%

Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127

Niu

Chen

et al. 2011

J Antibiot

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“…Das Tetronsäuremotiv der B-Ringe lässt auf eine Verwandtschaft zu Antibiotika des TetrocarcinTyps schließen. [9] Weitere strukturelle Charakteristika aller drei Verbindungen sind die zwei Methylgruppen (C(18), C(19)) der jeweiligen A-Ringe und das Oxabicyclooctansystem (Ringe C und D).…”

Section: Günther Jung Und Louis Moroder Gewidmetunclassified

Abyssomicin C – ein polycyclisches Antibiotikum aus einem marinen Verrucosispora‐Stamm als Inhibitor für die p‐Aminobenzoesäure/Tetrahydrofolat‐Biosynthese

et al. 2004

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Aus der Tiefe: Der Biosyntheseweg von p‐Aminobenzoesäure bietet mehrere Angriffspunkte zur Bekämpfung pathogener Mikroorganismen. Abyssomicin C (siehe Formel) ist ein neues Antibiotikum, das die Biosyntheseschritte zwischen Chorisminsäure und p‐Aminobenzoesäure hemmt. Die antibiotische Aktivität beruht möglicherweise auf einer irreversiblen Enzyminaktivierung, die durch eine Michael‐Addition vermittelt wird.

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“…Nakashima et al (2000) reported that a natural product Tetrocarcin A inhibited mitochondrial functions of Bcl-2 and suppressed its anti-apoptotic activity ( Figure 3a). Tetrocarcins were originally discovered from random screening to have antibacterial activity against Gram-positive bacteria and antitumor activity against experimental murine tumors (Tomita et al, 1980). In the recent study by Nakashima et al (2000), the screening of a library of natural products using cells overexpressing Bcl-2 or Bcl-x L led to the identi®cation of Tetrocarcin A.…”

Section: Cell Permeable Bh3 Peptides That Induce Apoptosis In Intact mentioning

confidence: 99%

Bcl-2 family proteins as targets for anticancer drug design

2000

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Novel antitumor antibiotics, tetrocarcins.

Cited by 96 publications

References 5 publications

Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127

Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127

Abyssomicin C – ein polycyclisches Antibiotikum aus einem marinen Verrucosispora‐Stamm als Inhibitor für die p‐Aminobenzoesäure/Tetrahydrofolat‐Biosynthese

Bcl-2 family proteins as targets for anticancer drug design

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