Novel antitumor activity of the combined treatment of galloylquinic acid compounds with doxorubicin in solid Ehrlich carcinoma model via the Notch signaling pathway modulation

Novel Preclinical Study of Galloylquinic Acid Compounds from Copaifera lucens with Potent Antifungal Activity against Vaginal Candidiasis Induced in a Murine Model via Multitarget Modes of Action

“…Another study stated that C. glabrata was susceptible to the leaf extract of Camellia sinensis , which is rich in polyphenolic compounds ( 20 ). Other studies mentioned that plant polyphenol-rich extracts had potential activity against pathogenic fungi ( 21 , 22 ), consistent with the polyphenolic properties of GQAs, which are capable of reducing reactive oxygen species due to their promising antioxidant properties ( 16 , 17 ). Additionally, our tested compounds showed a wider safe window in an MTT cytotoxicity assay using Vero cells, with an IC 50 of 168.17 mg/mL.…”

“…A voucher sample was kept (RB 474303) as a reference at the Laboratory of Pharmacognosy, FCFRP, Brazil. The major galloylquinic acid compounds (GQAs) were extracted and identified spectrophotometrically in the n -butanolic fraction of C. lucens , using high-performance liquid chromatography (HPLC), based on their characteristic UV spectra according to our previously reported data ( 16 , 17 ). The compounds were prepared as a stock solution (50 mg/mL) in dimethyl sulfoxide (DMSO) and stored at −80°C until use.…”

“…Phytochemical investigations revealed the presence of a high content of galloylquinic acid compounds (GQAs), representing the major secondary metabolites in the n -butanolic and aqueous fractions of the leaf extract, which are mainly responsible for their bioactivity. In a recent study by our group, GQAs also exhibited promising antitumor activity in the Ehrlich solid tumor model, due to the polyphenolic nature of this class of compounds, which significantly inhibited oxidative stress ( 17 ). Here, we report the use of GQAs from C. lucens leaves as safe and potent antifungal agents for the treatment of vaginal candidiasis.…”

Comprehensive Metabolite Fingerprinting of Australian Black and Green Olives and Their Antioxidant and Pharmacokinetics Properties

“…Alkhalidy et al [28] found that it can boost the synthesis of adiponectin, a hormone involved in controlling blood sugar levels and fatty acid breakdown, which suggests a potential role in managing obesity and diabetes [28]. Another study found that galloyl quinic acid can inhibit the growth of human colon cancer cells and may have potential as an anti-cancer agent [29].…”

Koetjapic acid: unveiling its potential as a saviour in the realm of biological and medicinal properties, with a focus on anticancer mechanism of action

“…A recent study demonstrated that a naturally occurring compound galloylquinic acid suppressed the expression of VEGF and induced cytotoxicity in MCF-7 breast cancer cells [ 37 ]. Moreover, a study also revealed that galloylquinic acid along with doxorubicin, a chemotherapeutic agent, downregulated various oncogenic pathways by remarkably reducing the levels of Notch-1, VEGF, TNF-α, IL-6, cyclin D1, and NFkB, while increasing the activity of capsase-3 in tumour tissues [ 38 ]. Other natural compounds such as curcumin, triterpenoids, celastrol, tocotrienols have shown promising tendency to inhibit angiogenesis promoting proteins such as VEGF/VEGFR, FGF/FGFR, HIF.…”