Novel antimicrobial secondary metabolites from a Penicillium sp. isolated from Brazilian cerrado soil

Abstract

The morphological features of a Penicillium, isolated from Brazilian cerrado soil, were characterized and showed to be distinctly different from all well-defined Penicillium species. Chemical and biological investigation on the ethyl acetate extract of this Penicillium isolate resulted in the isolation of three new naphthalenoids: a major metabolite, methyl 6-acetyl-4-*Corresponding author methoxy-5, 7, 8-trihydroxynaphthalene-2-carboxylate and two minor ones, methyl 6-acetyl-4-methoxy-7,8 dihydroxynaphthalene-2-carboxylate and methyl 6 acetyl-4-methoxy-5, 8-dihydroxynaphthalene-2 carboxylate. Their structures were determined based on their mono and bidimensional nuclear magnetic resonance data. Acetyl, allyl and methoxyl derivatives of

Antimicrobial Potential of Endophytic Fungi Derived from Three Seagrass Species: Cymodocea serrulata, Halophila ovalis and Thalassia hemprichii

“…have been most studied in the bioperspective program since the discovery of penicillin. They produce various kinds of secondary metabolites including antibacterial [39,40] and antifungal substances [41–43]. Most of those reported isolates were from soils.…”

Antimicrobial activities of culturable microorganisms (actinomycetes and fungi) isolated from Chaabe Cave, Algeria

“…A large number of fungal extracts and/or extracellular products have been found to have antimicrobial activity, mainly from species of the ubiquitous genus Penicillium (Rancic et al, 2006;Petit et al, 2009). A total of 23 strains of Penicillium were selected for screening of antimicrobial activity against pathogenic microorganisms.…”

Pretrichodermamide C and N-methylpretrichodermamide B, two new cytotoxic epidithiodiketopiperazines from hyper saline lake derived Penicillium sp.

“…The genus Penicillium comprises more than 300 known species (Kirk et al, 2008) and contains a highly diversified array of active compounds. Thousands of Penicillium isolates have probably already been screened in bioprospecting programmes since the discovery of penicillin, and still new biologically active secondary metabolites continue to be discovered from these fungi indicating their importance as a source for novel bioactive molecules with interest to the pharmaceutical industry (Petit et al, 2009).…”