Novel anticancer agents from plant sources

Shah, Unnati; Shah, Ripal; Acharya, Sanjeev; Acharya, Niyati

doi:10.1016/s1875-5364(13)60002-3

Cited by 65 publications

(46 citation statements)

References 27 publications

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“…125 Vinca alkaloids (vinblastine and vincristine) are obtained from the Madagascar periwinkle, Catharanthus roseus (Apocynaceae), and were the first plant source used clinically as anticancer agents for leukemias, lymphomas, breast, testicular, and lung cancers, and Kaposi's sarcoma. 126 In recent years, semisynthetic derivatives of vinca alkaloids, such as vindesine and vinorelbine, have received approval from the US Food and Drug Administration, and vinflunine has been approved by the European Medicines Agency as a second-line chemotherapeutic agent in the treatment of metastatic urothelial cancer. 127 Moreover, vinflunine and vinorelbine have shown minimized toxicity in comparative animal models.…”

Section: Application Of Cpp/ttp Nanocarriers For Herb-based Anticancementioning

confidence: 99%

“…The two semisynthetic derivatives of podophyllotoxin that are used in the treatment of lymphomas and bronchial and testicular cancers are etoposide and teniposide. 126 Homoharringtonine and elliptinium are the other herb-derived agents in clinical use. Homoharringtonine was originally derived from the Chinese plant Cephalotaxus harringtonia var.…”

Section: Application Of Cpp/ttp Nanocarriers For Herb-based Anticancementioning

confidence: 99%

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Tumor-targeting delivery of herb-based drugs with cell-penetrating/tumor-targeting peptide-modified nanocarriers

Kebebe¹,

Liu²,

Wu³

et al. 2018

IJN

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Cancer has become one of the leading causes of mortality globally. The major challenges of conventional cancer therapy are the failure of most chemotherapeutic agents to accumulate selectively in tumor cells and their severe systemic side effects. In the past three decades, a number of drug delivery approaches have been discovered to overwhelm the obstacles. Among these, nanocarriers have gained much attention for their excellent and efficient drug delivery systems to improve specific tissue/organ/cell targeting. In order to enhance targeting efficiency further and reduce limitations of nanocarriers, nanoparticle surfaces are functionalized with different ligands. Several kinds of ligand-modified nanomedicines have been reported. Cell-penetrating peptides (CPPs) are promising ligands, attracting the attention of researchers due to their efficiency to transport bioactive molecules intracellularly. However, their lack of specificity and in vivo degradation led to the development of newer types of CPP. Currently, activable CPP and tumor-targeting peptide (TTP)-modified nanocarriers have shown dramatically superior cellular specific uptake, cytotoxicity, and tumor growth inhibition. In this review, we discuss recent advances in tumor-targeting strategies using CPPs and their limitations in tumor delivery systems. Special emphasis is given to activable CPPs and TTPs. Finally, we address the application of CPPs and/or TTPs in the delivery of plant-derived chemotherapeutic agents.

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Section: Application Of Cpp/ttp Nanocarriers For Herb-based Anticancementioning

confidence: 99%

Section: Application Of Cpp/ttp Nanocarriers For Herb-based Anticancementioning

confidence: 99%

Tumor-targeting delivery of herb-based drugs with cell-penetrating/tumor-targeting peptide-modified nanocarriers

Kebebe¹,

Liu²,

Wu³

et al. 2018

IJN

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“…[30,31] Capsicum annuum C. annuum is widely used as vegetables and food colorants which are a good source of carotenoid pigments. [32,33] The red carotenoids in paprika (C. annuum L.) are mainly capsanthin, capsorubin, and capsanthin 3,6-epoxide in which capsanthin and capsorubin have been reported to show antioxidative activities. [34,35] Mesua ferrea M. ferrea known as "Nagakesara" [36] reported for antioxidant, [37,38] hepatoprotective, [39] analgesic, [40] antimicrobial, [41] antivenom, [42] anticancer, [43] antiulcer, [44] anti-inflammatory, [45] antiasthmatic, [46] and other several activities.…”

Section: Tinospora Cordifoliamentioning

confidence: 99%

Untitled

Amrish¹

2018

AJP

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Cancer is a disease in which abnormal cells proliferate in the body. It is a group of various diseases involving uncontrolled multiplication and division of abnormal cells in the body. These abnormal cells form malignant growths which called neoplasm. Nowadays, cancer considered as one of the most prevalent diseases in the world, and its mortality is increasing. It is necessary to investigate new strategies to prevent and treat disease. Herbal medicines block critical biochemical pathways converting normal cells to cancer cells for treatment. Herbal medicines block signal transduction in cancer which is a primary channel, by such as controlling nuclear factor-kB signaling pathway, protein tyrosine kinase pathway, and mitogen-activated protein kinases signal pathways. The various study reported that people with cancer commonly use herbal products because of no side effects on healthy cells. Herbal medicine is one of the most widely used alternative therapies by people with cancer. Clinically proven herbal remedies help to prevent or relieve the symptoms of cancer or treatment side effects by a conventional method. We have discussed various medicinal herbs found in India which have the potential to be used in cancer therapy. This present review will focus on the different medicinal plants containing chemical constituents used in the treatment of cancer with their possible mechanism of action.

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“…Presently, there are two CPT derivatives in clinical use, topotecan (Hycamptin) and irinotecan (Camptosar). These analogues have been found to be significantly active compared to other known CPT analogues, but then again, they are not as effective as some other cytotoxic compounds, and their side effects, such as high toxicity, discourage their usage . Hence, these problems with the inhibition of Top1 poisons for treating human cancer have led to the use of alternative and novel ideas, improving the activity of CPT by utilizing computational drug design techniques to enhance its Top1 poison property.…”

Section: Introductionmentioning

confidence: 99%

Molecular docking study and structure‐based design of novel camptothecin analogues used as topoisomerase I inhibitor

Arthur

Uzairu

2018

J Chinese Chemical Soc

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The paper describes the molecular docking study of the inhibition of human topoisomerase I (Top1), which is the molecular target of a diverse set of anticancer compounds such as glycinate, camptothecin, and its analogues. The reaction mechanisms involving their interaction with a transient Top1–DNA covalent complex inhibits the resealing of a single‐strand nick created by the enzyme to relieve superhelical tension in duplex DNA; this was confirmed using ICM‐Pro Molsoft program. Our research findings on this reaction indicate that its planner nature, the presence of some fragments on the lactone E‐ring, and the Pi–Pi interactions of the camptothecin drugs with DNA were directly responsible for its stable ternary complex with Top1. The molecular docking result of our study demonstrates that morpholinodoxorubicin (−32.835 kcal/mol), 9‐amino‐20‐RS‐camptothecin (−28.792 kcal), and camptothecin lysinate HCl (−28.224 kcal) best inhibit Top1 when compared with other National Service Center (NSC) compounds within our dataset. These compounds were further utilized in designing new potent antitumor compounds by attaching potent fragments to the lactone ring of the compounds. Most of these compounds were reported to be more active than the parent structure, some of which includes CLD‐12, CLD‐7, and CD‐9 with a binding affinity of −40.307, −36.743, and − 36.072 kcal/mol, respectively.

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Novel anticancer agents from plant sources

Cited by 65 publications

References 27 publications

Tumor-targeting delivery of herb-based drugs with cell-penetrating/tumor-targeting peptide-modified nanocarriers

Tumor-targeting delivery of herb-based drugs with cell-penetrating/tumor-targeting peptide-modified nanocarriers

Untitled

Molecular docking study and structure‐based design of novel camptothecin analogues used as topoisomerase I inhibitor

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