Novel Antibacterial Agents: An Emergent Need to Win the Battle Against Infections

Simões, Natércia Guerra; Bettencourt, Ana; Monge, Nuno; Ribeiro, Isabel

doi:10.2174/1389557516666160907151454

Cited by 29 publications

(17 citation statements)

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“…Instead of developing new antibiotics that address novel targets, current approaches focus on structural modifications of well-established antibiotics such as vancomycin to restore their impact on resistant bacteria. Various further strategies to combat lifethreatening bacterial infections, such as the use of bacteriophages (Matsuzaki et al 2005), monoclonal antibodies (Lorenz et al 2000;Motley et al 2019), antimicrobial peptides (Fox 2013), metallic and polymeric nanoparticles (Beyth et al 2015), and quorum-sensing inhibitors (Rasmussen and Givskov 2006), among others, are under extensive investigation (Simões et al 2017). However, despite partially suggesting promising potential as effective alternative antimicrobials, to date, none of these novel strategies have found significant broad application.…”

Section: Antibiotic Resistance -An Emerging Problemmentioning

confidence: 99%

Renaissance of vancomycin: approaches for breaking antibiotic resistance in multidrug-resistant bacteria

et al. 2020

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The emergence of multidrug-resistant bacteria demands innovations in the development of new antibiotics. For decades, the glycopeptide antibiotic vancomycin has been considered as the “last resort” treatment of severe infections caused by Gram-positive bacteria. Since the discovery of the first vancomycin-resistant enterococci strains in the late 1980s, the number of resistances has been steadily rising, with often life-threatening consequences. As an alternative to the generation of completely new substances, novel approaches focus on structural modifications of established antibiotics such as vancomycin to overcome these resistances. Here, we provide an overview of several promising modifications of vancomycin to restore its efficacy against vancomycin-resistant enterococci.

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Section: Antibiotic Resistance -An Emerging Problemmentioning

confidence: 99%

Renaissance of vancomycin: approaches for breaking antibiotic resistance in multidrug-resistant bacteria

et al. 2020

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“…), are frequently isolated in hospital environments, where they are responsible for the majority of nosocomial infections [5]. In particular, Gram-positive bacteria have predominantly developed resistance to all the available antibiotics and pose a serious problem not only in hospitals but also for the general population [6,7]. Infections of methicillin-resistant Staphylococcus aureus (MRSA) are of particular concern [8].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity and Molecular Docking Studies of a Selected Series of Hydroxy-3-arylcoumarins

et al. 2019

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Antibiotic resistance is one of the main public health concerns of this century. This resistance is also associated with oxidative stress, which could contribute to the selection of resistant bacterial strains. Bearing this in mind, and considering that flavonoid compounds are well known for displaying both activities, we investigated a series of hydroxy-3-arylcoumarins with structural features of flavonoids for their antibacterial activity against different bacterial strains. Active compounds showed selectivity against the studied Gram-positive bacteria compared to Gram-negative bacteria. 5,7-Dihydroxy-3-phenylcoumarin (compound 8) displayed the best antibacterial activity against Staphylococcus aureus and Bacillus cereus with minimum inhibitory concentrations (MICs) of 11 g/mL, followed by Staphylococcus aureus (MRSA strain) and Listeria monocytogenes with MICs of 22 and 44 g/mL, respectively. Moreover, molecular docking studies performed on the most active compounds against Staphylococcus aureus tyrosyl-tRNA synthetase and topoisomerase II DNA gyrase revealed the potential binding mode of the ligands to the site of the appropriate targets. Preliminary structure–activity relationship studies showed that the antibacterial activity can be modulated by the presence of the 3-phenyl ring and by the position of the hydroxyl groups at the coumarin scaffold.

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“…Such scenario has increased the demand to explore new innovative strategies in antimicrobial therapies (Kruijshaar et al, 2008;Arias and Murray, 2009;Harms et al, 2016). Up to date, several innovative approaches that are currently under investigation are antimicrobial peptides, therapeutic antibodies, phage therapy, and antimicrobial NPs (Simoes et al, 2017). Recently, MNPs based strategies have been developed to treat infections caused by multi-drug resistant bacteria as well as bacteria-related biofilm (Reddy et al, 2012;Bohara and Pawar, 2015;Zazo et al, 2016;Häffner and Malmsten, 2017;Majid et al, 2018).…”

Section: Bacterial Theranosticsmentioning

confidence: 99%

Review on Recent Progress in Magnetic Nanoparticles: Synthesis, Characterization, and Diverse Applications

et al. 2021

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Diverse applications of nanoparticles (NPs) have revolutionized various sectors in society. In the recent decade, particularly magnetic nanoparticles (MNPs) have gained enormous interest owing to their applications in specialized areas such as medicine, cancer theranostics, biosensing, catalysis, agriculture, and the environment. Controlled surface engineering for the design of multi-functional MNPs is vital for achieving desired application. The MNPs have demonstrated great efficacy as thermoelectric materials, imaging agents, drug delivery vehicles, and biosensors. In the present review, first we have briefly discussed main synthetic methods of MNPs, followed by their characterizations and composition. Then we have discussed the potential applications of MNPs in different with representative examples. At the end, we gave an overview on the current challenges and future prospects of MNPs. This comprehensive review not only provides the mechanistic insight into the synthesis, functionalization, and application of MNPs but also outlines the limits and potential prospects.

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Novel Antibacterial Agents: An Emergent Need to Win the Battle Against Infections

Abstract: Several advances have been made but a great effort is still mandatory in order to reach feasible, effective and marketable novel antimicrobial products.

Cited by 29 publications

References 0 publications

Renaissance of vancomycin: approaches for breaking antibiotic resistance in multidrug-resistant bacteria

Renaissance of vancomycin: approaches for breaking antibiotic resistance in multidrug-resistant bacteria

Antibacterial Activity and Molecular Docking Studies of a Selected Series of Hydroxy-3-arylcoumarins

Review on Recent Progress in Magnetic Nanoparticles: Synthesis, Characterization, and Diverse Applications

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