Novel antiallergic and antiinflammatory agents. Part I: Synthesis and pharmacology of glycolic amide derivatives

Enantioselective Synthesis of β‐Amino Esters Bearing a Benzothiazole Moiety via a Mannich‐Type Reaction Catalyzed by a Cinchona Alkaloid Derivative

“…[3] On the other hand, benzothiazole derivatives have been studied extensively and found to have a broad spectrum of biological activities which include antiviral, [4] antiallergic, [5] antimicrobial, [6] and anticancer. [7] So, based on our technical competence in the field of plant virology, [1d] we prepared herein a series of novel asymmetric β-amino esters incorporating a benzothiazole moiety to obtain potent environmentally friendly antiviral agents for plants.…”

Synthesis and mutagenicity of 2-aryl-substitute (o-hydroxy-, m-bromo-, o-methoxy-, o-nitro-phenyl or 4-pyridyl) benzothiazole derivatives on Salmonella typhimurium and human lymphocytes exposed in vitro

“…Antifungal (Ryu et al 2003), anti-bacterial (Turan-Zitouni et al 2003, anti-inflammatory and anti-allergic (Ban et al 1998) activities have also been reported for several BT derivatives. A series of phenyl BT compounds synthesized as prodrugs were tested for their antitumor activities and selected for clinical evaluation (Hall et al 1999;Bradshaw & Westwell 2004;Westwell 2004).…”

Hybrid benzothiazole analogs as antiurease agent: Synthesis and molecular docking studies

“…Benzothiazole is a neuroprotective agent [7,8], muscarinic receptor [9], Lck enzyme inhibitor [10], anti-bacterial [11] anti-allergic agents [12], antiglycation [13], antilieshmanial, [14] and β-glucuronidase [15].…”