Novel anti-angiogenic effects of aromatic-turmerone, essential oil isolated from spice turmeric

Yue, Grace Gar-Lee; Kwok, Hin‐Fai; Lee, Julia Kin-Ming; Jiang, Lei; Chan, K. C. Allen; Cheng, Ling; Wong, Eric C.; Leung, Ping‐Chung; Fung, Kwok‐Pui; Lau, Clara Bik‐San

doi:10.1016/j.jff.2015.03.030

Cited by 35 publications

(29 citation statements)

References 32 publications

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“…It significantly inhibited the blood vessel growth, confirmed by the in vivo studies using Matrigel plugs mouse model. Ar-turmerone can be used as a potential anti-angiogenic agent 78 . Yue et al 79 also demonstrated the enhancement of antiproliferative and anti-angiogenic activities of CUR in the presence of turmerones in human colon cancer cells and endothelial cells respectively.…”

Section: Biological Activities Of Curcuminoidsmentioning

confidence: 99%

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Amalraj¹,

Pius

Gopi

et al. 2017

Journal of Traditional and Complementary Medicine

708

413

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In recent years, several drugs have been developed deriving from traditional products and current drug research is actively investigating the possible therapeutic roles of many Ayruvedic and Traditional Indian medicinal therapies. Among those being investigated is Turmeric. Its most important active ingredient is curcuminoids. Curcuminoids are phenolic compounds commonly used as a spice, pigment and additive also utilized as a therapeutic agent used in several foods. Comprehensive research over the last century has revealed several important functions of curcuminoids. Various preclinical cell culture and animals studies suggest that curcuminoids have extensive biological activity as an antioxidant, neuroprotective, antitumor, anti-inflammatory, anti-acidogenic, radioprotective and arthritis. Different clinical trials also suggest a potential therapeutic role for curcuminoids in numerous chronic diseases such as colon cancer, lung cancer, breast cancer, inflammatory bowel diseases. The aim of this review is to summarize the chemistry, analog, metal complex, formulations of curcuminoids and their biological activities.

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Section: Biological Activities Of Curcuminoidsmentioning

confidence: 99%

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Amalraj¹,

Pius

Gopi

et al. 2017

Journal of Traditional and Complementary Medicine

708

413

View full text Add to dashboard Cite

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“…EOs have different functional characteristics such as antioxidant, antidepressant-like, anti-angiogenic, and antidiabetic activities. [2][3][4] Together with these features, some EOs have shown strong antimicrobial activity that can be exploited against food pathogens. There are few studies on the effect of EOs on probiotic strains, [5] and considering that they both are used in combination for functional products, it is important to investigate the effect of EOs on probiotics.…”

Section: Introductionmentioning

confidence: 99%

Essential oils from three species of Mentha harvested in Sardinia: chemical characterization and evaluation of their biological activity

Fancello

Zara

Petretto

et al. 2017

International Journal of Food Properties

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The chemical composition, antimicrobial activity, and antioxidant activity of Mentha (M.) requienii, M. pulegium L., and M. aquatica (L.) Huds from Sardinia, Italy, were tested. The chemical composition was determined by Gas Chromatography-Mass Spectrometry (GC-MS) and GC-Flame Ionization Detector (GC-FID) analyses. The antiradical activity was assessed by 2,2-Diphenyl-1-picrylhydrazyl and antioxidant capacity assay (ABTS) assay and minimal inhibition concentration was determined by microdilution broth analysis. The major components found in M. requienii EO were pulegone, menthone, and limonene; similarly, the major components of M. pulegium EO were pulegone and iso-menthone. By contrast, the major components of the essential oil (EO) from M. aquatica are terpinyl acetate and eucalyptol. The antioxidant activity of M. aquatica EO was higher than that of M. requienii and M. pulegium. The EO from M. requienii had good antifungal and antioxidant activities. In the concentration range tested, the mint EOs did not show any antibacterial activity against Staphylococcus aureus 20231 Deutsche SammLung von Mikroorganismen und Zellkulturen (DSMZ), Salmonella enterica subsp. bongori serovar 66:z41:-13772 DSMZ, and four strains of Listeria monocytogenes. Lactic acid bacteria (LAB) strains were not inhibited by the EOs tested, with the exception of Lactobacillus brevis, which showed slight sensitivity to M. pulegium and M. requenii EOs. Yeast strains were in general sensitive to the different Mentha EOs tested and were species and strain dependent.

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“…Nevertheless, searching for new antiangiogenic agents, especially from natural source including herbal medicines, draws preclinical researchers’ interest. Some chemopreventive molecules isolated from natural products, including taxol 37 , curcumin 38 , deoxybouvardin 39 , and aromatic-turmerone 40 are also demonstrated to inhibit angiogenesis in preclinical models. Being reported as an anti-tumor natural compound, actein has not been studied for its activity on angiogenesis and in breast tumor-bearing animal models.…”

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confidence: 99%

New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment

Yue

Xie

Lee

et al. 2016

Sci Rep

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Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida (Chinese herb “shengma”) which could inhibit the growth of breast cancer cells. Nevertheless, the effect of actein on angiogenesis, which is an essential step for tumor growth and metastasis, has never been reported. Hence, this study aimed to investigate the in vitro and in vivo effects of actein on angiogenesis using human microvascular endothelial cells (HMEC-1), matrigel plug and tumor-bearing mouse models. Our results showed that actein significantly inhibited the proliferation, reduced the migration and motility of endothelial cells, and it could suppress the protein expressions of VEGFR1, pJNK and pERK, suggesting that JNK/ERK pathways were involved. In vivo results showed that oral administration of actein at 10 mg/kg for 7 days inhibited blood vessel formation in the growth factor-containing matrigel plugs. Oral actein treatments (10–15 mg/kg) for 28 days resulted in decreasing mouse 4T1 breast tumor sizes and metastasis to lungs and livers. The apparent reduced angiogenic proteins (CD34 and Factor VIII) expressions and down-regulated metastasis-related VEGFR1 and CXCR4 gene expressions were observed in breast tumors. Our novel findings provide insights into the use of actein for development of anti-angiogenic agents for breast cancer.

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Novel anti-angiogenic effects of aromatic-turmerone, essential oil isolated from spice turmeric

Cited by 35 publications

References 32 publications

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Essential oils from three species of Mentha harvested in Sardinia: chemical characterization and evaluation of their biological activity

New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment

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