Novel anti-aging herbal formulation Jing Si displays pleiotropic effects against aging associated disorders

Clinical course of patients with severe SARS-CoV-2 infection co-treatment with Jin Si Herbal Tea in Eastern Taiwan: A retrospective cohort study

“…NRICM101 is composed of 8 Chinese herbs. The authors study using co-treatment of Jing Si Herbal Tea is composed of 8 Chinese herbs different from NRICM101 ( Hsieh et al, 2022 , Shibu et al, 2022 ). In the preliminary pharmaceutical study, Jing Si Herbal Tea decreased spike protein and ACE2 interaction, 3CL protease activity, and TRPMSS2 protease activity ( Kwon et al, 2020 , Lau et al, 2008 , Mahendra et al, 2021 , Shibu et al, 2022 , Tang et al, 2021 ).…”

“…Despite the above TCM formula, another Chinese medicine herbal-based preparation Jin Si Herbal Tea was formulated to add the therapy for mild to moderate COVID-19 patients ( Hsieh et al, 2022 ). The constituents of Jin Si Herbal Tea have shown promising evidence for antiviral effects and protection against comorbidities that forms the rationale for the antiviral preparation ( Shibu et al, 2022 ). The constituents of Jin Si Herbal Tea include leaves of Artemisia argyi, Ohwia caudate, Ophiopogon japonicas, and Perilla frutescens; Roots of Houttuynia cordata, Platycodon grandifloras, and Glycyrrhiza uralensis; and flowers of Chrysanthemum × morifolium ( de Almeida-Pititto et al, 2020 , Kim et al, 2021 , Kwon et al, 2020 , Liu et al, 2020 , Mahrosh and Mustafa, 2021 , Tang et al, 2021 , Zhang et al, 2016 ).…”

Artemisia argyi exhibits anti-aging effects through decreasing the senescence in aging stem cells

“…From previous reports, it was evident that research conducted using Artemisia argyi was focused mainly on active polysaccharides, volatile oil, flavonoids and other active ingredient. Also, previously we have reported a decoction containing 8 herbs including A. argyi showed pleiotropic effect against various age-related diseases [ 40 ]. However, research that mainly focus on the therapeutic properties of the crude water extract of A. argyi is rare, so it opens a new scope for basic researchers to explore its health benefits in aging and maintenance of a healthy life.…”

Chinese herbal prescriptions for COVID-19 management: Special reference to Taiwan Chingguan Yihau (NRICM101)

“…A.DC.). Clinical evidence continues to grow in support of JSHD as an adjuvant treatment in COVID-19 infection ( Shibu et al, 2022 ). The therapeutic efficacy of JSHD in COVID-19 infection is supported by antiviral activity (blocks ACE2, TMPRSS2 and 3CLpro activities), antioxidative (increases SOD activity) and anti-inflammatory activities (decreases iNOS expression and NF-κB phosphorylation; inhibits the production of NO, TNF-α and IL-6), the ability to suppress immune system overactivation (by reducing macrophages, neutrophils, and white blood cells), and attenuate organ injuries ( Lu et al, 2021 ).…”