Novel anti-adherence activity of mulberry leaves: inhibition of Streptococcus mutans biofilm by 1-deoxynojirimycin isolated from Morus alba

Abstract

The purified compound of M. alba showed an 8-fold greater reduction of MIC against S. mutans than the crude extract (MICs, 15.6 and 125 mg/L, respectively). The extract strongly inhibited biofilm formation of S. mutans at its active accumulation and plateau phases. The purified compound led to a 22% greater reduction in alkali-soluble polysaccharide than in water-soluble polysaccharide. The purified compound was found to be 1-deoxynojirimycin (DNJ). Confocal microscopy revealed that DNJ distorts the biofilm architecture of S. mutans. CONCLUSIONS The whole study reflects a prospective role of DNJ as a therapeutic agent by controlling the overgrowth and biofilm formation of S. mutans.

Activity of solvent extracts of Prosopis spicigera, Zingiber officinale and Trachyspermum ammi against multidrug resistant bacterial and fungal strains

“…There exists vast literature on the antiviral, anticariogenic, anthemintic, antibacterial, antifungal, anti-inflammatory and antimolluscal properties of different plants parts [13][14][15][16][17]. Their uses as remedies for many infectious diseases as well as searches for additional substances in plants with antimicrobial activity are frequent [18].…”

Antimicrobial Activity in vitro of Aqueous Extracts of Oregano (Origanum vulgare L.) and Thyme (Thymus vulgaris L.)

“…There are a number of data about inhibitory action of water, alcohol and other extracts of various herbs on the development of pathogens, giving rise to hopes for efficient use of plant extracts in a variety of infections (Islam et al, 2008;Pichardo et al, 2013;Shahnama et al, 2015;Sarbadhikary et al, 2015). For example, studies of Tabassum et al, (2013) (Gopinath and Prakash, 2013).…”

Phytochemical screening and antimicrobial activity of selected medicinal plant species

“…Alkaloids are also important secondary chemical which play a vital role as anesthetic agent. Alkaloids also create variation in physiology [13]. Phenol and its compound are distributed in many plants, phenolic compound are used for the treatment of many disorder and also due to its toxic action prevent the growth of many pathogens [14].…”