Novel Anionophores for Biosensor Applications: Nano Characterisation of SAMs Based on Amphiphilic Imidazolium Protophanes and Cyclophanes on Gold Surfaces

Sporer, Christian; Casal, Lucia; Caballero, David; Samitier, J.; Errachid, Abdelhamid; Pérez-García, Lluïsa

doi:10.1166/sl.2009.1144

Cited by 3 publications

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“…For instance, our preliminary studies 17 indicated that some bis-imidazolium salts with sulfur atoms in their alkyl chains self-organize, forming monolayers on gold surfaces, where we have also explored the anion recognition phenomenon. 18 On the other hand, ionogels containing imidazolium ibuprofenate have been shown to be an efficient drug releasing system with kinetics controlled by the nature of the silica wall. 19 In this context, we aimed to prepare gold nanoparticles coated with bis-imidazolium amphiphiles, to explore their ability toward anion recognition, and their potential use in nanomedicine.…”

Section: ' Introductionmentioning

confidence: 99%

“…As a step forward in this research we have focused our attention on the use of imidazolium based gemini amphiphiles, regarded as potential anion sensors and anion deliverers, to explore the ionophoric behavior of these imidazolium scaffolds both on surfaces and in the solid state. For instance, our preliminary studies indicated that some bis-imidazolium salts with sulfur atoms in their alkyl chains self-organize, forming monolayers on gold surfaces, where we have also explored the anion recognition phenomenon . On the other hand, ionogels containing imidazolium ibuprofenate have been shown to be an efficient drug releasing system with kinetics controlled by the nature of the silica wall …”

Section: Introductionmentioning

confidence: 99%

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Gemini Imidazolium Amphiphiles for the Synthesis, Stabilization, and Drug Delivery from Gold Nanoparticles

et al. 2012

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Gold nanoparticles (AuNPs) are considered useful vehicles for medical therapy and diagnosis. Despite the progress made in this field, there is need to find direct, reliable, and versatile synthetic procedures for their preparation as well as new multifunctional coating agents. In this sense, we have explored the use of imidazolium amphiphiles to prepare new AuNPs designed for anion recognition and transport. Thus, in this work we describe (a) the synthesis, by a phase transfer method, of new gold nanoparticles using gemini-type surfactants as ligands based on imidazolium salts, those ligands acting as transfer agents into organic media and also as nanoparticle stabilizers, (b) the examination of their stability in solution, (c) the chemical and physical characterization of the nanoparticles, using a variety of techniques, including UV-visible spectroscopy (UV-vis), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS), (d) toxicity data concerning both the imidazolium ligands and the imidazolium coated nanoparticles, (e) the assessment of their molecular recognition ability toward molecules of biological interest, such as anions and carboxylate containing model drugs, such as ibuprofen, (f) the study of their toxicity and those of their coating ligands, as well as their ability for cell internalization, and (g) the study of their ability for delivering anionic pharmaceuticals. The structurally governed triple role of those new gemini-type surfactants is responsible for the preparation, remarkable stability, and delivery properties of these functional AuNPs.

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Section: ' Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gemini Imidazolium Amphiphiles for the Synthesis, Stabilization, and Drug Delivery from Gold Nanoparticles

et al. 2012

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“…12 Furthermore, amphiphilic sulphur functionalized bis-imidazolium salts have been immobilized on gold surfaces to act as anion sensors. 13 Additionally, open chain and macrocyclic bis-imidazolium salts have exhibited thermotropic liquid crystal properties driven by their counter-ions, 14 and have allowed the preparation of gold nanoparticles acting as anionic drug carriers. 15 There have been only a few reports on the interaction of anionic drugs with cationic micelles that focus on their transport, diffusion and release, 16 and considering their interest in drug delivery, it is important to examine the potential role of cationic micelles as such drug carriers.…”

Section: Introductionmentioning

confidence: 99%

Nanocarriers from dicationic bis-imidazolium amphiphiles and their interaction with anionic drugs

et al. 2013

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Dicationic gemini surfactants based on bis-imidazolium salts with bromide counterions were synthesized and shown to self-assemble into micellar-type structures in aqueous solution. The solubilisation capability of these micelles for anionic drugs (valproate) indicates their great potential as drug nanocarriers. A range of physicochemical techniques including surface tension, fluorescence spectroscopy, small-angle neutron scattering (SANS) and pulsed-gradient spin-echo nuclear magnetic resonance (PGSE-NMR) have been used to determine the nanocarrier (micelle) structure and to quantify the interaction of the drug with the nanocarrier. The insights gained here, structural activity relationships such as hydrophobic dependence of the CMC and drug binding isotherms, will allow for a rational optimization of molecular structure.

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Synthesis and validation of DOPY: A new gemini dioleylbispyridinium based amphiphile for nucleic acid transfection

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Griera

Félix

et al. 2021

European Journal of Pharmaceutics and Biopharmaceutics

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Novel Anionophores for Biosensor Applications: Nano Characterisation of SAMs Based on Amphiphilic Imidazolium Protophanes and Cyclophanes on Gold Surfaces

Cited by 3 publications

References 0 publications

Gemini Imidazolium Amphiphiles for the Synthesis, Stabilization, and Drug Delivery from Gold Nanoparticles

Gemini Imidazolium Amphiphiles for the Synthesis, Stabilization, and Drug Delivery from Gold Nanoparticles

Nanocarriers from dicationic bis-imidazolium amphiphiles and their interaction with anionic drugs

Synthesis and validation of DOPY: A new gemini dioleylbispyridinium based amphiphile for nucleic acid transfection

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