Novel and simple methodology to fabricate porous and buckled fibrous structures for biomedical applications

Controlled release of titanocene into the hybrid nanofibrous scaffolds to prevent the proliferation of breast cancer cells

“…Smaller average diameter nanofibers showed to sustain higher stress at lower strain values. Similar findings(Asran et al, 2010;Luwang Laiva et al, 2014) on the correlated behavior of average fiber diameter and mechanical properties have been reported recently. Also, the mode of existence of drug within the fiber could possibly affect the elastic properties of the polymer.…”

Porous bead-on-string poly(lactic acid) fibrous membranes for air filtration

“…The corresponding highly magnified images shown in Fig. 3b, d, and f demonstrate that there were many mesopores and macropores that were uniformly distributed on the surface of the beads and a few shallow nanopores on the thin fibers, which could be explained by the phase separation and breath figure induced by the rapid evaporation of the solvent and the elongation and solidification of the polymer liquid jets [27,28,34]. The pores on the bead surface tended to increase in number, and the beads collapsed to a lower extent (fewer wrinkles on the beads) as the polymer concentration increased (Fig.…”

Steering surface topographies of electrospun fibers: understanding the mechanisms

“…Although it has been explored for solution, blend and emulsion electrospinning, in-situ structuring of PCL fibers has only recently been under investigation 19, 20, 27, 28 . However, elaborated investigations are required to advance the understanding of the pore formation mechanism during fiber formation.…”

“…Polycaprolactone (PCL), a biodegradable, FDA approved, semi-crystalline polyester which has been shown to be biocompatible for specific applications in the areas of drug delivery, medical sutures, dentistry, wound dressings as well as tissue engineering 38 , has been extensively studied in the electrospinning field. Although it has been explored for solution, blend and emulsion electrospinning, in-situ structuring of PCL fibers has only recently been under investigation 19 , 20 , 27 , 28 . However, elaborated investigations are required to advance the understanding of the pore formation mechanism during fiber formation.…”