Novel and Rapid Diagnostics for Common Infections in the Critically Ill Patient

Pickens, Chiagozie I; Wunderink, Richard G.

doi:10.1016/j.ccm.2022.04.003

Cited by 2 publications

(1 citation statement)

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“…Over the past two decades, rapid, molecular techniques that detect common etiologies of SCAP have been introduced to the microbiology laboratory and clinical setting. 74 Molecular diagnostic tests are generally defined as assays that identify genetic material to diagnose a condition. 63 Many of these platforms address the limitations of respiratory culture.…”

Section: Rapid Molecular Techniques For Severe Community-acquired Pne...mentioning

confidence: 99%

Microbiology of Severe Community-Acquired Pneumonia and the Role of Rapid Molecular Techniques

Pickens,

Gao,

Morales-Nebreda

et al. 2024

Semin Respir Crit Care Med

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The microbiology of severe community acquired pneumonia (SCAP) has implications on management, clinical outcomes and public health policy. Therefore, knowledge of the etiologies of SCAP and methods to identify these microorganisms is key. Bacteria including Streptococcus pneumoniae, Staphylococcus aureus and Enterobacteriaceae continue to be important causes of SCAP. Viruses remain the most commonly identified etiology of SCAP. Atypical organisms are also important etiologies of SCAP and are critical to identify for public health. With the increased number of immunocompromised individuals, less common pathogens may also be found as the causative agent of SCAP. Traditional diagnostic tests, including semi-quantitative respiratory cultures, blood cultures and urinary antigens continue to hold an important role in the evaluation of patients with SCAP. Many of the limitations of the aforementioned tests are addressed by rapid, molecular diagnostic tests. Molecular diagnostics utilize culture-independent technology to identify species-specific genetic sequences. These tests are often semi-automated and provide results within hours, which provides an opportunity for expedient antibiotic stewardship. The existing literature suggests molecular diagnostic techniques may improve antibiotic stewardship in CAP, and future research should investigate optimal methods for implementation of these assays into clinical practice.

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Section: Rapid Molecular Techniques For Severe Community-acquired Pne...mentioning

confidence: 99%