Novel and Promising Systemic Treatment Approaches in Mesothelioma

Dudnik, Elizabeth; Reinhorn, Daniel; Holtzman, Liran

doi:10.1007/s11864-021-00883-8

Cited by 2 publications

(2 citation statements)

References 93 publications

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“…For patients who can undergo surgery, chemotherapy can further prolong their survival ( 32 ). For unresectable or advanced malignant mesothelioma, the current first-line chemotherapy regimen is pemetrexed plus cisplatin ( 54 – 56 ), and a complete chemotherapy regimen is associated with better survival outcomes ( 57 ). In contrast, Barsky et al.…”

Section: Discussionmentioning

confidence: 99%

“…(2) The SEER database lacks detailed clinical data such as surgical methods, specific radiotherapy, and chemotherapy regimens, which may imply other unknown variables. (3) With advances in surgical ( 65 – 67 ) and treatment modalities ( 54 , 61 ), patients with recently diagnosed MMe may have a better prognosis than those included in our study. (4) For the management of MMe patients, no normative standard has yet been established.…”

Section: Limitations and Future Directionsmentioning

confidence: 90%

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Survival analysis and development of a prognostic nomogram for patients with malignant mesothelioma in different anatomic sites

et al. 2022

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BackgroundMalignant mesothelioma (MMe) is a rare and fatal cancer with a poor prognosis. Our study aimed to compare the overall survival (OS) of MMe patients across various sites and develop a prognostic model to provide a foundation for individualized management of MMe patients.MethodsFrom the Surveillance, Epidemiology, and End Results (SEER) database, 1,772 individuals with malignant mesothelioma (MMe) were identified. The X-tile software was used to identify the optimal cut-off point for continuous variables. The Kaplan–Meier method was employed to compare the survival of MMe across different sites. The Cox proportional hazards model was applied to identify the independent risk factors of overall survival (OS) and a nomogram was constructed.ResultsIn the survival analysis, MMe originating from the reproductive organs and hollow organs showed a relatively better prognosis than those originating from soft tissue, solid organs, and pleura. Age, gender, location, histological type, grade of differentiation, extent of disease, lymph node status, lymph node ratio (LNR), and chemotherapy were all found to be independent risk variables for the prognosis of MMe patients (P<0.05) in a multivariate Cox analysis and were included in the construction of nomogram. In the training and testing sets, the C-index of the nomogram was 0.701 and 0.665, respectively, and the area under the ROC curve (AUROC) of the 1-, 3-, and 5-year overall survival rate was 0.749, 0.797, 0.833 and 0.730, 0.800, 0.832, respectively. The calibration curve shows that the nomogram is well-calibrated.ConclusionsThis is the first research to examine the prognosis of MMe patients based on the location. However, previous studies often focused on malignant pleural mesothelioma or malignant peritoneal mesothelioma with high incidence. Furthermore, a nomograph with good prediction efficiency was established according to the variables that influence patient survival outcomes, which provides us with a reference for clinical decision-making.

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