Novel and facile methods for the synthesis of DTPA-mono-amide: a new completely revised strategy in radiopharmaceutical chemistry

Ardestani, Mehdi Shafiee; Arabzadeh, Ali Jabbari; Heidari, Zahra; Hosseinzadeh, A; Ebrahimi, Hamidreza Khoshnezhad; Hashemi, Elham; Mosayebnia, Mona; Shafiee-Alavidjeh, Mohammad; Alavi, A.; Babaei, Mohammad; Rahmim, Arman; Ebrahimi, Seyed Esmaeil Sadat; Amanlou, Massoud

doi:10.1007/s10967-009-0414-y

Cited by 21 publications

(12 citation statements)

References 19 publications

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“…As shown in Figures 1(a) and (b), Gd 2 O 3 @PCD-Glu NPs are spherical in shape and seemed to be uniform, which is in good agreement with the results of DLS analysis. Slight differences between data from FE-SEM and DLS could be as a result of the various processes involved in preparing the samples [30].…”

Section: Morphological Analysis Of Npsmentioning

confidence: 99%

Glucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis in MRI

et al. 2020

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Background: Glucose transporter (Glut), a cellular transmembrane receptor, has a key role in the metabolism of cell glucose and is also associated with various human carcinomas. Objective: In this study, we evaluated a magnetic resonance (MR) imaging contrast agent for tumor detection based on paramagnetic gadolinium oxide (Gd2O3) coated polycyclodextrin (PCD) and modified with glucose (Gd2O3@PCD-Glu) for the targeting of overexpressed glucose receptors. Material and Methods: In this experimental study, 3T magnetic resonance imaging (MRI) scanner was used to assess the specific interactions between Glut1-overexpressing tumor cells (MDA-MB-231) and Gd2O3@PCD-Glu NPs. Furthermore, the capacity of transporting Gd2O3@PCD-Glu NPs to tumor cells was evaluated. Results: It was found that the acquired MRI T1 signal intensity of MDA-MB-231 cells that were treated with the Gd2O3@PCD-Glu NPs increased significantly. Based on the results obtained, Gd2O3@PCD-Glu NPs can be applied in targeting Glut1-overexpressing tumor cells in vivo, as well as an MRI-targeted tumor agent to enhance tumor diagnosis. Conclusion: Results have shown that glucose-shell of magnetic nanoparticles has a key role in diagnosing cancer cells of high metabolic activity.

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Section: Morphological Analysis Of Npsmentioning

confidence: 99%

Glucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis in MRI

et al. 2020

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“…To couple dopamine‐bisphytanyl to DTPA dianhydride, while minimising the formation of DTPA‐bisdopamine‐bisphytanyl, the procedure suggested by Ardestani et al 35. (procedure B2 in the actual article) was used with minor modifications, as noted here.…”

Section: Methodsmentioning

confidence: 99%

Gd‐DTPA‐Dopamine‐Bisphytanyl Amphiphile: Synthesis, Characterisation and Relaxation Parameters of the Nanoassemblies and Their Potential as MRI Contrast Agents

Gupta

Willis

Waddington

et al. 2015

Chemistry A European J

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Here, a new amphiphilic magnetic resonance imaging (MRI) contrast agent, a Gd(III)-chelated diethylenetriaminepentaacetic acid conjugated to two branched alkyl chains via a dopamine spacer, Gd-DTPA-dopamine-bisphytanyl (Gd-DTPA-Dop-Phy), which is readily capable of self-assembling into liposomal nanoassemblies upon dispersion in an aqueous solution, is reported. In vitro relaxivities of the dispersions were found to be much higher than Magnevist, a commercially available contrast agent, at 0.47 T but comparable at 9.40 T. Analysis of variable temperature (17)O NMR transverse relaxation measurements revealed the water exchange of the nanoassemblies to be faster than that previously reported for paramagnetic liposomes. Molecular reorientation dynamics were probed by (1)H NMRD profiles using a classical inner and outer sphere relaxation model and a Lipari-Szabo "model-free" approach. High payloads of Gd(III) ions in the liposomal nanoassemblies made solely from the Gd-DTPA-Dop-Phy amphiphiles, in combination with slow molecular reorientation and fast water exchange makes this novel amphiphile a suitable candidate to be investigated as an advanced MRI contrast agent.

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“…24 Because of the disadvantage, that one ligand carboxylate metal binding site is occupied forming an amide bond in the coupling of DTPA-CA, another approach is the synthesis of DTPA monoamides using EDC or DCC. 32 Alternatively, p-SCN-DTPA has been synthesized. 33 After conjugation of p-SCN-DTPA to an anti-CD45 mab, 68 Ga labeling was performed in 1 M sodium acetate (pH ¼ 5.0) for 10 minutes at RT to guarantee radiochemical purities 495%.…”

Section: Dtpamentioning

confidence: 99%

Bifunctional Gallium-68 Chelators: Past, Present, and Future

Spang

Herrmann

Roesch

2016

Seminars in Nuclear Medicine

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Novel and facile methods for the synthesis of DTPA-mono-amide: a new completely revised strategy in radiopharmaceutical chemistry

Cited by 21 publications

References 19 publications

Glucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis in MRI

Glucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis in MRI

Gd‐DTPA‐Dopamine‐Bisphytanyl Amphiphile: Synthesis, Characterisation and Relaxation Parameters of the Nanoassemblies and Their Potential as MRI Contrast Agents

Bifunctional Gallium-68 Chelators: Past, Present, and Future

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