Novel and extended HLA class I and II alleles encountered in Kashmiri Brahmin population from North India

Abstract

Three novel HLA‐A*02:06:01:04, ‐DRB1*12:02:01:02, ‐DQB1*03:01:01:07 and five extended HLA‐B*51:01:05, ‐DRB1*12:02:01:01, ‐DRB1*14:01:01, ‐DRB1*14:04:01:01, ‐DRB1*15:04 alleles.

Intron 2 substitution resulted in HLA‐DQB1*02:01:01:02 variant in a Kashmiri Brahmin individual from North India

“…We previously reported a novel allele, HLA‐A*33:03:01:06 in this population 2 . Our recent report revealed presence of three more novel alleles HLA‐A*02:06:01:04 , ‐ DRB1*12:02:01:02 , ‐ DQB1*03:01:01:07 and five extended alleles HLA‐B*51:01:05 , ‐ DRB1*12:02:01:01 , ‐ DRB1*14:01:01 , ‐ DRB1*14:04:01:01 , ‐ DRB1*15:04 in this community 3 . While continuing to exploring the HLA profile of Kashmiri Brahmins using NGS based HLA typing we identified another novel HLA‐DQB1 variant, now named HLA‐DQB1*02:01:01:02 .…”

Nomenclature for factors of the HLA system, update October, November and December 2020

“…A*02:06:01:04 (Saxena et al, 2020) A*02:346 (K. L. Yang, Li, & Lin, 2020a) A*02:402 (Prasath et al, 2020) A*02:411 (Li, Zhang, Lin, Jiang, & Li, 2020) A*02:686 A*02:696N A*02:787 (W. A*02:935 (K. L. Yang, Li, & Lin, 2020c)…”

HLA-SPREAD: a natural language processing based resource for curating HLA association from PubMed abstracts

“…The expanse of this information is immense as there is wide genetic variability and heterogeneity among populations [6]. Although advancements in HLA typing technologies has been beneficial in identifying novel HLA sequences [30], this has also led to reporting the same HLA allelic variant using different HLA nomenclature.…”