“…Among this class of compounds, 5‐arylidene‐3‐aryl‐2‐thiohydantoins and their S ‐alkylated, N ‐alkylated, and N ‐glycosylated derivatives are a biologically important class of compounds in the fields of drugs, pharmaceutical intermediates, and agrochemicals [1,3]. For example, the 3‐substituted 5‐arylidene‐2‐thiohydantoin moiety is known to be a biologically active heterocyclic core in the areas of antiviral [4,5], anticonvulsant [6,7], antifungal [8,9], antibacterial [9,10], schistosomicidal [11], antidiabetic [12], anxiolytic [13], anticancer [14–21], and antiproliferative [22] activities (Figure 1). Also, compound I was designed and synthesized for detecting tau pathology in the brains of patients with Alzheimer's disease [23]; whereas compound II exihibits properties as potential inhibitors of NADPH oxidase (NOX) 1 and 4 [24] (Figure 1).…”