Novel and Efficient One-Pot Synthesis of (Aminophenyl)carbamic Acid Esters

Garofalo, Antonio; Goossens, Laurence; Six, Perrine; Lebegue, Nicolas; Depreux, Patrick

doi:10.1080/00397911.2010.494818

Cited by 4 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Finally, the signals between 6.95 and 7.55 ppm were assigned to the aryl protons of toluene dicarbamate isomers (TDC); the even higher chemical shifts are due to the presence of two carbamate groups. These trends of the chemical shifts in the mono‐ and dicarbamates were confirmed by comparison with the spectra of the corresponding mono‐ and diethylcarbamates …”

Section: Resultsmentioning

confidence: 88%

Recycling of Flexible Polyurethane Foam by Split‐Phase Alcoholysis: Identification of Additives and Alcoholyzing Agents to Reach Higher Efficiencies

Vanbergen

Verlent²,

Geeter³

et al. 2020

ChemSusChem

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 88%

Recycling of Flexible Polyurethane Foam by Split‐Phase Alcoholysis: Identification of Additives and Alcoholyzing Agents to Reach Higher Efficiencies

Vanbergen

Verlent²,

Geeter³

et al. 2020

ChemSusChem

View full text Add to dashboard Cite

show abstract

“…Kayu jati juga memiliki banyak senyawa bioaktif (Neamatallah et al 2005;Thulasidas et al 2006;Lacret et al 2011;Syofuna et al 2012), dan senyawa yang mampu menghilangkan logam berat (Rao et al 2010). Beberapa senyawa telah diisolasi dari hampir setiap bagian jati seperti senyawa steroid, asam fenolat, dan senyawa antioksidan (Lukmandaru & Takahashi 2008;Gorafalo et al 2011;Setiawan et al 2013).…”

Section: Pendahuluanunclassified

Identification Content Extract of Teak Wood Using Py-GCMS

Fendi¹,

Kurniaty²

2016

jipi

View full text Add to dashboard Cite

ABSTRAK Kayu jati (Tectona grandis Lf.) dalam bentuk serbuk gergaji merupakan hasil samping/limbah dari industri furniture yang memiliki jumlah cukup banyak dan belum termanfaatkan secara optimal. Penelitian ini bertujuan untuk mengetahui kandungan ekstraktif kayu jati (Tectona grandis Lf.). Metode yang digunakan adalah kelarutan dalam air panas. Serbuk kayu jati muna seberat 4,076 g direndam akuades sebanyak 100 ml dalam labu kaca, kemudian dipanaskan dalam penangas air pada suhu 100 C selama 3 jam. Kandungan ekstraktif yang terlarut dalam cairan, selanjutnya dikarakterisasi menggunakan Py-GCMS. Hasil analisis Py-GCMS pada ekstrak serbuk kayu jati menunjukkan adanya konsentrasi beberapa zat, antara lain Carbamic acid (70,70%), mono ammonium salt (CAS) Ammonium carbamate (70,70%), Acetic acid (CAS) Ethylic acid (10,52%), Acetic acid (CAS) Ethylic acid (2,35%), Acetic acid (CAS) Ethylic acid (3,26%), dan Phenol (CAS) Izal (13,17%).

show abstract

“…40−42 The synthesis of (aminophenyl)carbamic acid esters 11−27 was performed by a one-pot reduction procedure of the corresponding nitrophenyl isocyanate in the presence of various alcohols in a CH 2 Cl 2 /THF mixture. 46 Condensation of 1,4phenylenediamine and the corresponding isocyanate in CHCl 3 afforded the desired ureas 28−32 in high yields and short reaction times. 47 Amide analogues 33 and 34 were prepared from 2methyl-4-nitroaniline according to a two-step procedure: acetylation from chloride derivatives and reduction under a hydrogen atmosphere using Raney nickel as the catalyst.…”

Section: ■ Chemistrymentioning

confidence: 99%

“…The synthesis of (aminophenyl)carbamic acid esters 11 – 27 was performed by a one-pot reduction procedure of the corresponding nitrophenyl isocyanate in the presence of various alcohols in a CH 2 Cl 2 /THF mixture . Condensation of 1,4-phenylenediamine and the corresponding isocyanate in CHCl 3 afforded the desired ureas 28 – 32 in high yields and short reaction times .…”

Section: Chemistrymentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and Structure–Activity Relationships of (Aryloxy)quinazoline Ureas as Novel, Potent, and Selective Vascular Endothelial Growth Factor Receptor-2 Inhibitors

et al. 2012

Self Cite

View full text Add to dashboard Cite

In our continuing search for medicinal agents to treat proliferative diseases, quinazoline derivatives were synthesized and evaluated pharmacologically as epithelial growth factor receptor and vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase inhibitors. A quantitative structure-activity relationship analysis was conducted to rationalize the structure-activity relationship and to predict how similar the inhibitor-binding profiles of two protein kinases are likely to be on the basis of the docking of lead coumpounds into the ATP-binding site. This model was used to direct the synthesis of new compounds. A series of N-(aromatic)-N'-{4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}urea were identified as potent and selective inhibitors of the tyrosine kinase activity of VEGFR-2 (fetal liver kinase 1, kinase insert domain-containing receptor). An efficient route was developed that enabled the synthesis of a wide variety of analogues with substitution on several positions of the template. Substitution of diarylurea, competitive with ATP, afforded several analogues with low nanomolar inhibition of enzymatic activity of VEGFR-2. In this paper, we describe the synthesis, structure-activity relationships, and pharmacological characterization of the series.

show abstract

Novel and Efficient One-Pot Synthesis of (Aminophenyl)carbamic Acid Esters

Cited by 4 publications

References 13 publications

Recycling of Flexible Polyurethane Foam by Split‐Phase Alcoholysis: Identification of Additives and Alcoholyzing Agents to Reach Higher Efficiencies

Recycling of Flexible Polyurethane Foam by Split‐Phase Alcoholysis: Identification of Additives and Alcoholyzing Agents to Reach Higher Efficiencies

Identification Content Extract of Teak Wood Using Py-GCMS

Synthesis and Structure–Activity Relationships of (Aryloxy)quinazoline Ureas as Novel, Potent, and Selective Vascular Endothelial Growth Factor Receptor-2 Inhibitors

Contact Info

Product

Resources

About