Novel Anatomical Findings of the Prostatic Gland and the Surrounding Capsular Structures in the Normal Prostate

Ishidoya, Shigeto; Endoh, Mareyuki; Nakagawa, Haruo; Saito, Seiichi; Arai, Yoichi

doi:10.1620/tjem.212.55

Cited by 21 publications

(19 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the basis of these differences the marmoset prostate can also be divided into two lobes which correspond with the other three species. In all these monkey species, the glandular prostate does not completely surround the urethra (Figure 1) and in this regard differs from what has been reported in humans [6,7]. …”

Section: Resultscontrasting

confidence: 70%

Nonhuman primates as models for studies of prostate specific antigen and prostatic diseases

et al. 2008

View full text Add to dashboard Cite

Background-Because prostate specific antigen (PSA) is released at increased levels into the blood early in the development of prostate cancer, benign prostatic hyperplasia (BPH) and prostatitis, it is widely used as a marker for these diseases. However, PSA has clinical limitations as a screen for prostatic diseases due to its low sensitivity and specificity. There is a strong need to better understand the biology of PSA and factors affecting its serum levels.

show abstract

Section: Resultscontrasting

confidence: 70%

Nonhuman primates as models for studies of prostate specific antigen and prostatic diseases

et al. 2008

View full text Add to dashboard Cite

show abstract

“…For the purpose of the present study, we used 'prostatic fascia' which surrounds the prostate gland instead of prostatic capsule because the prostate does not have a true capsule [16]. The 'lateral prostatic fascia' is defined as periprostatic tissue and the outer layer of the periprostatic tissue is termed the 'lateral pelvic fascia' [4, [13][14][15][16]. Kiyoshima et al [11] reported that the 'prostatic fascia' at the apex and the base of the prostate in sagittal sections was not recognised, as the outermost region of the prostate blends smoothly with the pelvic floor and the bladder wall.…”

Section: Discussionmentioning

confidence: 99%

Pathological confirmation of nerve‐sparing types performed during robot‐assisted radical prostatectomy (RARP)

Ko¹,

Hruby

Turk

et al. 2012

BJU International

View full text Add to dashboard Cite

• Incremental nerve-sparing techniques (NSTs) improve postoperative erectile function after robot-assisted radical prostatectomy (RARP).• However, there are no studies to date that histologically confirm the surgeon intended NST. Thus, in the present study, we histologically confirmed that the surgeon performed the nerve preservation as his intended NSTs during RARP. Also, we found that there was more variability in fascia width outcome on the left side compared with the right. Therefore, when performing nerve preservation on the surgeon's non-dominant side, we need to pay more close attention. Objectives• To confirm that the surgeon achieved true intended histological nerve sparing during robot-assisted radical prostatectomy (RARP) by studying RP specimens.• To aid the novice robotic surgeon to develop the skills of RARP. were compared across nerve-sparing types (NSTs). FW was recorded at 15°intervals (3-9 o'clock position), measured as the distance between the outermost prostate gland and surgical margin. Patients and Methods• The slides were reviewed by an experienced uropathologist who was 'blinded' to the NST. Results• In all, 93 men were included. The overall mean (SD) FW was the greatest in the order of WR, ITE-NS, and ITR-NS, at 2.42 (1.62), 1.71 (1.40) and 1.16 (1.08) mm, respectively (P < 0.001).• FW was statistically significantly correlated with the surgical technique used. When the surgeon intended to perform various levels of nerve sparing, these were reflected in the FW.• Interestingly, the left-side FW showed more variability than the right side. We suspect that this was a result of the surgeon's right-hand dominance.• Erectile function (EF) recovery rate according to NST was 88.9%, 77.3%, 65.6%, 56.3%, and 0% in bilateral ITR-NS, ITR-NS/ITE-NS, bilateral ITE-NS, ITE-NS/WR, and bilateral WR, respectively. • To further validate and confirm these preliminary findings, additional studies involving multicentre cohorts would be required. Conclusions• The surgeon intended dissection and FW correlate, with ITR-NS providing the narrowest FW and the EF recovery rate was the highest in bilateral ITR-NS. There was more variability in FW outcome on the left side than the right.• The novice robotic surgeon should consider this variability when performing RARP. It may have implications for technique improvement on nerve preservation for EF.

show abstract

“…Despite frequent reference, the gland lacks a discrete capsule. This is particularly true on the anterior third at the apex, where the tissue is in reality a fibromuscular stroma: an amalgamation of striated muscle, prostate glands, and elastic fibers 22,23 . It is therefore unsurprising, due to variations in the shape and the known presence of extraprostatic glands in this area despite complete prostate excision, that glands may be found at this anterior apical margin where the dorsal venous complex is divided.…”

Section: Commentmentioning

confidence: 99%

Benign Prostate Glandular Tissue at Radical Prostatectomy Surgical Margins

Odisho¹,

Washington²,

Meng³

et al. 2013

Urology

View full text Add to dashboard Cite

Objective To determine whether presence of benign glandular tissue at the radical prostatectomy surgical margin is associated with technique (open (ORP) or robotic assisted laparoscopic radical prostatectomy (RALRP)) and if benign glandular tissue increases the risk of biochemical recurrence. Methods Surgical specimens from men with clinical T1–T2 disease who underwent RP between 2004–2010 were re-reviewed by a single uropathologist, examining all sections from the prostate apex and base for the presence of benign glandular tissue and tumor at the margin. Regression analysis was utilized to examine associations of benign glandular tissue with surgical approach and biochemical recurrence. Results Of 934 cases reviewed, 431 were managed by ORP and 503 by RALRP with a median follow up of 48 and 25 months, respectively. Overall, benign glandular tissue was found in 274 (29%) cases: 98 (36%) at the apex, 138 (50%) at the base and 38 (14%) at both. Compared with those who underwent ORP, patients who underwent RALRP had 3-fold greater odds of benign glandular tissue at the margin (P<0.01), including significantly greater number of cases with benign glandular tissue at the base (P<0.01). However, recurrence-free survival rates were similar between patients with and without BGM regardless of surgical approach and across all clinical risk groups (log-rank P=0.20). Conclusions Patients undergoing RALRP were more likely to have benign glandular tissue at the surgical margin. However, the presence of benign glandular tissue was not an independent risk factor for biochemical recurrence.

show abstract

Novel Anatomical Findings of the Prostatic Gland and the Surrounding Capsular Structures in the Normal Prostate

Cited by 21 publications

References 11 publications

Nonhuman primates as models for studies of prostate specific antigen and prostatic diseases

Nonhuman primates as models for studies of prostate specific antigen and prostatic diseases

Pathological confirmation of nerve‐sparing types performed during robot‐assisted radical prostatectomy (RARP)

Benign Prostate Glandular Tissue at Radical Prostatectomy Surgical Margins

Contact Info

Product

Resources

About