Novel Anastomotic Technique for Uterine Transplant Using Utero-ovarian Veins for Venous Drainage and Internal Iliac Arteries for Perfusion in Two Laparoscopically Harvested Uteri

Puntambekar, Shailesh; Puntambekar, S.; Telang, M.; Kulkarni, Pankaj; Date, Shardul; Panse, Mangesh; Sathe, Ravindra; Agarkhedkar, Nikhil; Warty, Neeta; Kade, Sandesh; Manchekar, Manoj; Chitale, Mihir; Parekh, Hirav; Parikh, Kajal; Mehta, Mehul; Kinholkar, Bhushan; Jana, Joy Shankar; Pare, Avinash; Kanade, Shailendra; Sadre, Abhay; Hardikar, Shirish; Jathar, Advait; Bakre, T.; Chate, Meenakshi; Tiruke, Raviraj

doi:10.1016/j.jmig.2018.11.021

Cited by 66 publications

(99 citation statements)

References 19 publications

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“…Of the UTx procedures reported so far, 80% ( n = 36) have been performed using living donors – in Saudi Arabia, Sweden, China, Czech Republic, the USA, Germany, and India . Other procedures have been performed in Serbia, Lebanon, and Belgium but remain unpublished.…”

Section: Donorsmentioning

confidence: 99%

“…The majority of donor surgeries performed so far have been through the laparotomy approach ( n = 39), but minimally invasive surgical techniques have been used in living donors (robotic, n = 2; laparoscopic, n = 4) . Table S1 (see Supplementary material) summarises the key surgical information from the procedures performed to date.…”

Section: Surgical Techniquementioning

confidence: 99%

“…The graft arterial supply is mostly anastomosed end‐to‐side with the recipient's external iliac vessels ( n = 42; 93.3%). Three procedures (6.6%) anastomosed the graft arteries to the internal iliac arteries, two of which used an end‐to‐end technique, ensuring exclusive arterial supply to the uterus …”

Section: Surgical Techniquementioning

confidence: 99%

See 2 more Smart Citations

Human uterine transplantation: a review of outcomes from the first 45 cases

Jones

Saso

Bracewell‐Milnes

et al. 2019

BJOG

138

195

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Uterine transplantation restores reproductive anatomy in women with absolute uterine factor infertility and allows the opportunity to conceive, experience gestation, and acquire motherhood. The number of cases being performed is increasing exponentially, with detailed outcomes from 45 cases, including nine live births, now available. In light of the data presented herein, including detailed surgical, immunosuppressive and obstetric outcomes, the feasibility of uterine transplantation is now difficult to refute. However, it is associated with significant risk with more than one-quarter of grafts removed because of complications, and one in ten donors suffering complications requiring surgical repair.Tweetable abstract Uterine transplantation is feasible in women with uterine factor infertility, but is associated with significant risk of complication.

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Section: Donorsmentioning

confidence: 99%

Section: Surgical Techniquementioning

confidence: 99%

See 1 more Smart Citation

Human uterine transplantation: a review of outcomes from the first 45 cases

Jones

Saso

Bracewell‐Milnes

et al. 2019

BJOG

138

195

View full text Add to dashboard Cite

show abstract

“…While for the premenopausal living donor, if the ovarian vein is used for the uterine outflow, the recipient has to take HRT postsurgery. Due to the challenges in extensive dissection and anatomic variability of the uterine veins, some doctors prefer to use the ovarian vein while uterine vein seems to be optional . However, using the ovarian veins while preserving the donor's ovaries in situ to reduce the side effect on the endocrine function of the LD requires further exploration.…”

Section: The Morality Of Utx In Chinamentioning

confidence: 99%

“…Due to the challenges in extensive dissection and anatomic variability of the uterine veins, some doctors prefer to use the ovarian vein while uterine vein seems to be optional. 1,63,64 However, using the ovarian veins while preserving the donor's ovaries in situ to reduce the side effect on the endocrine function of the LD requires further exploration. The current view is that the use of ovarian veins requires removal of the donor's ovaries, so it is recommended that ovarian veins be used only for donors who have been menopausal or those of the DD.…”

Section: The Morality Of Utx In Chinamentioning

confidence: 99%

Clinical applications of uterus transplantation in China: Issues to take into consideration

Liu

Zhang

Ding

et al. 2020

J of Obstet and Gynaecol

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Uterus transplantation (UTx) is an emerging surgical treatment for patients with absolute uterine factor infertility. However, the initial low surgical success of human UTx from the teams worldwide has revealed the difficulty of the surgery and called for preparatory team training in large animals. Also, the team who carried out the human UTx without previous systematic research in large animals or deceased donors encountered transplant failures, which was controversial and even deprived them of further trials. Various UTx studies in large animals, including dogs, pigs, sheep and macaques have been performed in China from different teams, compared to other countries around the world. However, among over 70 UTx that have been carried out worldwide, only three were carried out in China, with one live baby achieved. In this paper, we explore the possible challenges for human UTx in China. We conclude that it is critical to learn the lessons from the international team and adopt the international ethic views regarding UTx on humans. Also, it would be positive for the Chinese groups to establishing an academic society for UTx with regular meetings, which will raise public awareness of UTx, and guide the proper development of human UTx in China.

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Uterus Transplantation in the Context of Fertility Preservation

Brännström

2022

Female and Male Fertility Preservation

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Novel Anastomotic Technique for Uterine Transplant Using Utero-ovarian Veins for Venous Drainage and Internal Iliac Arteries for Perfusion in Two Laparoscopically Harvested Uteri

Cited by 66 publications

References 19 publications

Human uterine transplantation: a review of outcomes from the first 45 cases

Human uterine transplantation: a review of outcomes from the first 45 cases

Clinical applications of uterus transplantation in China: Issues to take into consideration

Uterus Transplantation in the Context of Fertility Preservation

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