2022
DOI: 10.1016/j.ejmech.2022.114615
|View full text |Cite
|
Sign up to set email alerts
|

Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2022
2022
2023
2023

Publication Types

Select...
2

Relationship

1
1

Authors

Journals

citations
Cited by 2 publications
(2 citation statements)
references
References 38 publications
0
2
0
Order By: Relevance
“…Molecular docking studies were performed in Maestro suite release 2020–3 employing Glide software. 50 , 51 The 3D structures of h COX-1 and h COX-2 (PDB IDs 6Y3C and 5KIR, respectively) were retrieved from the Protein Data Bank and acquiesced to the Protein Preparation Wizard protocol executed in Maestro for obtaining appropriate structures for the computational studies. The structures of the ligands were built in Maestro employing the available drawing tools, while energy minimization was achieved by using MacroModel program with OPLS-2005 as the force field.…”
Section: Methodsmentioning
confidence: 99%
“…Molecular docking studies were performed in Maestro suite release 2020–3 employing Glide software. 50 , 51 The 3D structures of h COX-1 and h COX-2 (PDB IDs 6Y3C and 5KIR, respectively) were retrieved from the Protein Data Bank and acquiesced to the Protein Preparation Wizard protocol executed in Maestro for obtaining appropriate structures for the computational studies. The structures of the ligands were built in Maestro employing the available drawing tools, while energy minimization was achieved by using MacroModel program with OPLS-2005 as the force field.…”
Section: Methodsmentioning
confidence: 99%
“…Novel chalcone compounds have excellent COX-2 inhibitory activity, can effectively suppress EGFR expression levels, and can overcome gastrointestinal side effects ( 122 , 123 ). Novel COX-2 inhibitors 5-diaryl pyrrole nitrooxyethyl sulfide and related compounds, which could achieve potent anti-inflammatory effects with an overall safety profile and reduced gastrointestinal toxicity ( 124 ).…”
Section: Cyclo-oxygen-ase-2 Inhibitorsmentioning
confidence: 99%