Novel Alkaloids, Paxdaphnines A and B with Unprecedented Skeletons from the Seeds of Daphniphyllum paxianum.

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Discovery of structurally diverse and bioactive compounds from plant resources in China

“…Since we published the first chemical studies on D subverticillatum in 2003, a total of 194 structurally complex alkaloids have been isolated from 9 species of Daphniphyllum in our research group, 72 of which were novel structures. Among the novel compounds, 14 of them had new skeletons or possessed rearranged carbon frameworks [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] . Some alkaloids showed strong cytotoxic activity [16] .…”

“…A series of Daphniphyllum alkaloids possessing cage-like skeletons were isolated from the seeds of D paxianum [11] and D macropodum [18] . Compounds 8-11 are the representatives of these cage-like Daphniphyllum alkaloids; in particular, paxdaphnine A (11) is the first identified 1,19-bisnorDaphniphyllum alkaloid with a highly caged skeleton and a constrained Ring-A by the formation of C2-C8 and C1-C9 bonds, whose absolute configuration was determined by X-ray diffraction of its iodide derivative.…”