Novel alginate-amino fatty acid amide composite hybrid gel beads as nanocarriers for in vitro release of silver nanoparticles

Yadav, Eqvinshi; Sebastian, Sharol; Bhardwaj, Priya; Maruthi, Mulaka; Gupta, Manoj K.

doi:10.1016/j.mtcomm.2023.106372

Cited by 5 publications

(1 citation statement)

References 75 publications

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“…6–8 The formation of 3D networks by LMWGs has displayed remarkable potential as a “bottom-up” approach for developing innovative materials with diverse applications. These applications include sensing, 9 enzyme immobilization and organocatalysis, 10,11 catalysis, 12 tissue engineering and pharmaceutical delivery systems, 13–17 crystallization, 18 pollutant removal, 19 3D printing, 20 and more. The physical properties of gels, such as stiffness and porosity, coupled with advancements in structural features, have opened up new possibilities for manipulating the behaviour of LMWGs.…”

Section: Introductionmentioning

confidence: 99%

Facile one-pot multicomponent synthesis of peptoid based gelators as novel scaffolds for drug incorporation and pH-sensitive release

Sebastian,

Yadav,

Bhardwaj

et al. 2023

J. Mater. Chem. B

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Section: Introductionmentioning

confidence: 99%

Facile one-pot multicomponent synthesis of peptoid based gelators as novel scaffolds for drug incorporation and pH-sensitive release

Sebastian,

Yadav,

Bhardwaj

et al. 2023

J. Mater. Chem. B

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N‐Hydroxyalkanamide Based Organo/hydrogels as Novel Scaffolds for pH‐Dependent Metronidazole and Theophylline Release

Monika,

Meenakshi,

Brahma

et al. 2024

Chemistry & Biodiversity

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The traditional delivery of metronidazole and theophylline presents challenges like bitter taste, variable absorption, and side effects. However, gel‐based systems offer advantages including enhanced targeted drug delivery, minimized side effects, and improved patient compliance, effectively addressing these challenges. Consequently, a cost‐effective synthesis of N‐hydroxyalkanamide gelators with varying alkyl chain lengths was achieved in a single‐step reaction procedure. These gelators formed self‐assembled aggregates in DMSO/water solvent system, resulting in organo/hydrogels at a minimum gelation concentration of 1.5% w/v. Subsequently, metronidazole and theophylline were encapsulated within the gel core and released through gel‐to‐sol transition triggered by pH variation at 37 °C, while maintaining the structural‐activity relationship. UV‐vis spectroscopy was employed to observe the drug release behavior. Furthermore, in vitro cytotoxicity assays revealed cytotoxic effects against A549 lung adenocarcinoma cells, indicating anti‐proliferative activity against human lung cancer cells. Specifically, the gel containing theophylline (16HAD+Th) exhibited cytotoxicity on cancerous A549 cells with IC50 values of 19.23 ± 0.6 µg/mL, followed by the gel containing metronidazole (16HAD+Mz) with IC50 values of 23.75 ± 0.7 µg/mL. Moreover, the system demonstrated comparable antibacterial activity against both gram‐negative (E. coli) and gram‐positive bacteria (S. aureus).

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Photopatterned Hybrid Supramolecular/Polymer Hydrogels for Controlled Heparin Release and Stem Cell Growth

López‐Acosta,

Chivers,

Piras

et al. 2024

ChemNanoMat

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This paper reports hybrid gels combining a low‐molecular‐weight gelator (LMWG) and a photoinitiated crosslinked polymer gel (PG). The presence of the PG enhanced the stiffness and strength of the gel. The gels were loaded with heparin, and in the hybrid gel, the interpenetrated LMWG and PG networks somewhat restricted its release. In terms of stem cell growth, the hybrid gel significantly improved the performance of the PG because of the presence of the LMWG, which is an excellent substrate for stem cells in its own right. Furthermore, the presence of heparin in the hybrid gels also enhanced stem cell proliferation over longer timescales. Finally, these gels were photopatterned within the well‐plates used for tissue culture, with patterning helping control stem cell proliferation. In summary, these hybrid gels combine the advantageous features of both LMWG and PG: rheological performance is endowed by the PG with stem cell compatibility provided by the LMWG. The hybrid gels also control the release of the bioactive agent heparin and have capacity to be shaped and patterned. Patterned gels such as these, capable of directing stem cell growth, have potential in regenerative medicine.

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Novel alginate-amino fatty acid amide composite hybrid gel beads as nanocarriers for in vitro release of silver nanoparticles

Cited by 5 publications

References 75 publications

Facile one-pot multicomponent synthesis of peptoid based gelators as novel scaffolds for drug incorporation and pH-sensitive release

Facile one-pot multicomponent synthesis of peptoid based gelators as novel scaffolds for drug incorporation and pH-sensitive release

N‐Hydroxyalkanamide Based Organo/hydrogels as Novel Scaffolds for pH‐Dependent Metronidazole and Theophylline Release

Photopatterned Hybrid Supramolecular/Polymer Hydrogels for Controlled Heparin Release and Stem Cell Growth

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