Novel Albumin-Binding Multifunctional Probe Gd-EB-ICG for Synergistic Enhancement of FL/MR Dual-Modal Imaging and Photothermal Cancer Therapy

Abstract

This study presents a novel multifunctional probe Gd-EB-ICG based on albumin-binding for synergistic enhancement of fluorescence (FL) and magnetic resonance (MR) imaging-guided photothermal cancer therapy. In vitro experiments demonstrated that Gd-EB-ICG exhibits superior fluorescence intensity, longitudinal relaxivity, and photothermal conversion efficiency. In vivo experiments demonstrated that Gd-EB-ICG exhibits excellent tumor aggregation, imaging, and killing effects. This simple and feasible strategy successfully resulted in a synergistic effect for FL/MR dual-modal imaging and photothermal therapy.