Novel Agents in Neuropathic Pain, the Role of Capsaicin: Pharmacology, Efficacy, Side Effects, Different Preparations

Hall, O. Morgan; Broussard, Alaina; Range, Tierra; Turpin, Michelle A. Carroll; Ellis, S; Lim, Victoria M.; Cornett, Elyse M.; Kaye, Alan D.

doi:10.1007/s11916-020-00886-4

Cited by 29 publications

(38 citation statements)

References 54 publications

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“…Formulations containing CP are clinically approved for local pain control. For instance, topical CP is used to treat HIV-1-associated distal sensory polyneuropathy and postherpetic neuralgia (7), and CP creams are applied vaginally to treat vulvar vestibulitis syndrome (43). As CP is a known irritant, its topical application induces an initial burning ‘flare’ sensation associated with nociceptor activation.…”

Section: Discussionmentioning

confidence: 99%

“…As CP is a known irritant, its topical application induces an initial burning ‘flare’ sensation associated with nociceptor activation. Such discomfort is limited to the site of application and resolves after the first few days (7). On-going studies are exploring strategies to improve CP bioavailability (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…As TRPV1-mediated neuronal excitation evoked by CP, but not other TRPV1 agonists, is followed by a long lasting refractory period with unresponsiveness to additional noxious stimuli (i.e. desensitization), CP topical mucosal formulations and skin patches have been approved clinically as analgesics in painful conditions (7).…”

Section: Introductionmentioning

confidence: 99%

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Capsaicin activates TRPV1 in human Langerhans cells and inhibits mucosal HIV-1 transmission via secreted CGRP

Cohen

Zhu

Auffray

et al. 2021

Preprint

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Upon its mucosal transmission, human immunodeficiency virus type 1 (HIV-1) rapidly targets resident antigen-presenting Langerhans cells (LCs) in genital epithelia, which subsequently transinfect CD4+ T-cells. We previously described an inhibitory neuro-immune sensory mucosal crosstalk, whereby peripheral pain-sensing nociceptor neurons, innervating all mucosal epithelia and associating with LCs, secret the neuropeptide calcitonin gene-related peptide (CGRP) that strongly inhibits HIV-1 trans-infection. Moreover, we reported that LCs secret low levels of CGRP that are further increased by CGRP itself via an autocrine/paracrine mechanism. As nociceptors secret CGRP following activation of their Ca2+ ion channel transient receptor potential vanilloid 1 (TRPV1), we investigated whether LCs also express functional TRPV1. We found that human LCs expressed TRPV1 mRNA and protein. TRPV1 in LCs was functional, as the TRPV1 agonists capsaicin (CP) and resiniferatoxin (RTX) induced Ca2+ influx in a dose-dependent manner. Treatment of LCs with CP and the TRPV1 agonist rutaecarpine (Rut) increased CGRP secretion, reaching concentrations close to its IC50 for inhibition of HIV-1 trans-infection. Accordingly, CP significantly inhibited HIV-1 trans-infection, which was abrogated by antagonists of both TRPV1 and the CGRP receptor. Finally, pre treatment of inner foreskin tissue explants with CP markedly increased CGRP secretion, and upon subsequent polarized exposure to HIV-1, inhibited increase in LC-T-cell conjugate formation and T-cell infection. Together, our results reveal that alike nociceptors, LCs express functional TRPV1, whose activation induces CGRP secretion that inhibits mucosal HIV-1 transmission. Our studies could permit re-positioning of formulations containing TRPV1 agonists, already approved for pain relief, as novel topical microbicides against HIV-1.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Capsaicin activates TRPV1 in human Langerhans cells and inhibits mucosal HIV-1 transmission via secreted CGRP

Cohen

Zhu

Auffray

et al. 2021

Preprint

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“…Thus, the transmission of the painful stimulus from the peripheral nerve endings is reduced or completely eliminated. Capsaicin appears to have the potential to be the choice of neuropathic pain management [58].…”

Section: Topical Capsaicinmentioning

confidence: 99%

Diyabetik Nöropatiye Genel Yaklaşım

Uzuner

Ketenci²,

Salbaş

2020

Acta Medica Alanya

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ÖZ Diyabetik nöropati (DN), diabetes mellitusun en yaygın komplikasyonudur. Mikro ve makrovasküler hasara neden olur ve çoğu hekim tanıyı kolaylıkla gözden kaçırabilir. Genel olarak; DN tanısı, spesifik olmayan bulgularla başladığı, yavaş ilerleme gösterdiği ve birçok hastalığa ait şikayetlerle karışabileceği için diyabet tedavisi ile uğraşan hekimler tarafından ihmal edilebilir. 2030 yılında dünyada 578 milyon kişinin DM tanısı alacağı tahmin edilmektedir. Kronik hiperglisemi, mikrovasküler yetmezlik, oksidatif ve nitrozatif stres, bozulmuş nörotropizm ve otoimmünite sinir harabiyetine neden olan faktörlerden bazılarıdır. Karıncalanma, yanma, elektrik çarpması benzeri hisler, uyuşma, zonklama, bası, deriye iğne batması gibi parestezik yakınmalar en sık görülen semptomlardır. Diyabetik nöropatide nöronal hasarı tamamen ortadan kaldıran patogenetik mekanizmaların tedavisi yoktur. Tedavinin amacı hastalığın ilerlemesini yavaşlatmak, ağrıyı kontrol altına almak, komplikasyonları önlemek, oluşan komplikasyonların hızlı ve yeterli tedavisi ve hastanın fonksiyonel kapasitesini korumaktır. Bu derlemede, diyabetik nöropati, tanı ve tedaviye genel yaklaşımı kapsamlı bir şekilde ele almayı amaçladık.

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“…In addition to being the main component of chile peppers, capsaicin is reported to possess chemopreventive, antioxidant, anti-bacterial, anti-inflammatory and hypolipidemic effects. [12][13][14][15][16][17] Consequently, capsaicin finds use in a range of pharmaceuticals, drug delivery and medical applications such as inclusion in topical creams, liquids and patch preparations for chronic pain syndromes, dietary supplements to tackle obesity and defensive sprays. [18][19][20][21][22][23] As such, there is an analytical interest to measure capsaicinoids in a wide range of samples.…”

Section: Introduction: the Chile Peppermentioning

confidence: 99%

Electroanalytical overview: the pungency of chile and chilli products determined via the sensing of capsaicinoids

Crapnell

Banks

2021

Analyst

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Novel Agents in Neuropathic Pain, the Role of Capsaicin: Pharmacology, Efficacy, Side Effects, Different Preparations

Cited by 29 publications

References 54 publications

Capsaicin activates TRPV1 in human Langerhans cells and inhibits mucosal HIV-1 transmission via secreted CGRP

Capsaicin activates TRPV1 in human Langerhans cells and inhibits mucosal HIV-1 transmission via secreted CGRP

Diyabetik Nöropatiye Genel Yaklaşım

Electroanalytical overview: the pungency of chile and chilli products determined via the sensing of capsaicinoids

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