Novel Aerosol Delivery Devices

Singh, Supriya; Kanbar-Agha, Faisal; Sharafkhaneh, Amir

doi:10.1055/s-0035-1555612

Cited by 9 publications

(3 citation statements)

References 29 publications

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“…A number of high-tech add-on devices for MDI, DPI, and nebulizer products have been commercialized for MDI products (MD Turbo developed by Respirics, Propeller developed by Propeller Health, Smartinhaler developed by Adherium Ltd.). ( 126 ) Benefits to the patients of some of these products include providing reminders to take a dose or order a new inhaler, providing breath actuation, training the patient on the appropriate inhalation maneuver, and recording the time and location of each dose to evaluate adherence to the prescribed dosing regimen.…”

Section: Looking To the Futurementioning

confidence: 99%

The History of Therapeutic Aerosols: A Chronological Review

Stein

Thiel²

2017

Journal of Aerosol Medicine and Pulmonary Drug Delivery

229

134

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In 1956, Riker Laboratories, Inc., (now 3 M Drug Delivery Systems) introduced the first pressurized metered dose inhaler (MDI). In many respects, the introduction of the MDI marked the beginning of the modern pharmaceutical aerosol industry. The MDI was the first truly portable and convenient inhaler that effectively delivered drug to the lung and quickly gained widespread acceptance. Since 1956, the pharmaceutical aerosol industry has experienced dramatic growth. The signing of the Montreal Protocol in 1987 led to a surge in innovation that resulted in the diversification of inhaler technologies with significantly enhanced delivery efficiency, including modern MDIs, dry powder inhalers, and nebulizer systems. The innovative inhalers and drugs discovered by the pharmaceutical aerosol industry, particularly since 1956, have improved the quality of life of literally hundreds of millions of people. Yet, the delivery of therapeutic aerosols has a surprisingly rich history dating back more than 3500 years to ancient Egypt. The delivery of atropine and related compounds has been a crucial inhalation therapy throughout this period and the delivery of associated structural analogs remains an important therapy today. Over the centuries, discoveries from many cultures have advanced the delivery of therapeutic aerosols. For thousands of years, therapeutic aerosols were prepared by the patient or a physician with direct oversight of the patient using custom-made delivery systems. However, starting with the Industrial Revolution, advancements in manufacturing resulted in the bulk production of therapeutic aerosol delivery systems produced by people completely disconnected from contact with the patient. This trend continued and accelerated in the 20th century with the mass commercialization of modern pharmaceutical inhaler products. In this article, we will provide a summary of therapeutic aerosol delivery from ancient times to the present along with a look to the future. We hope that you will find this chronological summary intriguing and informative.

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Section: Looking To the Futurementioning

confidence: 99%

The History of Therapeutic Aerosols: A Chronological Review

Stein

Thiel²

2017

Journal of Aerosol Medicine and Pulmonary Drug Delivery

229

134

View full text Add to dashboard Cite

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“…Smart nebulizers have recently become available for individualized controlled inhalation, which allows a bolus aerosol inhalation technique adjusted to the patient's breathing pattern or lung function. 97,98 These systems combine nebulizer technology, flow and/or pressure sensors, and a microprocessor.…”

Section: Smart Nebulizersmentioning

confidence: 99%

“…When used with a mesh nebulizer, this system deposits ϳ 70% of the nominal nebulizer fill to the lungs. 97,98…”

Section: Smart Nebulizersmentioning

confidence: 99%

Aerosol Delivery Devices for Obstructive Lung Diseases

Pleasants

Hess

2018

Respir Care

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Drug delivery by inhalation is the principal strategy to treat obstructive lung diseases, which affect about 15% of the population in the United States. Aerosol delivery devices have evolved over more than 60 years from the basic pressurized metered-dose inhaler and nebulizer to numerous types of inhalers and devices, including valved holder chambers, dry powder inhalers, soft mist inhalers, as well as smart inhalers and nebulizers. Although these devices improve a patient's ability to self-administer medication, many problems with optimal delivery still exist. Appropriate selection and repeated patient education can help lessen the problems with these devices. Aerosol science is evolving, with methods of measurement that include radio-scintigraphy and magnetic resonance imaging, to provide a better understanding of aerosol delivery and effects. Understanding the science and clinical application of aerosol drug delivery can substantially aid clinicians in optimizing these therapies for their patients.

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Precision Ocular Drug Delivery Via Aerosol Ring Vortices

Herpin

2017

Pharm Res

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Novel Aerosol Delivery Devices

Cited by 9 publications

References 29 publications

The History of Therapeutic Aerosols: A Chronological Review

The History of Therapeutic Aerosols: A Chronological Review

Aerosol Delivery Devices for Obstructive Lung Diseases

Precision Ocular Drug Delivery Via Aerosol Ring Vortices

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