Novel aerosol assisted plasma deposition of PEG containing coatings for non-fouling application

Treglia, Annalisa; Palumbo, Fabio; Gristina, Roberto; Calvano, Cosima Damiana; Cataldi, Tommaso R. I.; Fracassi, Francesco; Favia, Pietro

doi:10.1016/j.apsusc.2020.146698

Cited by 15 publications

(7 citation statements)

References 28 publications

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“…A similar APPLD process was used by Nisol et al to deposit hydrogel-like coatings from tetraethyleneglycol dimethyl ether (tetraglyme) as liquid precursor injected in the remote discharge and treated for 10 min in an Ar plasma retaining a high PEG character of the deposit [64]. Furthermore, aerosol-assisted plasma deposition from PEG aqueous solutions can be supported by plasma polymerization of ethylene in a DBD working with He [65]. The latter formed a matrix entrapping the PEG domains on a polycarbonate substrate responsible for scarce endothelial cell adhesion and growth using a suitable concentration of PEG in the atomizer solution (10% w/v).…”

Section: Plasma-assisted Synthesis Of Hydrogelsmentioning

confidence: 99%

Plasma surface engineering for manmade soft materials: a review

Hegemann¹,

Gaiser²

2021

J. Phys. D: Appl. Phys.

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Manmade soft materials are important in a wide range of technological applications and play a key role in the development of future technologies, mainly at the interface of synthetic and biological components. They include gels and hydrogels, elastomers, structural and packaging materials, micro and nanoparticles as well as biological materials. Soft materials can be distinguished from liquids owing to their defined shape and from hard materials by the deformability of their shape. This review article provides an overview of recent progress on the plasma engineering and processing of softer materials, especially in the area of synthesis, surface modification, etching, and deposition. The article aims to demonstrate the extensive range of plasma surface engineering as used to form, modify, and coat soft materials focusing on material properties and potential applications. In general, the plasma provides highly energetic, non-equilibrium conditions at material surfaces requiring to adjust the conditions for plasma-surface interaction to account for the specifics of soft matter, which holds independent of the used plasma source. Plasma-induced crosslinking and polymerization of liquids is discussed to transform them into gel-like materials as well as to modify the surface region of viscous liquids. A major field covers the plasma surface engineering of manmade soft materials with the help of gaseous reactive species yielding ablation, nanostructuring, functionalization, crosslinking, stiffening, and/or deposition to obtain demanded surface properties or adhesion to dissimilar materials. Finally, plasma engineering of rigid materials is considered to induce surface softening for the enhanced contact with tissues, to allow interaction in aqueous media, and to support bonding to soft matter. The potential and future perspectives of plasma engineering will be discussed in this review to contribute to a higher knowledge of plasma interaction with sensitive materials such as soft matter.

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Section: Plasma-assisted Synthesis Of Hydrogelsmentioning

confidence: 99%

Plasma surface engineering for manmade soft materials: a review

Hegemann¹,

Gaiser²

2021

J. Phys. D: Appl. Phys.

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“…The deposition of PEO-like coatings, in aerosol, assisted DBD, produces rough coatings in our experimental conditions, probably due to the contribution of aerosol droplets to the polymerization or deposition of the monomer vapors that can lead to the formation of aggregates. [35,36]. Stallard et al [37] deposited PEO-like coatings on Si wafer surface using TEGDME and diethylene glycol vinyl ether monomers in a non-equilibrium AP plasma jet and reported the formation of particulate in the process as a result of a high degree of polymerization.…”

Section: Discussionmentioning

confidence: 99%

How to Confer a Permanent Bio-Repelling and Bio-Adhesive Character to Biomedical Materials through Cold Plasmas

et al. 2020

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Plasma Enhanced–Chemical Vapor Deposition (PE-CVD) of polyethylene oxide-like (PEO)-like coatings represent a successful strategy to address cell-behavior on biomaterials. Indeed, one of the main drawbacks of organic and hydrophilic films, like PEO-like ones, often consists in their poor adhesion to the substrate, especially in biological fluids where the biomaterial is required to operate. In this paper, low pressure (LP) and aerosol-assisted atmospheric pressure (aerosol-assisted AP) PE-CVD of PEO-like coatings is compared. The stability of the two different classes of coatings was investigated, both in water and in the cell culture media, during cell culture experiments. The obtained results show that, when deposited at atmospheric pressure (AP), the adhesion of the PEO-like coatings to the substrate has to be granted by an intermediate gradient layer. This interlayer can match the properties of the substrate with that of the topmost coatings, and, in turn, can dramatically improve the coating’s stability in complex biological fluids, like the cell culture medium. An accurate modulation of the experimental conditions, both at LP and AP, allowed control of the film chemical structure and surface properties, to permanently promote or discourage the cellular adhesion on the surfaces of biomaterials.

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“…The fabricated films could not only efficiently immobilize biomolecules (demonstrated by immobilization of metalloproteinase-7 (MMP-7) enzyme) but also prevent non-specific adsorption. PEG-containing coatings with cell repulsive properties were also deposited by aerosol-assisted plasma depositions through dielectric barrier discharges, a novel method developed by Treglia et al [107].…”

Section: Pecvdmentioning

confidence: 99%

Applications of soft biomaterials based on organic and hybrid thin films deposited from the vapor phase

Marcelja,

Demelius,

Ali

et al. 2023

J. Phys. Mater.

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Soft biomaterials are a crucial component in several application fields. They are used, for example, in biomedical implants, biosensors, drug delivery systems as well as in tissue engineering. In parallel to extensive ongoing efforts to synthesize new materials, the development of means to tailor the materials’ surface properties and thus their interaction with the environment is an important field of research. This has led to the emergence of several surface modification techniques that enable the exploitation of the modified materials in a broader range of technologies. In particular, the use of functional thin films can enable a plethora of biomedical applications, that benefit from the bulk properties of the substrate (e.g., flexibility, lightweight, structural strength) combined to the surface properties of the thin film (e.g, enhancing/prevention cell proliferation, controlled drug release). In addition, for some biomedical applications, the thin films can be the main functional components, e.g. in biosensors. The present review focuses on recent developments in the applications of soft biomaterials based on thin films deposited from the vapor phase. In the field of soft biomaterials, the possibility of depositing from the vapor phase - without the need for any solvents - offers the unprecedent benefit that no toxic leachables are included in the biomaterial. Further, due to the complete lack of solvents, and chemicals overall being used in small quantities only, depositing thin films from the vapor phase can be a more sustainable choice than other techniques that are commonly used.

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Novel aerosol assisted plasma deposition of PEG containing coatings for non-fouling application

Cited by 15 publications

References 28 publications

Plasma surface engineering for manmade soft materials: a review

Plasma surface engineering for manmade soft materials: a review

How to Confer a Permanent Bio-Repelling and Bio-Adhesive Character to Biomedical Materials through Cold Plasmas

Applications of soft biomaterials based on organic and hybrid thin films deposited from the vapor phase

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