Novel advances in biotransformation and bioactivation research – 2020 year in review

Abstract

This annual review is the sixth of its kind since 2016 (see references). Our objective is to explore and share articles which we deem influential and significant in the field of biotransformation and bioactivation. These fields are constantly evolving with new molecular structures and discoveries of corresponding pathways for metabolism that impact relevant drug development with respect to efficacy and safety. Based on the selected articles, we created three sections: (1) drug design, (2) metabolites and drug metabolizing enzymes, and (3) bioactivation and safety (Table 1). Unlike in years past, more biotransformation experts have joined and contributed to this effort while striving to maintain a balance of authors from academic and industry settings.Beyond biotransformation: Since the last review, significant events occurred that made 2020 a unique year; from environmental disasters (the COVID-19 pandemic and catastrophic wildfires) to cultural reactions about basic human rights (the Black Lives Matter movement and stop Asian hate movement). These events highlighted that we all have an important role to play in contributing to stronger diverse and inclusive communities. With all the privileges given to us, we need to give back in any way we can. As Dr. Martin Luther King, Jr. said, "The time is always right to do what is right."We would be pleased to hear your opinions, and we extend an invitation to anyone who would like to contribute to a future edition of this review.