Novel adipokines WISP1 and betatrophin in PCOS: relationship to AMH levels, atherogenic and metabolic profile

Ersoy, Gülçı̇n Şahin; Ensarı, Tuğba Altun; Vatansever, Doğan; Emirdar, Volkan; Çevik, Özge

doi:10.1080/09513590.2016.1223286

Cited by 27 publications

(19 citation statements)

References 29 publications

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“…Importantly, with the increase in circulating betatrophin concentration, adipose IR also increased significantly. ese results are consistent with most previous studies, which reported increased serum betatrophin levels in IR individuals or women with PCOS [31][32][33][34]. In a previous study, Adamska et al reported that betatrophin was closely related to IR and islet β-cell secretion.…”

Section: Discussionsupporting

confidence: 92%

Adipose Insulin Resistance and Circulating Betatrophin Levels in Women with PCOS

Wenjin²,

Yang³

et al. 2020

BioMed Research International

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The role of IR and metabolic disorders has become a crucial topic of study in the pathogenesis of PCOS. Adipose tissue is an important target organ of insulin, and adipose IR plays an important role in the occurrence and development of PCOS. This study seeks to investigate the role of adipose IR in the development of PCOS and to examine its relationship with circulating betatrophin levels in women with PCOS. A cross-sectional analysis of a cohort of women with PCOS and healthy women was performed in this study. Serum betatrophin concentrations were measured by ELISA. Adipose IR was calculated using the product of fasting insulin and FFA concentrations, and the relationship between adipose IR, circulating betatrophin, and other parameters was analyzed. Adipose IR in women with PCOS was significantly higher than that in controls. We found that women with PCOS who have adipose IR (adipose IR ≥ 55) have a higher BMI and higher blood glucose, insulin, PRL, FFA, TG, HOMA-IR, AUCglucose, AUCinsulin, VAIfemale, and BAI levels than PCOS-afflicted women without adipose IR, while M-values, and SHBG and LH levels were lower. In women with PCOS, serum betatrophin levels were significantly increased compared with controls. Adipose IR negatively correlated with M values and positively with circulating betatrophin levels in the study population. After metformin treatment, circulating betatrophin levels and adipose IR in women with PCOS were significantly decreased compared with pretreatment. Adipose IR is associated with betatrophin levels in women with PCOS. The combination of adipose IR and circulating betatrophin measurements may be significant for screening patients with PCOS.

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Section: Discussionsupporting

confidence: 92%

Adipose Insulin Resistance and Circulating Betatrophin Levels in Women with PCOS

Wenjin²,

Yang³

et al. 2020

BioMed Research International

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“…A novel circulating hormone, betatrophin, secreted both by the adipose tissue and liver, has been found to be elevated in PCOS and strongly associated with androgens, BMI and IR (105). Moreover, betatrophin was shown to be an independent predictor of fibrosis in patients with NAFLD (106).…”

Section: Molecular Basis Including Endocrine Disruptorsmentioning

confidence: 98%

MANAGEMENT OF ENDOCRINE DISEASE: Polycystic ovary syndrome and nonalcoholic fatty liver disease

Macut

Božić-Antić

Bjekić-Macut

et al. 2017

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) is a frequent endocrine disease in women, with a number of metabolic and reproductive consequences. Obesity, insulin resistance (IR) and type 2 diabetes are prominent metabolic characteristics of PCOS and common factors affecting liver function and generating nonalcoholic fatty liver disease (NAFLD). Multiple genes involved in the synthesis of androgens, cytokines and IR, as well as acquired factors, such as endocrine disruptors, could associate the etiopathogenesis of PCOS and NAFLD. Besides the high prevalence of PCOS in general population, NAFLD was shown to be a frequent condition in transition periods, such as adolescence and menopause. Although liver biopsy is considered to be the gold standard for diagnosing liver damage, its routine use in such a prevalent condition as PCOS can be related to a higher rate of complications. Therefore, it is necessary to be able to diagnose NAFLD using simple and reliable surrogate markers. Recently, fatty liver index and NAFLD fatty liver score analyzed in large cohorts of PCOS women have been shown as accurate markers of liver damage in this metabolically vulnerable population. Lifestyle changes are still the mainstay of the management of NAFLD in PCOS, although prospective randomized controlled clinical studies remain a priority in the field. With regard to medications, metformin may be the drug of choice for treating PCOS patients with NAFLD when pharmacologic therapy is considered. Liraglutide use in obese PCOS has shown favorable effects on the predictors of liver fibrosis. In this review, we aim to summarize the influence of the common risk factors and to discuss the diagnostic approaches and management options for NAFLD in patients with PCOS.

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“…Of these studies included, 12 studies recruited patients with T2DM [8, 9, 12-14, 20, 22-27], of which one recruited patients undergoing CD [13], and 5 enrolled GDM [15,16,[28][29][30], 3 enrolled PCOS [17,21,31], 2 enrolled adult with different body weight (BW) [10,32], one enrolled Mets [18] and 2 enrolled NAFLD [19,33]. Twenty-two studies in all included studies were cross-sectional studies, 3 were case control studies.…”

Section: Description Of Included Studiesmentioning

confidence: 99%

The Correlation Between Circulating Betatrophin and Insulin Resistance in General Population: A Meta-Analysis

Lin

Zhou

et al. 2017

Horm Metab Res

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Many inconsistent findings are reported on the correlation between circulating betatrophin and insulin resistance in the different population. The aim of this analysis was to explore the correlation between the level of betatrophin and insulin resistance in the general population. The databases of PubMed, EMBASE, and the Cochrane Library (inception to October 26, 2016) were searched without language restrictions for publications that reported studies on associations between betatrophin and insulin resistance in adults. Subgroup analyses were performed to investigate potential sources of heterogeneity. The pooled effect size was calculated using a random-effects model. Twenty-five studies were included in this meta-analysis. Meta-analysis showed that betatrophin was positively and significantly correlated with insulin resistance (r=0.16, 95% CI: 0.08-0.25). When all participants were divided into DM, GDM, and Non-DM groups, this association was also significant in T2DM, GDM, and Non-DM participants (T2DM: r=0.09, 95% CI: 0.01-0.17; I =45.1%; GDM: r=0.39, 95% CI: 0.24-0.55; I=0.0%; non-DM: r=0.15, 95% CI: 0.04-0.26; I =89.3%), and it was obvious that heterogeneity existed in Non-DM group (I=89.3%, p<0.001). Subgroup analysis revealed that gender, serum sample and ELISA kits for full-length betatrophin had significant influence on the association between betatrophin and insulin resistance. In conclusion, the level of circulating betatrophin is positively associated with insulin resistance in the general population, especially in T2DM and GDM patients. Gender, serum sample, and ELISA kits for full-length betatrophin may affect this association. More large-scale studies are needed to determine whether improving insulin resistance concomitantly declines betatrophin levels in different diseases.

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Novel adipokines WISP1 and betatrophin in PCOS: relationship to AMH levels, atherogenic and metabolic profile

Abstract: WISP1 and betatrophin may play a key role on the pathogenesis of PCOS.

Cited by 27 publications

References 29 publications

Adipose Insulin Resistance and Circulating Betatrophin Levels in Women with PCOS

Adipose Insulin Resistance and Circulating Betatrophin Levels in Women with PCOS

MANAGEMENT OF ENDOCRINE DISEASE: Polycystic ovary syndrome and nonalcoholic fatty liver disease

The Correlation Between Circulating Betatrophin and Insulin Resistance in General Population: A Meta-Analysis

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